Figure - available from: Research and Reports in Urology
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The diffuse brown color on immunohistochemistry staining indicates positive compatibility of antibody against targeted antigen. (A) 10x Inhibin (+); (B) 40x Calretinin (+); (C) 20 Vimentin (+); (D) 40 CD99 (+).
Source publication
Omar Halalsheh,1 Alia Al-Mohtaseb,2 Anas Ibrahim Al-Karasneh,3 Mustafa Mokhalad Al-Janabi,3 Amer Hussein Hallak41Department of Surgery and Urology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan; 2Department of Pathology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan; 3Urology, King...
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Juvenile granulosa cell tumor (JGCT), which is one of the sex cord-stromal tumors of the ovary, is a rare malignancy of childhood. Juvenile type is a rare form that accounts for 5% of granulosa cell tumors. Isosexual precocious puberty is the most common presentation in prepubertal girls with juvenile granulosa cell tumors. Less frequently, they pr...
Granulosa cell tumors of the ovary are sex cord stromal tumors. Sex cord stromal tumors make up 8% of ovarian tumors. Ninety percent of sex cord stromal tumors of the ovary are granulosa cell tumors. There are two types of granulosa cell tumors: juvenile and an adult type (Jamieson and Fuller. Molecular pathogenesis of granulosa cell tumors of the...
Background: Ovarian sex-cord stromal tumors (SCST) are rare group of tumors constituting approximately 5 to 10 % of all ovarian neoplasms, and they are infrequent in the paediatric age group. They exhibit a wide range of differentiation, and their varied clinical presentations and pathological ndings necessitate a systematic study of these tumours...
Patient: Female, 46-year-old
Final Diagnosis: Microcystic stromal tumor of the ovary
Symptoms: Abdominal pain • vaginal bleeding
Medication: —
Clinical Procedure: —
Specialty: Pathology
Objective
Rare disease
Background
Microcystic stromal tumor (MCST) of the ovary is a rare entity with distinct pathological and molecular features. However, a lac...
Rationale:
Granulosa cell tumors (GCTs) are rare, hormonally active sex cord-stromal tumors that generally present as solid unilateral ovarian lesions. It's quite uncommon that they present as pure bilateral ovarian cysts. Histopathology remains the gold standard for making a diagnosis of GCTs. However, as the differential diagnosis is difficult,...
Citations
... The juvenile type is usually benign, whereas the adult type has a clinical behavior that is difficult to predict. 2 Less than 100 cases of adult-type granulosa cell tumors have been reported to date of which the youngest was 12 years old of age and none of them had over 30 years history duration with reported duration varying from 2 weeks to 10 years. [3][4][5] ...
... The juvenile type mostly occurs in the first 6 months of life and has a benign course, whereas the adult type even though mostly benign, 10% have malignant potential. 5,6 Adult-type granulosa cell tumor usually manifests as a painless scrotal swelling; the minority of cases may present with gynecomastia. 2,7 Reported cases found in the literature presented between 2 weeks to 10 years of onset swelling. ...
... Our patient is the first report with over 30 years history duration. [3][4][5] The youngest ever reported case of the adult type was 12 years old, whereas the oldest subject was 87 years old. 4 The present case was 49 years old, and he reported to have had the swelling since he was 12 years old and it was never painful. None of the precedent case reports had such long history duration. ...
Adult type granulosa cell tumours are extremely rare. Albeit mostly benign, 10% have malignant potential associated with unfavorable pathological features. The present case with the longest history duration, shows that size alone may not necessarily be unfavorable prognosticator when not associated with other factors.
