Figure 1 - uploaded by Caitriona Collins
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1 The centromere and CENP-A nucleosomes. The centromere composed of CENP-A (green) containing nucleosomes versus canonical histone H3 (blue) containing nucleosomes of non-centromeric chromatin.
Source publication
Recent studies in plants and Drosophila suggest that CENP-A, the
centromeric histone H3 variant and epigenetic marker of centromere
localisation may have additional roles during meiosis.
By immunoprecipitation and mass spectrometry we have identified
components of the mitochondrial ATP synthase F1 complex as potential
meiotic CENP-A interactors. P...
Context in source publication
Context 1
... has been shown previously, in WT (y+ry+) flies an average of 6.41 centromeres was observed per nucleus at late prophase I ( figure 5.11). GFP-CENP-A-Δ118 was also found to induce a dominant negative effect on centromeric cohesion maintenance however in the case of this N-terminally truncated GFP-CENP-A the observed defect was significantly (p<0.01) more severe than that observed for the control gfp-cenp-a-fl. homozygotes and GFP-CENP-A-Δ118 homozygotes and heterozygotes. The average number of centromeric foci per nucleus is indicated, data pooled from 3 independent RNAi experiments, n=100 nuclei. ***p<0.001, **p<0.01, *p<0.05 and ns is a ...
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