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The apoptosis signal transduction pathway (A-E) Semi-quantification of g-H2AX and percentage of (b) Bcl-2-positive, (c) Caspase-3-positive, (d) Bax -positive and (e) Ki-67-positive cells in histological sections of different treatment groups. (F) TUNEL expression in tumor sections. (G) Representative images of H&E staining, immunofluorescence images of g-H2AX and TUNEL, immuno-histochemical staining images of Ki-67, Bcl-2, caspase-3, and Bax on the tumor slices. Statistical significance was calculated via one-way ANOVA with Tukey's post hoc test. Data are given as means G SD. *p % 0.05 and ***p % 0.001.
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Covalent organic frameworks (COFs) have garnered enormous attention in anti-cancer therapy recently. However, the intrinsic drawbacks such as poor biocompatibility and low target-specificity greatly restrain the full clinical implementation of COF. Herein, we report a biomimetic multifunctional COF nanozyme, which consists of AIEgen-based COF (TPE-...
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... schematically depicted in Figure 2A, the TPE-s COF-Au@ Cisplatin carrier was co-cultured with HepG2 cells that were cryo-shocked to afford cell membrane (M) fusion TPE-s COF nanoenzyme (termed M@TPE-s COF-Au@Cisplatin). The average hydrodynamic diameters of TPE-s COF-Au and M@TPE-s COFAu@Cisplatin are $100 nm and $220 nm, respectively ( Figures S5 and S6). In addition, the Zeta potential of TPE-s COF, TPE-s COF-Au@Cisplatin, and M@TPE-s COF-Au@ Cisplatin gradually decreased, indicating the increased negative charges ( Figure 2B). ...
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Although low‐cost nanozymes with excellent stability have demonstrated the potential to be highly beneficial for nanocatalytic therapy (NCT), their unsatisfactory catalytic activity accompanied by intricate tumor microenvironment (TME) significantly hinders the therapeutic effect of NCT. Herein, for the first time, a heterojunction (HJ)‐fabricated...
Citations
... Then, COF nanozymes with simulated nitroreductase activity and peroxide-mimetic enzyme activity were pre pared by in situ loading AuNPs in COF through hydrogen bonding or π-π bonding. Zhou et al. [30] also used the condensation reaction of aldehydes and amines to prepare imine linked tetragonal COF nanozymes (Tph-BDP) through the combination of [C2 + C2] and the solvothermal synthesis method. Then, AuNPs were loaded in situ through strong Au SH interaction to prepare COF nanozymes for the treatment of liver cancer ( Figure 3C) From the above research results, it can be concluded that the design of COF nanozymes is traceable. ...
... Then, COF nanozymes with simulated nitroreductase activity and peroxide-mimetic enzyme activity were prepared by in situ loading AuNPs in COF through hydrogen bonding or π-π bonding. Zhou et al. [30] also used the condensation reaction of aldehydes and amines to prepare imine-linked tetragonal COF nanozymes (Tph-BDP) through the combination of [C2 + C2] and the solvothermal synthesis method. Then, AuNPs were loaded in situ through strong Au-SH interaction to prepare COF nanozymes for the treatment of liver cancer ( Figure 3C). ...
... Under visible light irradiation, Tph-BDP can rapidly catalyze the oxidation of TMB and exhibit excellent simulated oxidase activity ( Figure 4). [26], Fe-COF-H3 (B) [27], and COF-Au@Cisplatin [30] (C). ...
Covalent organic frameworks (COFs) are porous crystals that have high designability and great potential in designing, encapsulating, and immobilizing nanozymes. COF nanozymes have also attracted extensive attention in analyte sensing and detection because of their abundant active sites, high enzyme-carrying capacity, and significantly improved stability. In this paper, we classify COF nanozymes into three types and review their characteristics and advantages. Then, the synthesis methods of these COF nanozymes are introduced, and their performances are compared in a list. Finally, the applications of COF nanozymes in environmental analysis, food analysis, medicine analysis, disease diagnosis, and treatment are reviewed. Furthermore, we also discuss the application prospects of COF nanozymes and the challenges they face.
Nanomedicines are extensively used in cancer therapy. Covalent organic frameworks (COFs) are crystalline organic porous materials with several benefits for cancer therapy, including porosity, design flexibility, functionalizability, and biocompatibility. This review examines the use of COFs in cancer therapy from the perspective of reticular chemistry and function‐oriented materials design. First, the modification sites and functionalization methods of COFs are discussed, followed by their potential as multifunctional nanoplatforms for tumor targeting, imaging, and therapy by integrating functional components. Finally, some challenges in the clinical translation of COFs are presented with the hope of promoting the development of COF‐based anticancer nanomedicines and bringing COFs closer to clinical trials.
Nanomedicines are extensively used in cancer therapy. Covalent organic frameworks (COFs) are crystalline organic porous materials with several benefits for cancer therapy, including porosity, design flexibility, functionalizability, and biocompatibility. This review examines the use of COFs in cancer therapy from the perspective of reticular chemistry and function‐oriented materials design. First, the modification sites and functionalization methods of COFs are discussed, followed by their potential as multifunctional nanoplatforms for tumor targeting, imaging, and therapy by integrating functional components. Finally, some challenges in the clinical translation of COFs are presented with the hope of promoting the development of COF‐based anticancer nanomedicines and bringing COFs closer to clinical trials.
