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The anticancer properties of Fomitopsis pinicola. Effects of different mushroom derivatives and their mechanisms of actions on various models are depicted. Mouse and cell icons indicate results obtained on animal and cell models, respectively. ROSreactive oxygen species, MMP↓-downregulation of matrix metalloproteinases.
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Medicinal mushrooms have been used throughout the history of mankind for treatment of various diseases including cancer. Nowadays they have been intensively studied in order to reveal the chemical nature and mechanisms of action of their biomedical capacity. Targeted treatment of cancer, non-harmful for healthy tissues, has become a desired goal in...
Contexts in source publication
Context 1
... pinicola, class Agaricomycetes, order Polyporales, family Fomitopsidaceae (common name Red Belted Conk) (Figure 1), is a brown rot fungus, a member of Basidiomycota. It is saprotrophic on the dead wood of coniferous and broad-leaved trees, which are common throughout the temperate Northern Hemisphere. ...
Context 2
... pinicola, class Agaricomycetes, order Polyporales, family Fomitopsidaceae (common name Red Belted Conk) (Figure 1), is a brown rot fungus, a member of Basidiomycota. It is saprotrophic on the dead wood of coniferous and broad-leaved trees, which are common throughout the temperate Northern Hemisphere. ...
Context 3
... pinicola, class Agaricomycetes, order Polyporales, family Fomitopsidaceae (common name Red Belted Conk) (Figure 1), is a brown rot fungus, a member of Basidiomycota. It is saprotrophic on the dead wood of coniferous and broad-leaved trees, which are common throughout the temperate Northern Hemisphere. ...
Citations
... Other studies found that the T. versicolor also contains protein-bound polysaccharides like polysaccharide krestin (PSK) and polysaccharide peptides (PSP) [28]. These polysaccharide-peptides play a role in promoting the immune response by activating and inhibiting specific immune cells and also by reducing inflammation. ...
This comprehensive literature review delves into the multifaceted attributes of Trametes versicolor, commonly known as turkey tail mushroom. The turkey tail mushroom stands as a noteworthy source of diverse bioactive compounds with potent health benefits. This review offers a contemporary synthesis of its phytochemical constituents and their multifaceted impacts on human health. The mushroom's intricate composition, encompassing polysaccharides, phenols, and triterpenes, underpins its remarkable therapeutic potential. Focusing on key attributes such as anti-cancer, anti-microbial, and immunomodulatory activities, this review delves into the intricate mechanisms by which the turkey tail mushroom exerts its effects. In addition, the exploration extends to the enzymatic constituents inherent in the mushroom and their industrial significance. Mechanisms of action for both phytochemicals and enzymes are studied, providing a well-rounded understanding of their roles in conferring therapeutic and industrial benefits. This synthesis of research aims to provide an up-to-date perspective on turkey tail mushrooms' versatile applications. By intertwining the exploration of health benefits and enzymatic constituents, this review offers insights into the potential of harnessing this natural resource for innovative therapeutic strategies and industrial applications. Overall, it contributes to the advancement of knowledge and utilisation of turkey tail mushrooms' diverse properties for human health and industrial progress.
... Multiple studies have extensively examined the diverse functions of medicinal mushrooms, emphasizing their significant potential for application in the medical field. However, a specific focus has been placed on investigating their antitumor and immunomodulatory characteristics, as cancer continues to pose a formidable obstacle [24]. The multifaceted anticancer properties of mushrooms mostly stem from the diverse groupings of distinctive chemicals that engage with malignant tissues and cells via a broad spectrum of biological mechanisms, yielding therapeutic outcomes [25]. ...
Mushrooms, due to their many medical, preventive, and nutraceutical purposes, as well as their reputation as a folk remedy, have long been an integral part of traditional cuisines. The therapeutic advantages of mushrooms may be attributed to their bioactive components, including polysaccharides (both low and high molecular weight), terpenoids, phenolic compounds, fatty acids, lectins, and glucans. The bioactive components have been discovered to possess various health advantages, including antibacterial, antifungal, anticancer, radical scavenging, cardiovascular, anti-hypercholesterolemia, and anti-diabetic effects. These effects have gained worldwide attention and stimulated interest in further investigating their potential applications. Functional foods have the dual purpose of serving as both nourishment and medication. They may assist in the management and prevention of health disorders that are not functioning optimally, as well as mitigate some adverse effects of life-threatening diseases. Further evaluation is necessary to fully understand the mechanisms via which mushrooms operate and improve their therapeutic properties. This review delves into the possible medicinal potential of mushrooms and the advantages they may provide to human health.
... The mushrooms that showed activity against cervical cancer are Pleurotus, Agaricus, 34 Ganoderma, 35 Cordyceps, 36 Schizophyllum, 37 Inonotus. 38 ...
The evolving landscape of personalized medicine necessitates a shift from traditional therapeutic interventions towards precision‐driven approaches. Embracing this paradigm, our research probes the therapeutic efficacy of the aqueous crude extract (ACE) of Calocybe indica in cervical cancer treatment, merging botanical insights with advanced molecular research. We observed that ACE exerts significant influences on nuclear morphology and cell cycle modulation, further inducing early apoptosis and showcasing prebiotic attributes. Characterization of ACE have identified several phytochemicals including significant presence of octadeconoic acid. Simultaneously, utilizing advanced Molecular Dynamics (MD) simulations, we deciphered the intricate molecular interactions between Vascular Endothelial Growth Factor (VEGF) and Octadecanoic acid to establish C.indi ca's role as an anticancer agent. Our study delineates Octadecanoic acid's potential as a robust binding partner for VEGF, with comprehensive analyses from RMSD and RMSF profiles highlighting the stability and adaptability of the protein–ligand interactions. Further in‐depth thermodynamic explorations via MM‐GBSA calculations reveal the binding landscape of the VEGF–Octadecanoic acid complex. Emerging therapeutic innovations, encompassing proteolysis‐targeting chimeras (PROTACs) and avant‐garde nanocarriers, are discussed in the context of their synergy with compounds like Calocybe indica P&C. This convergence underscores the profound therapeutic potential awaiting clinical exploration. This study offers a holistic perspective on the promising therapeutic avenues facilitated by C. indica against cervical cancer, intricately woven with advanced molecular interactions and the prospective integration of precision therapeutics in modern oncology.
... Throughout evolution, nature has produced a vast diversity of biologically active substances that possess enormous therapeutic potential in the treatment of various diseases, either directly as drugs or as lead compounds for drug development. These confirm their use in traditional medicine which have always been important clues pointing to potential new sources of compounds with therapeutic activity (Blagodatski et al. 2018;Lindequist et al. 2014). Though natural products have been used as medicine for centuries, only in the last century have researchers begun to diligently characterize their biological and chemical properties (Zeb & Lee 2021). ...
The use of medicinal plants as food and medicine has been a common practice in the world, especially in tropical African countries. One such plant in West Africa is Uvaria chamae, also known as Bush banana, renowned for its diverse ethnomedicinal applications and, more recently, for its pharmacological activities attributed to a rich array of phytochemical constituents. Various parts of the plant have been traditionally employed for the treatment of diverse health issues such as digestive disorders, fever, dysmenorrhea, cancer, wound healing, and many more. To unravel the bioactive compounds responsible for these medicinal properties, a comprehensive phytochemical analysis has been undertaken. Notable isolates include chamanetin, dichamanetin, uvaretin, and uvarinol from different parts of the plant. The pharmacological evaluation of these compounds has revealed significant anticancer and antimicrobial properties. Therefore, this review provides a thorough examination of the phytochemicals derived from Uvaria chamae, detailing their associated pharmacological activities both in vitro and in vivo. The review emphasizes the potential of Uvaria chamae as a valuable source of lead compounds for cancer chemotherapy and antimicrobial drug discovery.
... Soil heavy metals and metalloids including mercury (Hg), cadmium (Cd), lead (Pb) and arsenic (As) pose potential risks to human health via food chains. Mushroom is famous for its particular flavour and rich in valuable nutritious such as proteins, minerals and vitamins (Blagodatski et al., 2018). However, mushrooms can accumulate soil toxic heavy metals to high concentrations, thus their potential in threatening food safety and human health deserves great attention (Bernaś et al., 2006). ...
... It has many positive effects and has received great attention during the past ten years, especially for its importance in treating many pathological conditions [11,12]. It contains some active substances, including pyrone, alkaloids, terpenoids, steroids, and peptides, so it is considered as an effective antioxidant [13], anti-inflammatory [14], and antiviral [15] and it also has an effect for many types of cancer [16], antiviral properties [17], antifungal properties [18], anti-harmful bacteria (Staphylococcus aureus, Salmonella enteritidis, Vibrio parahaemolyticus and Escherichia coli [19] and hepatoprotective properties [10]. Adding it to the diets may work to enhance the productive and immune performance of agricultural animals, including poultry. ...
Research on the effects of supplementing broiler diets with Lion’s mane (Hericium erinaceus) and Reishi Mushroom (Ganoderma lucidum) was conducted in the field from March 22, 2022, to April 18, 2022, by the Department of Animal Production in the College of Agricultural Engineering Sciences at the University of Baghdad in Abu Ghraib. There were a total of 210 one-day-old Ross 308 broiler chicks employed in this study (10 birds per replicate), and they were fed a starter diet for the first 10 days, a growth diet for the next 11-24 days, and a final diet for the last 25-42 days. The birds were randomly assigned to one of seven treatments, with three replicates per treatment and ten birds in each replicate. The experimental procedures included:Treatment 1 (T1) is a diet with no extra ingredients. The second diet (T2) includes 1 g/kg of lion’s mane (Hericium erinaceus) fodder, the third diet (T3) includes 1.5 g/kg of lion’s mane (Hericium erinaceus), and the fourth diet (T4) includes 2 g/kg of lion’s mane (Hericium erinaceus), the fifth diet (T5) includes 1 g/kg of reishi mushroom (Ganoderma Treatments T4 (2 g/kg of Lion’s mane (Hericium erinaceus) and T6 (1.5 gm of Reishi Mushroom (Ganoderma lucidum)) were superior on the control treatment T1 in the sixth week, while in the fifth week, treatment T6 (1.5 g/kg of Reishi Mushroom) showed a significant increase in weekly average body weight over the control treatment T1. The ratio of weight gain to treatment time was found to be significantly higher for treatments T4 and T6 compared to the control treatment T1 (P<0.01). At 6 weeks of age, the feed consumption ratio increased significantly for treatments T5, T6, and T7 compared to the control treatment T1, and a high significant improvement (P<0.01) in the feed conversion ratio was observed, most notably for the birds in treatment T4, to which Lion’s mane (Hericium erinaceus) was added to their diets at a rate of 2 g / kg. There was a significant (P≤0.05) increase in the relative weight of the liver for birds of treatment T2 (1g/kg Lion’s mane (Hericium erinaceus) and T6 (1.5g/kg Reishi Mushroom (Ganoderma lucidum)) compared to the control treatment T1. The results of this investigation suggest that varying concentrations of Lion’s mane (Hericium erinaceus) and Reishi Mushroom (Ganoderma lucidum) may help boost grill performance.
... Decoctions and infusions can help to cope with sweating in fevers of various etiologies. Agarikon powder acts as a hemostatic and antimicrobial agent (Lindequist et al. 1990;Ren et al. 2012;Vazirian et al. 2016;Blagodatski et al. 2018;Elkhateeba et al. 2019; https:// lektrava.ru/encyclopedia/agarikus/). ...
... L. officinalis was used as a source of an antibacterial, antifungal, anti-inflammatory, antitumor, antiviral, and immunostimulant agents (Lindequist et al. 1990;Ren et al. 2012;Vazirian et al. 2016;Blagodatski et al. 2018;Elkhateeba et al. 2019). In addition, this fungus would be used to cure gastrointestinal problems, asthma or night sweats (Vitak et al. 2017). ...
Laricifomes officinalis (Vill.) Kotl. & Pouzar - FOMITOPSIDACEAE
Yusufjon Gafforov, Bożena Muszyńska, Katarzyna Sułkowska-Ziaja, Michal Tomšovský, Manzura Yarasheva, Lorenzo Pecoraro, Oksana Mykchaylova et Sylvie Rapior.
Laricifomes officinalis (Vill.) Kotl. & Pouzar - FOMITOPSIDACEAE. Pages 1237-1251. doi:10.1007/978-3-031-23031-8_116 ; hal-04373827v1
... Several active compounds in a single mushroom species have the ability to influence several cancer-related pathways in a synergistic manner (Blagodatski et al. 2018, Joseph et al. 2018). This has led to increased interest in the use of medicinal mushrooms in Western countries, especially after the publication of a significant number of pre-clinical studies which showed that they have anti-cancer and regenerative characteristics, little is known about their therapeutic utility (Jeitler et al. 2020). ...
... Cancer fungotherapy presents a promising scientific field and is focused on recognition of substances derived from mushrooms that exert antitumor activity (Blagodatski et al., 2018). In many studies, researchers investigated the cytotoxic effects of various mushroom extracts on cancer cells (Blagodatski et al., 2018;Klaus et al., 2013;Šeklić et al., 2016). ...
... Cancer fungotherapy presents a promising scientific field and is focused on recognition of substances derived from mushrooms that exert antitumor activity (Blagodatski et al., 2018). In many studies, researchers investigated the cytotoxic effects of various mushroom extracts on cancer cells (Blagodatski et al., 2018;Klaus et al., 2013;Šeklić et al., 2016). ...
Laetiporus sulphureus (Bull.) Murrill is a well-known edible mushroom consumed in nutrition as delicacy. It has been used in traditional medicine because of its beneficial effects on human wellness, such as antimicrobial, antioxidant, and anticancer potential. The present study determined the phenolic profile of Laetiporus sulphureus ethanolic extract (LSE) by high-performance liquid chromatographic method. Tolerance of two probiotic bacterial strains Lactiplantibacillus plantarum 229v, Bifidobacterium animalis subsp. lactis and probiotic yeast Saccharomyces boulardii on LSE was analyzed in terms of viability and biofilm formation. Effects of extract on colorectal (HCT-116) and cer-vical (HeLa) cancer cells viability was determined using MTT test in concentration range: 1-500 μg/mL after 24 and 72 h. Redox parameters (superoxide anion radicals, nitrites, and reduced glutathione) were evaluated using NBT, Griess, and GSH assays in the concentration range of 1-500 μg/mL after 24 and 72 h. Antimigratory activity was determined by wound healing method using selected concentrations of 10 and 50 μg/mL after 24 h. Untreated cells were considered as control. As control cell line, we used healthy fibroblasts (MRC-5). Our results demonstrated abundance of LSE in phenolics, with rosmarinic acid as the main component. LSE induced low tolerance of tested planktonic probiotic strains, with no affection on their ability to form biofilm. No significant cytotoxicity on tested cancer cells was observed, with prooxidative and antimigratory effects noticed. Extract exerted significant antimigratory activity on cancer cells without effect on planktonic and probiotic cultures in biofilm. These results indicate potential application of Laetiporus sulphureus ethanolic extract as natural protector of probiotics with prominent ability to suppress cancer cell motility. K E Y W O R D S antibiofilm activity, migration, mushroom, phenolic profile, probiotics 2 | JOVANOVIĆ et al.
... The interest in fungi as a raw material that can be used in medicine and in the production of natural pharmaceuticals is associated with their pro-health properties [1]. Edible mushrooms with medicinal properties are an abundant source of biologically active compounds, e.g., polyphenols, polysaccharides, terpenoids, steroids, cerebrosides, and proteins [2]. Given their pro-health properties, mushrooms are well-known elements of traditional diets and medicine in Asian countries. ...
The influence of the addition of 2.5, 5, 7.5, and 10.0% of dried Enoki and Maitake mushrooms on the content of bioactive compounds and some nutraceutical properties of pasta was determined in the study. The LC-MS/MS analysis of phenolic compounds revealed the highest amount of phenolic compounds in the Maitake-supplemented pasta. However, all the samples of the Enoki-enriched pasta exhibited a statistically significantly higher content of α-glucans than the control. Samples subjected to gastrointestinal digestion had significantly higher antioxidant and potential anti-inflammatory activities than ethanolic and buffer extracts (PBS). The ethanolic extracts from the Enoki- and Maitake-supplemented pasta had higher antioxidant activity (in some antiradical and reducing power assays) and higher lipoxygenase (E2.5 and E5 samples) inhibitory potential compared to the control sample. Additionally, some in vitro digested samples of pasta enriched with dried Enoki and Maitake mushrooms showed higher chelating power (E10, M7.5, and M10), reducing power (E5, E7.5, and M10), and lipoxygenase inhibition ability (E7.5, E10, and M10) than the control. In conclusion, the fortification of pasta with 7.5% and 10% of Enoki mushrooms and with 10% of Maitake mushrooms can be recommended.
