Figure - available from: Cancer Cell International
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The PAF-AH IB2 KD activated caspases and cell cycle arrest in the ovarian cancer cell. Knockdown PAF-AH 1B2 causes cell cycle arrest of cancer cells identified by BrdU-PI staining analysis (A). Representative histograms for cell cycle phase distribution in control and PAF-AH 1B2 KD cells are shown (B). Using ANNEXIN V (FITC, green) staining kit by fluorene microscope to evaluate the apoptosis effect induced by PAF-AH 1B2 KD and PAF, C-PAF (C and D). Data represent as the mean ± S.E.M (n = 10). Western blot detected the signaling molecules change pattern in the PAF-AH 1B2 KD cells that involved in the cell cycle related signaling pathway (E) and quantitively analysis (F). *P < 0.05; **P < 0.01, and ***P < 0.001 represented as compared with control cells expressing a scramble shRNA control, paired t test
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Background
Ovarian cancer is the leading cause of death from gynaecologic illnessed worldwide. Platelet-activating factor acetyl hydrolase IB2 (PAF-AH IB2) is an intracellular serine esterase that hydrolyzes platelet-activating factor, a G-protein-like trimer with two catalytic subunits and one regulatory subunit. The regulatory role of PAF-AH IB2...
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Citations
Background
Abnormal metabolism is the main hallmark of cancer, and cancer metabolism plays an important role in tumorigenesis, metastasis, and drug resistance. Therefore, studying the changes of tumor metabolic pathways is beneficial to find targets for the treatment of cancer diseases. The success of metabolism-targeted chemotherapy suggests that cancer metabolism research will provide potential new targets for the treatment of malignant tumors.
Purpose
The aim of this study was to systemically review recent research findings on targeted inhibitors of tumor metabolism. In addition, we summarized new insights into tumor metabolic reprogramming and discussed how to guide the exploration of new strategies for cancer-targeted therapy.
Conclusion
Cancer cells have shown various altered metabolic pathways, providing sufficient fuel for their survival. The combination of these pathways is considered to be a more useful method for screening multilateral pathways. Better understanding of the clinical research progress of small molecule inhibitors of potential targets of tumor metabolism will help to explore more effective cancer treatment strategies.
