Figure 1 - The JAK-STAT pathway in blood cell formation and immunity

Figure 1. The JAK-STAT signaling pathway in Drosophila melanogaster. (A) Activation of JAK-STAT signaling. Binding of either cytokine, unpaired (upd1, 2, and 3), to the type i cytokine receptor Domeless activates trans-phosphorylation of the JAK kinase Hopscotch (Hop) and Dome phosphorylation, creating a docking site for STAT (Stat92e). Hop-phosphorylated STAT forms dimers which translocate into the nucleus and activate target genes via binding to TTcN (3-4)GAA sites. The green box in Dome corresponds to the cytokine binding domain (cBM), the blue box to a conserved region between Lat/et and Dome (LDHR), the fibronectin iii (Fn iii) motifs are in red, the signal peptide in yellow and the intra-cytoplasmic region in gray. (B) Negative regulation of JAK-STAT signaling. Lat/et acts as a dominant negative Dome co-receptor. Suppressor of cytokine signaling (SocS) (Socs36e, Socs44A) prevents Stat92e recruitment onto the receptor. protein inhibitors of activated STAT (piAS) and pTp61F inhibit Stat92e function. Sumoylation of Stat92e has a repressive role in the regulation of the JAK-STAT pathway in Drosophila. BcL6 (Ken and Barbie, marked Ken) and NuRF compete with Stat92e for binding to DNA.

The JAK-STAT signaling pathway in Drosophila melanogaster. (A) Activation of JAK-STAT signaling. Binding of either cytokine, unpaired (upd1, 2, and 3), to the type i cytokine receptor Domeless activates trans-phosphorylation of the JAK kinase Hopscotch (Hop) and Dome phosphorylation, creating a docking site for STAT (Stat92e). Hop-phosphorylated STAT forms dimers which translocate into the nucleus and activate target genes via binding to TTcN (3-4)GAA sites. The green box in Dome corresponds to the cytokine binding domain (cBM), the blue box to a conserved region between Lat/et and Dome (LDHR), the fibronectin iii (Fn iii) motifs are in red, the signal peptide in yellow and the intra-cytoplasmic region in gray. (B) Negative regulation of JAK-STAT signaling. Lat/et acts as a dominant negative Dome co-receptor. Suppressor of cytokine signaling (SocS) (Socs36e, Socs44A) prevents Stat92e recruitment onto the receptor. protein inhibitors of activated STAT (piAS) and pTp61F inhibit Stat92e function. Sumoylation of Stat92e has a repressive role in the regulation of the JAK-STAT pathway in Drosophila. BcL6 (Ken and Barbie, marked Ken) and NuRF compete with Stat92e for binding to DNA.

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Reference

The JAK-STAT pathway in blood cell formation and immunity - Scientific Figure on ResearchGate. Available from: https://www.researchgate.net/figure/The-JAK-STAT-signaling-pathway-in-Drosophila-melanogaster-A-Activation-of-JAK-STAT_fig1_257075961 [accessed 30 Jun, 2024]

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Figure 1. The JAK-STAT signaling pathway in Drosophila melanogaster. (A) Activation of JAK-STAT signaling. Binding of either cytokine, unpaired (upd1, 2, and 3), to the type i cytokine receptor Domeless activates trans-phosphorylation of the JAK kinase Hopscotch (Hop) and Dome phosphorylation, creating a docking site for STAT (Stat92e). Hop-phosphorylated STAT forms dimers which translocate into the nucleus and activate target genes via binding to TTcN (3-4)GAA sites. The green box in Dome corresponds to the cytokine binding domain (cBM), the blue box to a conserved region between Lat/et and Dome (LDHR), the fibronectin iii (Fn iii) motifs are in red, the signal peptide in yellow and the intra-cytoplasmic region in gray. (B) Negative regulation of JAK-STAT signaling. Lat/et acts as a dominant negative Dome co-receptor. Suppressor of cytokine signaling (SocS) (Socs36e, Socs44A) prevents Stat92e recruitment onto the receptor. protein inhibitors of activated STAT (piAS) and pTp61F inhibit Stat92e function. Sumoylation of Stat92e has a repressive role in the regulation of the JAK-STAT pathway in Drosophila. BcL6 (Ken and Barbie, marked Ken) and NuRF compete with Stat92e for binding to DNA.

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<a href="https://www.researchgate.net/figure/The-JAK-STAT-signaling-pathway-in-Drosophila-melanogaster-A-Activation-of-JAK-STAT_fig1_257075961"><img src="https://www.researchgate.net/publication/257075961/figure/fig1/AS:616375517204489@1523966783905/The-JAK-STAT-signaling-pathway-in-Drosophila-melanogaster-A-Activation-of-JAK-STAT.png" alt="The JAK-STAT signaling pathway in Drosophila melanogaster. (A) Activation of JAK-STAT signaling. Binding of either cytokine, unpaired (upd1, 2, and 3), to the type i cytokine receptor Domeless activates trans-phosphorylation of the JAK kinase Hopscotch (Hop) and Dome phosphorylation, creating a docking site for STAT (Stat92e). Hop-phosphorylated STAT forms dimers which translocate into the nucleus and activate target genes via binding to TTcN (3-4)GAA sites. The green box in Dome corresponds to the cytokine binding domain (cBM), the blue box to a conserved region between Lat/et and Dome (LDHR), the fibronectin iii (Fn iii) motifs are in red, the signal peptide in yellow and the intra-cytoplasmic region in gray. (B) Negative regulation of JAK-STAT signaling. Lat/et acts as a dominant negative Dome co-receptor. Suppressor of cytokine signaling (SocS) (Socs36e, Socs44A) prevents Stat92e recruitment onto the receptor. protein inhibitors of activated STAT (piAS) and pTp61F inhibit Stat92e function. Sumoylation of Stat92e has a repressive role in the regulation of the JAK-STAT pathway in Drosophila. BcL6 (Ken and Barbie, marked Ken) and NuRF compete with Stat92e for binding to DNA."/></a>