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Source publication
Objectives:
To investigate the effect of Jintiange capsule on acute bone atrophy (vertebral height, Cobb's angle, bone mineral density, and visual analog score (VAS) in patients with osteoporotic vertebral compression fracture.
Methods:
A total of 106 patients with osteoporotic vertebral compression fractures were selected and randomly divided i...
Citations
... 14,15,23 In addition, our results showed that the improvement of bone metabolism marker levels in the study group was better than that in the control group after the treatment, which suggests that the combination of Danshen injection, calcitriol, and calcium/Vitamin-D can effectively improve osteoporosis fractures of patients, aiding in their functional recovery. 24,25 Both calcitriol and calcium/Vitamin-D can directly increase patient's levels of calcium and Vitamin-D. Danshen injection has been reported to promote osteoblast proliferation, regulate bone calcium release, increase bone mass, improve bone metabolism, shorten the fracture recovery process, and enhance disease treatment effectiveness. ...
Objective
To explore the efficacy of Danshen injection combined with calcitriol and calcium/Vitamin-D in the treatment of osteoporotic fractures.
Methods
This was a case–control study. We retrospectively reviewed clinical data of 91 patients with osteoporotic fractures who received treatment in Rui’an People’s Hospital from February 2021 to July 2022. The data were divided into a control group with 44 records of patients who received treatment with calcitriol and calcium/Vitamin-D, and a study group with 47 patients who received Danshen injection combined with calcitriol and calcium/Vitamin-D. The control group individuals were coordinated with the patients in terms of their age and gender. Treatment effects, inflammatory response levels, and bone metabolic status levels were comparable between the two groups before and after the treatment.
Results
The total efficacy of the treatment in the study group was better than that in the control group (P<0.05). After the treatment, levels of serum inflammatory factors in both groups decreased compared to those before the treatment, and the study group displayed lower levels than the control group (P<0.05). After the treatment, the bone metabolism status of both groups improved, and the improvement effect of the study group was better (P<0.05). The incidences of adverse reactions were similar in both groups (P>0.05).
Conclusions
Danshen injection combined with calcitriol and calcium/Vitamin-D for the treatment of osteoporotic fractures can effectively reduce inflammation, regulate bone metabolism, and improve fracture treatment efficacy with a favorable safety profile.
... To meet the medical demand, artificial tiger bone powder has been developed to substitute natural tiger bone, and its structure closely resembles that of natural tiger bone (16,17). Several clinical studies have indicated that multiple organic constituents of Jintiange capsules, such as amino acids, calcium, magnesium, phosphorus, iron, copper, manganese, and zinc, can improve bone formation, inhibit bone absorption, and accelerate the metabolism to absorb calcium for the postoperative treatment of OVCFs (18,19). Although Jintiange capsules have been regarded as an effective Chinese patent medicine for patients with OVCFs in China and are recommended in Chinese OP treatment guidelines, there is currently a lack of high-quality evidence regarding the efficacy of Jintiange capsules in the treatment of OVCFs (20). ...
... Next, we eliminated 102 articles by scanning the titles and abstracts. After applying the inclusion and exclusion criteria, the full text of the 42 studies met the requirement with the Jintiange Capsule, of which 16 studies on the postoperative treatment of patients with OVCFs ultimately met the inclusion criterias of this meta-analysis (18,(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38). Figure 1 shows the search process and selection details. ...
... Nine studies (18,24,25,27,31,(33)(34)(35)38) showed percentage changes in the effective rate. The test for the overall effect of these nine studies showed that Jintiange capsules significantly improved the effective rate in contrast with control groups (RR = 1.14, 95% CI: Risk of bias summary of the 16 included studies. ...
Background
In traditional Chinese medicine, Jintiange capsules are frequently used to treat metabolic bone diseases and strengthen bones and tendons. The main component of Jintiange capsules is bionic tiger bone powder. However, the active ingredients and proteins are derived from other animal bones, with chemical profiles similar to that of natural tiger bone. This study aimed to explore the efficacy of Jintiange capsules, a Chinese herbal medicine, in the postoperative treatment of osteoporotic vertebral compression fractures (OVCFs).
Methods
In this systematic review, literature was retrieved using PubMed, the Cochrane Library, the Chinese National Knowledge Infrastructure, the Web of Science, the Wanfang Database, the Chinese Biomedical Literature Database, and the Chinese VIP Database from inception to July 2023. The primary outcome measures were the bone mineral density (BMD) and effective rate. The secondary outcome measures were the visual analog pain score (VAS), Oswestry disability index (ODI), Cobb’s angle, serum osteocalcin, serum alkaline phosphatase, and adverse events. RevMan 5.4 and STATA 17.0 software were used for data analysis.
Results
We enrolled randomized controlled trials (RCTs) focusing on 1,642 patients in the meta-analysis. The meta-analysis illustrated that Jintiange capsules significantly increased the BMD of the lumbar spine ( p < 0.00001), femoral neck ( p = 0.0005), and whole body ( p = 0.01). The subgroup analysis of Jintiange capsules combination therapy showed that the BMD of the lumbar spine and whole body was significantly improved with Jintiange capsules ( p < 0.00001). The test for the overall effect showed that Jintiange capsules had a significantly higher effective rate than the control groups ( p = 0.003). Additionally, the overall effect test showed that Jintiange capsules decreased the VAS and ODI ( p < 0.00001) and Cobb’s angle ( p = 0.02), and improved serum OC and ALP ( p < 0.00001) compared with the controls. Furthermore, the pooled analysis of adverse reactions showed no serious impacts on the treatment of OVCFs.
Conclusion
Jintiange capsules demonstrate high safety and efficacy in the treatment of OVCFs, including increasing BMD, the lift effect rate, serum OC levels, and pain relief, decreasing the ODI, serum ALP levels, and adverse events, and improving Cobb’s angle. Additional research is required to validate the efficacy of Jintiange capsules for the postoperative treatment of OVCFs.
Systematic review registration : https://www.crd.york.ac.uk/PROSPERO .
... The VAS (Visual Analog Score) is a commonly used tool for evaluating back pain. The scale ranges from 0 to 10 (Shu and Zhang, 2022), with a higher score indicating greater pain intensity. Participants will be asked to rate their pain weekly before follow-up, and the levels of pain intensity will be categorized as none (0), mild (1-3), moderate (4-6), and severe (7-10) (Liu et al., 2022). ...
Introduction
Chronic non-specific low back pain (CNLBP) is a complex condition characterized by pain, dysfunction, disturbed sleep, anxiety, and depression, all of which impair the quality of life. Previous studies showed that practicing Tai Chi had effects on chronic low back pain. However, there is a lack of evidence on its impact on sleep. The trial will evaluate the use of Tai Chi as a treatment for insomnia in elderly people with CNLBP.
Methods
The study design will be a randomized, controlled, open-label trial. Participants (n = 106) will be recruited from the Hospital of Chengdu University of Traditional Chinese Medicine, Qing Yang District University for the Elderly, and Ci Tang Street Community. Participants will be randomly assigned to the Tai Chi group (n = 53) and the control group (n = 53). The Tai Chi group will undergo a Yang-style 24-form Tai Chi program for 8 weeks. The control group will have a waiting period of 8 weeks, followed by 8 weeks of Tai Chi practice. The primary outcomes of this study will be changes in sleep quality and pain intensity. Secondary outcomes of interest will include changes in the quality of pain, range of motion, physical performance, social support, and overall quality of life. Any adverse events and attendance rates will also be reported in this study.
Clinical trial registration
ChiCTR2200064977.
The aging global population is increasingly affected by osteoporosis (OP), which is one of the most significant threats to the elderly. Moreover, its prevention and treatment situations have become increasingly severe. Therefore, it is imperative to develop alternatives or complementary drugs for preventing and treating osteoporosis. Kidney tonifying traditional Chinese medicine (KTTCM) has been used for the treatment of osteoporosis for a long time. Pharmacological studies have shown that kidney tonifying traditional Chinese medicine can promote osteoblasts, inhibit osteoclasts, and regulate the level of estrogen and plays vital roles in stimulating osteogenesis, restraining adipogenesis of marrow mesenchymal stem cells (MSCs), regulating the metabolism of calcium and phosphorus, and inhibiting oxidative stress. These effects are mediated by OPG/RANKL/RANK, BMP/Smads, MAPKs, and Wnt/β-catenin systems. To develop a safe, synergistic, effective, and homogenized TCM formula with robust scientific evidence to provide faster and more economical alternatives, the anti-osteoporosis ingredients and pharmacological mechanisms of kidney tonifying traditional Chinese medicine are recapitulated from the perspective of molecular and cell biology, and the safety and toxicity of kidney tonifying traditional Chinese medicine have also been reviewed in this paper.
