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The Cross of Lorraine
Source publication
The Canadian Association for the Prevention of Consumption and Other Forms of Tuberculosis, parent to both the Canadian Tuberculosis Association and the Canadian Lung Association (CLA) with its medical arm, the Canadian Thoracic Society (CTS), carried the Cross of Lorraine (Figure 1) and the crusade against tuberculosis (TB) in Canada during the tw...
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Citations
In Canada, tuberculosis (TB) rates are at a historic low, with the remaining risk concentrated in a few vulnerable population subgroups.
To describe the epidemiology of TB in the Canadian province of Ontario and to characterise risk factors associated with transmission events, identified using genetic typing techniques.
Retrospective analysis of 2186 culture-positive TB cases between August 2007 and December 2011. Temporal trends and risk of spatiotemporal and genotypic clustering were evaluated using Poisson and logistic regression models.
Being in a spatiotemporal cluster was associated with Aboriginal status (odds ratio [OR] 3.63, 95% confidence interval [CI] 1.23-10.71). Cases in genotypic clusters were more likely to report homelessness as a risk factor (adjusted OR [aOR] 2.92, 95%CI 1.74-4.90) or be male (aOR 1.35, 95%CI 1.09-1.68), and were less likely to be aged ≥65 years (aOR 0.63, 95%CI 0.49-0.82), foreign-born (aOR 0.32, 95%CI 0.24-0.43) or Aboriginal (aOR 0.40, 95%CI 0.16-0.99). The Beijing lineage had an annual rate of increase of almost 10% (P = 0.047), and was associated with genotypic clustering (aOR 2.84, 95%CI 2.19-3.67).
Genotypic data suggest that disease clusters are smaller, but far more common, than would be estimated using spatiotemporal clustering.
