Figure - available from: Frontiers in Neuroinformatics
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The CT examination of one patient with cerebral contusion and laceration with intracerebral hematoma.
Source publication
Objectives:
To investigate the clinical value of non-invasive ultrasound imaging in the evaluation of brain death caused by traumatic brain injury.
Methods:
Thirty-four patients with acute severe traumatic brain injury were admitted to hospital within 48 h after injury. All patients were monitored intracranial pressure, transcranial Doppler, ech...
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Background
Diagnosing brain death (BD) with accuracy and urgency is of great importance because an early diagnosis may guide the clinical management, optimize hospital beds, and facilitate organ transplantation. The clinical diagnosis of nonreactive and irreversible coma can be confirmed with additional tests. Among the complimentary exams that may...
Citations
... In the middle and late 20th century, foreign neurologists used ice cubes and cryogenic beds and infusion of medicine to make patients hibernate and reduce their temperature to 32°C to 35°C to slow down the development of the disease and strive for treatment time. [17] It has been recorded those dozens of hospitals in the world have used this kind of treatment like hypothermic hibernation for more than 100 patients with STBI. [18,19] Most of the doctors involved in the study hold that lowering the temperature of patients can promote the recovery of severe TBI. ...
This study is to explore the application of target temperature management and therapeutic hypothermia in the treatment of neuroprotection patients with severe traumatic brain injury and its effect on oxidative stress. From February 2019 to April 2021, 120 patients with severe traumatic brain injury cured were selected in our hospital. The patients were randomly divided into control and experimental groups. The control group accepted mild hypothermia therapy. The experimental group took targeted temperature management and mild hypothermia therapy. This study compared the prognosis, National Institute of Health Stroke Scale (NIHSS) score, oxidative stress level, brain function index and the incidence of complications in different groups. The prognosis of the experimental group was better (P < .05). After treatment, the NIHSS score lessened. The NIHSS score of the experimental group was lower at 3 and 6 weeks after treatment (P < .05). Following treatment, the level of superoxide dismutase-1 in the experimental group was higher and the level of malondialdehyde was lower (P < .05). After treatment, the brain function indexes of patients lessened. The experimental group's myelin basic protein, neuron specific enolase and glial fibrillary acidic protein indexes were lower (P < .05). The incidences of pendant pneumonia, atelectasis, venous thrombosis of extremities and ventricular arrhythmias in the experimental group were remarkably lower (P < .05). Targeted temperature management and mild hypothermia treatment can improve neurological function, maintain brain cell function, and reduce stress-reactions risk. The incidence of complications during hospitalization was reduced.
... Abnormal cerebral blood flow parameters can reflect the severity of brain injury and affect intellectual development [18,19]. According to relevant studies, children with cerebral palsy with cerebral microcirculation disorders have slow cerebral artery blood flow and increased vascular resistance, which further influences dysgnosia [20]. Cerebral blood flow velocity is closely related to changes in local cerebral blood flow. ...
Objective. This study is aimed at researching transcranial magnetic stimulation (TMS) effects combined with computer-aided cognitive training (CACT) on cognitive function of children suffering from cerebral palsy and dysgnosia. Methods. From December 2019 to October 2021, 86 children with cerebral palsy and dysgnosia who were treated at our hospital were recruited and assigned into observation and control groups (n=43, each) using the random number table technique. The observation group received TMS combined with CACT (TMS+CACT), whereas the control group received only TMS. Chinese Wechsler Young Children Scale of Intelligence (C-WYCSI) and Chinese-Wechsler Intelligence Scale for Children (C-WISC) were used to evaluate the intelligence level of the two groups; Gross Motor Function Measure-88 (GMFM-88) of Fudan Chinese version was employed for evaluating the gross motor function of the two groups; a comparison was drawn among the two groups for the cerebral hemodynamic parameters before and after the treatment. Results. For young children, the verbal intelligence quotient (VIQ) scores at 6 and 12 weeks of treatment in the observation group were increased when compared to those in the control group (48.91±3.70 vs. 47.32±3.33, 54.25±4.46 vs. 49.48±3.36), and the observation group’s performance intelligence quotient (PIQ) score at 12 weeks of treatment was higher as to that of the control group (65.38±4.23 vs. 62.81±4.74, all P
... The term "main cerebral blood flow" is also used to characterize the TCD object. It is generally accepted (Al-Mufti et al., 2018;Niu et al., 2020) that TCD in TBI is most often used to diagnose hypoperfusion, hyperemia, vasospasm, and cessation of cerebral blood flow in the brain death. ...
TCD is a portable, repeatable, non-invasive technique in the bedside assessment and monitoring of cerebral blood flow with high temporal resolution. Since its introduction into neurological practice in the 1980s, transcranial Doppler ultrasonography has become an indispensable method of non-invasive examination of the cerebral circulation and an indispensable tool in emergency neurology. In the current review, we presented the principles and technical nuances of the use of TCD, as well as the indispensability of TCD in the treatment of patients with traumatic brain injury. We have studied the usefulness of this tool for assessing hypoperfusion, the development of cerebral vasospasm, non-invasive determination of intracranial pressure (ICP), and predicting the patient’s outcome at TBI, as well as studying the state of cerebral autoregulation.
