Figure 3 - available via license: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
Content may be subject to copyright.
The Aspartate metabolism pathway. Oxaloacetate produced from the TCA cycle is converted into aspartate. Aspartate will then be broken down to produce threonine, isoleucine, methionine, and lysine.
Source publication
Recent research has been conducted to find potential new avenues of drug discovery for treating tuberculosis infection. This endless “arms race” is due to the ability of the bacteria to develop resistance towards the already established antibiotic regimen. Various pathways within Mycobacterium tuberculosis are being studied extensively to open new...
Contexts in source publication
Context 1
... pathway is a promising avenue for looking for potential drug targets since it is absent in humans (Viola, 2001). The process starts with oxaloacetate produced from the tricarboxylic acid (TCA) cycle (Figure 3), which is converted into aspartate by aspartate aminotransferase (rv3722c). Afterwards, aspartate kinase (ASK) converts aspartate into aspartyl-phosphate (AP). ...
Context 2
... third step is the conversion of AP into aspartate semialdehyde, the first of two intermediates that serve as a branch point in the pathway. Finally, it will be catabolized further to produce either methionine/threonine or lysine, depending on which enzyme catalyzes the reaction ( Figure 3). Aspartate will then be broken down to produce threonine, isoleucine, methionine, and lysine. ...
Context 3
... back to the first branch, the enzymatic action of dihydrodipicolinate synthase (dapA) on aspartate semialdehyde leads to lysine metabolism since it converts aspartate semialdehyde into dihydrodipicolinate ( Figure 3). Further catabolism processes ensue, which ends in the biosynthesis of lysine ( Usha et al., 2016). ...
