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Syringocystadenoma papilliferum in the superficial part of the lesion. Tubular apocrine adenoma and cystic dilate glands in the deeper part.
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Nevus sebaceus of Jadassohn is a congenital cutaneous hamartoma comprised of multiple skin structures. It has the potential to develop into variety of neoplasms of various epidermal adnexal origins. While multiple tumors may occasionally arise, it is unusual for more than four tumors to arise simultaneously within a single sebaceus nevus. Here in,...
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Syringocystadenoma papilliferum also known as syringocystadenomatosus papilliferus is a benign adnexal skin tumor presenting as exuberant proliferating lesion of apocrine or eccrine type of differentiation. It is said to be common at birth or during puberty but cases in adults have also been reported. It typically develops as a nodular plaque lesio...
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... 4 There are reported cases of multiple lesions derived from nevus sebaceus, such as syringocystadenoma papilliferum, trichoblastoma, tubular apocrine adenoma, sebaceoma, follicular infundibulum tumor, and epithelioma with sebaceous differentiation. 5 However, the neoplasm described in the present report is even more uncommon, and its difference lies in the intratumor melanocytic proliferation and not only the presence of pigment. ...
... Nevus sebaceous of Jadassohn (NSJ), first described by Joseph Jadassohn in 1895, is an organoid nevus of pilosyringosebaceous and adnexal origin that combines sebaceous gland abnormalities with anomalies of the epidermal, follicular, and apocrine glands (1,2). ...
... NSJ follows three phases of its natural history designated by Mehregan and Pinkus (8) as infancy, pubertal stimulation, and post-pubertal histological degeneration; usually appears at birth (0.1-0.3% among newborns) or early childhood as a wellcircumscribed, smooth, slightly raised, yellowish-brown alopecic patch that progresses through puberty, assuming a more verrucous texture, possibly due to the expression of various hormonal receptors (4). There have been only a few reported cases in the literature describing the simultaneous development of 5 or more neoplasms in a solitary lesion (2). ...
... Its clinical importance lies mostly in the potential for neoplastic transformation with an estimated incidence of 10% to 30% [1]. Although multiple neoplasms may occasionally arise within the same lesion, only four reports in the English literature describe the simultaneous emergence of five or more neoplasms [1][2][3][4]. We report the first case of seven secondary benign tumors within a single NSJ. ...
... The basaloid features and peripheral palisading in TFI may be similar to a superficial BCC or superficial portion of an infundibulocystic BCC. In contrast to BCC, the tumor cells in TFI are pale staining due to glycogen and lack hyperchromatic nuclei, peripheral clefting, and Ber-EP4 expression [2]. They may also include scattered CK20positive Merkel cells, which are usually absent in BCC [20]. ...
Nevus sebaceous of Jadassohn is a congenital cutaneous hamartoma with epidermal, sebaceous, follicular, and apocrine structures that usually appears at birth or in early childhood. It has the potential to generate a variety of secondary neoplasms of different lineages, and the risk increases with patient age. Although multiple neoplasms may occasionally arise within the same lesion, the coexistence of more than five secondary tumors is extremely rare. Here we report a case of seven secondary tumors including syringocystadenoma papilliferum, desmoplastic trichilemmoma, sebaceoma, trichoblastoma, pigmented trichoblastoma, sebaceous adenoma, and tumor of follicular infundibulum arising within a nevus sebaceous. The complete diagnosis relies on the histopathological analysis of multipoint biopsies and delicate pathological sections.
... The incidence of basal cell carcinoma and other malignant neoplasms is considered relatively low, occurring in less than 1% of cases. [1][2][3] The risk of developing secondary tumors in childhood is extremely unusual, occurring in less than 2% of children with nevus sebaceous, and at birth is even rarer. 4 We report 2 unrelated cases of congenital secondary tumors from nevus sebaceous, both with extensive cutaneous lesions, but without evidence of internal manifestations. ...
... The lesion may present at birth, develop in puberty, and develop secondary tumors in adulthood. 1 Most secondary tumors associated with NS are benign, and a single NS rarely develops into more than one secondary skin tumor. 2,3 The most common benign secondary tumor is trichoblastoma, followed by syringocystadenoma papilliferum (SCAP). ...
Nevus sebaceous (NS) is a benign congenital hamartoma with the potential to develop into a secondary benign or malignant skin tumors. Two or more skin tumors rarely arise simultaneously from a single NS lesion. Herein, we report a case of syringocystadenoma papilliferum and basal cell carcinoma arising in an NS, based on dermoscopic, reflectance confocal microscopic, and histopathological findings.
... However, our review of the literature revealed a single case report describing six unique neoplasms found in a single lesion. 6 Malignant secondary tumor transformation has been observed almost exclusively in adults, with a recent retrospective analysis of 707 cases showing that patients over the age of 18 account for 96% of transformations, with the remaining 4% of cases among patients aged 11 to 17. 3 The primary treatment modalities for nevus sebaceus are either close clinical observation or surgical excision, but no definitive consensus exists on the excision timeline of nevus sebaceus. Some suggest that the complications of excision are more prevalent during childhood and thus surgical excision should be delayed until adulthood if possible. ...
Nevus sebaceus is a congenital hamartoma associated with several secondary tumors. We report the case of a 19-year-old woman who presented with changes in a nevus sebaceus lesion on her parietal scalp, which was subsequently excised. Upon pathological examination, both basaloid hamartoma and syringocystadenoma papilliferum were noted within the specimen, which is rare. The primary treatment modalities for nevus sebaceus are either close clinical observation or surgical excision, but no definitive consensus exists on the excision timeline of nevus sebaceus.
... These basaloid cell islands show peripheral palisading without an epidermal connection and are separated by fibrous stroma arranged in cords, sheets, or lobules. [9] TBL is divided into five major histological patterns which include large nodular (including pigmented), small nodular, cribriform, racemiform, and retiform. Less common forms like adamantoid, columnar, rippled, subcutaneous and superficial forms have also been described. ...
... Less common forms like adamantoid, columnar, rippled, subcutaneous and superficial forms have also been described. [9] The diagnosis of its variants depends upon the association with pigmentation and arrangement of cells. As per literature pigmented variants of TBL are very rare. ...
... Only few cases have been reported till date. [9][10][11] However, in our series the most common variant we saw was pigmented TBL. Malignant alteration and aggressive features in TBLs can lead to BCC or trichoblastic carcinoma, [12] but this is rare. ...
Purpose: This study aims to explore the clinicopathological features of a rare eyelid tumor, trichoblastoma (TBL). Methods: This is a retrospective study of patients undergoing excision biopsies of eyelid masses at a tertiary eye care center in South India, between January 2017 and December 2018. Patient demographics, clinical and differentiating histopathological features, and recurrence of TBL were studied. Results: Amongst all eyelid masses, 15 were histopathologically diagnosed with TBL. The average age at presentation was 64 years as female preponderance and average duration of mass being 786 days. Change in color was noted in three patients, change in size in 14 cases and history of bleeding from the mass in three. Lower lid was the most common site involved (eight patients). The average dimension of the lesions was 158.67 mm2. One patient had lid margin involvement with loss of lashes noted in three cases and conjunctival involvement in three patients. Morphologically, eight lesions were nodular while five were noduloulcerative. Pigmented TBL was noted in eight patients, TBL with atypia in three patients. TBL, malignant TBL, rippled variant and TBL with trichofolliculoma were noted in one patient each. Clinical and histopathological diagnoses correlated in four patients. No recurrence was noted with the maximum follow-up period being 23 months. Conclusion and Relevance: A differential diagnosis of TBL should be kept in mind while managing eyelid tumors because benign lesions can mimic commonly diagnosed malignancies and vice versa.
... [4] including a syringocystadenoma papilliferum, pigmented trichoblastoma, tubular apocrine adenoma, sebaceoma, tumor of the follicular infundibulum and superficial epithelioma with sebaceous differentiation arising in a long-standing NS on the scalp in a 70-year-old man. [6] Additionally, a case of trichilemmoma, desmoplastic trichilemmoma and BCC arising from NS was reported by Lee et al. [7] [ Table 1] Available treatment options for trichilemmoma and NS range from simple surgical excision to carbon dioxide laser tissue ablation. However, carbon dioxide laser has the advantage of precise tissue ablation with minimal morbidity and multiple lesions can be treated easily. ...
... Nil. [7] Desmoplastic trichilemmoma, Basal cell carcinoma 61 years/Male Jardim et al. (2016) [5] Desmoplastic trichilemmoma 58 years/ Female Gozel et al. (2013) [6] Syringocystadenoma papilliferum, Pigmented Trichoblastoma, Tubular apocrine adenoma, Sebaceoma, Tumor of follicular infundibulum and Superficial Epithelioma with nevus 70 years/Male ...
... Nil. [7] Desmoplastic trichilemmoma, Basal cell carcinoma 61 years/Male Jardim et al. (2016) [5] Desmoplastic trichilemmoma 58 years/ Female Gozel et al. (2013) [6] Syringocystadenoma papilliferum, Pigmented Trichoblastoma, Tubular apocrine adenoma, Sebaceoma, Tumor of follicular infundibulum and Superficial Epithelioma with nevus 70 years/Male ...
... And also, immunohistochemistry may sometimes helpful to differentiate the two. [8] Pitarch and Botella-Estrada [9] used dermoscopy revealed that the branching telangiectases were wider in caliber and tended to branch more in nodular BCC compared with TB and other benign cutaneous tumors. Hence, dermoscopy may be used as an effective and noninvasion method to differentiate TB and BCC. ...
... NS frequently accompany with benign and malignant tumors, and it is difficult to identify them only by clinical feature, so it may be significant to do prophylactic complete excision or local photodynamic therapy at early stage of NS. [8] Otherwise, close clinical follow-up is necessary. ...
Nevus sebaceous (NS) is a clinically common benign tumor and has a high potential to develop into a great diversity of neoplasms of epidermal and adnexal origins. However, it is a rare phenomenon of the coexistence in a single NS with two or more skin tumors. We report a case of a 58-year-old woman with two kinds of neoplastic proliferation including syringocystadenoma papilliferum and trichoblastoma arising in NS on the scalp. © 2018 Indian Journal of Pathology and Microbiology. All rights reserved.
... Actually, this rate is less than 1% of cases. Development of six different tumours has also been reported in one solitary lesion [88]. ...
This chapter reviews common cutaneous infections, infestations, and neoplasms of the scalp. Infections of the scalp are subdivided into three major groups. The most seen are: (1) Bacterial: Folliculitis, folliculitis decalvans, tufted hair folliculitis and acne keloidalis nuchae. (2) Fungal: Tinea capitis, favus and kerion celsi. (3) Protozoal: Syphilitic alopecia. Pediculosis capitis is the most common worldwide infestation of the scalp. The neoplasms of the scalp are large group of different diseases due to arising different origin. In the following section, trichilemmal cyst, proliferating trichilemmal cyst, nevus sebaceous and cylindroma are discussed in detail.
From the site of inoculation, the fungal hyphae grow centrifugally in the stratum corneum. According to the patterns of contamination, tinea of the scalp is classified into two types: ectothrix and endothrix. In an ectothrix infection, the fungi continue downward growth into the follicle and they invade the keratin part of the hairs. Ectothrix invasion is usually associated with Trichophyton verrucosum, Trichophyton mentagrophytes and all Microsporum species. The endothrix hair invasion caused by Trichophyton tonsurans and Trichophyton violaceum is characterised by the development of the fungi within the hair shaft only. While the ectothrix-infected hairs can be of fluoresce bright green or yellow green caused by the destruction of the cuticle of the hair, the endothrix infection do not fluoresce, because the cuticle of the hair remains intact in endothrix infection. The hair is very fragile and breaks the surface of the scalp. Therefore, leaves the infected dark stubs visible in the follicular orifices. Thus, endothrix infection is often described as a ‘black dot’ appearance [37].
