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![Fig. 3 Mass Spectra of [Zn(C 12 H 10 N 5 O 2 Cl)Cl 2 ].](profile/Sabir-Ali-4/publication/324815923/figure/fig2/AS:643809146851328@1530507470304/Mass-Spectra-of-ZnC-12-H-10-N-5-O-2-ClCl-2_Q320.jpg)
The complexes of Co(II), Ni(II), Cu(II) and Zn(II) metal ions has been synthesized through template method by the condensation of succinic acid dihydrazide with 5-chloroisatin in alcoholic medium. Complexes were characterized by C H N analysis, molar conductance, thermal analysis, magnetic susceptibility, mass spectrometry, FTIR, EPR, ¹H NMR, UV–Vi...
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Context 1
... synthesized complexes were colored, soluble in DMSO and DMF, non-hygroscopic and non-electrolytic nature in DMSO (Molar Conductance, 6.48-14.27 O À1 cm 2 mole À1 ) [29]. On the basis of various analytical study the synthesized complexes may be written by [M(C 12 H 10 N 5 O 2 Cl)X 2 ] as given in Fig. 1. Here, M = divalent metal ion and X = Cl À , NO 3 À or CH 3 - COO À ion. The spectroscopic and magnetic studies conclude octahedral geometry of the complexes. The elemental analysis results agree well with the calculated values of elements and results are listed in Table ...
Context 2
... synthesized complexes were colored, soluble in DMSO and DMF, non-hygroscopic and non-electrolytic nature in DMSO (Molar Conductance, 6.48-14.27 O À1 cm 2 mole À1 ) [29]. On the basis of various analytical study the synthesized complexes may be written by [M(C 12 H 10 N 5 O 2 Cl)X 2 ] as given in Fig. 1. Here, M = divalent metal ion and X = Cl À , NO 3 À or CH 3 - COO À ion. The spectroscopic and magnetic studies conclude octahedral geometry of the complexes. The elemental analysis results agree well with the calculated values of elements and results are listed in Table ...
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Citations
... Abd-Elzaher evaluates the antimicrobial activity of cobalt(II) complex containing acetylferrocene with 2-aminophenol moiety [17]. Other cobalt complexes have also shown remarkable biological activity [18][19][20][21]. ...
The present study was carried out to investigate the effect of substituent groups on the antibacterial activities of 2-aminophenol Schiff bases and their cobalt (II) complexes. Development of new compounds with potential effects against pathogenic organisms has become necessary due to the increase in microbial resistance reported for existing antiseptics and disinfectants. In line with this, new cobalt (II) complexes with Schiff bases derived from 2-aminophenol and p-substituted benzaldehydes were synthesized. The compounds were characterized using elemental analysis, mass spectrometry, atomic absorption spectroscopy, electrospray ionization mass spectrometry, infrared spectroscopy, 1H NMR and electronic absorption spectroscopy. Results indicate that all metal complexes had a 1:2 metal ligand ratio with magnetic moments characteristic of tetrahedral geometry around the metal ion. The Schiff bases and their metal complexes were screened for in-vitro antibacterial activities against 6 human pathogenic bacteria usually found around the hospitals and homes; Escherichia coli (ATCC 8739), Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 19582), Bacillus cereus (10702), Enterococcus faecalis (ATCC 29212) and Kribsella pneumonia (ATCC 10031) with ampicillin used as the reference compound. DNA binding study using calf thymus DNA revealed intercalative mode of activity. The result showed that Schiff bases exhibited moderate inhibitory activity against the tested microorganisms while Schiff base metal complexes exhibited higher antibacterial activity when compared to ampicillin. Our results indicate that these complexes can be employed as active ingredients in development of broad-spectrum antibacterial agents.
... Hydrazide derivatives of dicarboxylic acids are widely used as drugs with antimicrobial, antifungal, antibacterial, and antitubercular activity [1][2][3][4][5][6]. Among the substituted hydrazides of succinic acid, compounds with hypoglycemic and hypertensive effects were found [7]. ...
Dicarboxylic acid dihydrazides are widely used as pharmaceutical intermediates, plant growth regulators, water-based coating additives, epoxy crosslinking agents. Dihydrazides are prepared by adding hydrazine hydrate to an acid halides and diesters. In this work the hydrazinolysis of succinic acid was studied using various ion exchange resins as catalysts, and the optimum conditions and the reaction mechanism were identified. Analysis of the initial reagents and the target product were performed out using photocolorimetric and IR spectroscopic methods, the composition of the target product was determined by elemental analysis. Hydrazinolysis of succinic acid were performed in aqueous medium in the temperature 90 °C for 3 h. Succinic acid conversion was 82–95 %, and the succiniyldihydrazide yield 61–93 %. It has been shown the efficient catalysts for the hydrazinolysis of succinic acid are AV-17-8, AN-31 and AN-1 anion exchangers. The highest succinyldihydrazide yield (93 %) was obtained with anion exchanger AV-17-8. On the basis of IR spectroscopic studies, a plausible process mechanism was suggested. A probable mechanism of the process with the formation of supramolecular complexes with the participation of substrates and fixed polymer-bound quaternary ammonium and hydroxyl ions of the anion exchanger was proposed. Thus, the most efficient method of succinic acid dihydrazide preparation has been proposed in comparison with known methods.
... Previous studies suggested that metal complexes also have an antiproliferative property. It accelerates drug action and the efficiency of therapeutic compounds [29]. NM also contains metallic compounds such as mercury, sulfur, red Sulfide of mercury, zinc sulfate, mercurous chloride, mercuric sulfide, arsenic monosulphide, and arsenic trisulphide [5], which may increase its anticancer activity. ...
Cervical cancer is the most common cancer among women of childbearing age. Nandhi Mezhugu is a Siddha herbo-mineral drug widely used to treat cancer. Due to a lack of scientific evidence, the present study was intended to evaluate the anti cancer activity of Nandhi Mezhugu in the HeLa cell line. The cells were cultured in Dulbecco’s modified Eagle medium, then treated with different concentrations of the test drug (10 to 200 µg/ml). The anti proliferative activity of the drug was evaluated using an MTT assay. Cell apoptosis and cell cycle were measured by flow cytometry and typical nuclear changes of apoptotic processes were observed under the microscope using the dual acridine orange/ethidium bromide fluorescent staining method. The study result showed that the percentage of cell viability decreased with an increase in the concentration of the test drug. The MTT assay data showed that the test drug Nandhi Mezhugu had the antiproliferative effect on cervical cancer cells with IC50 of 139.7 ± 13.87 µg/ml. Further studies such as flow cytometry and dual staining method also revealed the apoptotic effect of the test drug. Nandhi Mezhugu can be effectively used as an anti cancer formulation to treat cervical cancer. Thus, the current study brings forth scientific evidence for the efficacy of Nandhi Mezhugu against the HeLa cell line. Further studies will be needed to prove the promising efficacy of Nandhi Mezhugu.
... A basic tendency in the field of plant protection concerns reduction of the usage of pesticides, and their subsequent replacement with environmentally friendly alternatives [1] . Metal ions accelerate the drug action and efficiency of therapeutic compounds [2] . In addition, biologically active ligands are quite important in coordination compounds. ...
... In addition, biologically active ligands are quite important in coordination compounds. Mixed ligand complexes also play a key role in magneto chemistry, analytical chemistry and photochemistry, among others [2,3] . These complexes provide vital information on enzymes, such as their activation. ...
... Additionally, MSB transition metal complexes can process antimicrobial effects in various ways, including by inhibiting the synthesis of microbial cell walls, disrupting microbial membranes and functions, inhibiting the synthesis of nucleic acids and proteins, destroying DNA, denaturing proteins, releasing or exchanging ligands, losing essential substrates, activating redox, suppressing enzymatic activity, and enhancing reactive oxygen species (ROS) production [20]. Moreover, according to Tweedy's chelation hypothesis, chelation/coordination decreases the orientation of metal complexes, enhancing the penetration into bacterial lipid membranes [21]. We are aware that cancer has elevated to the second largest cause of death worldwide in recent years, raising severe health concerns [22]. ...
... It shows MIC against Pseudomonas aeruginosa of 12 μg/mL, equivalent to the standard antibiotic Streptomycin. It also shows the most potent activity against all fungal strains, with a MIC value of [14][15][16][17][18][19][20][21][22] μg/mL [87]. ...
The World is facing an epidemic of various diseases caused by viruses, bacteria, and fungi. Apart from it, cancer, malaria, and diabetes are some major health problems. So, a need arises to discover novel molecules that can be used as therapeutic drugs for several diseases, including cancer and diabetes. Macrocyclic Schiff base (MSB) transition metal complexes are popularly studied organometallic compounds due to their vast biological applications in treating infectious diseases and various health problems. This attracts the researchers to the Chemistry of Schiff base metal complexes in pharmaceutical applications and areas like biochemical, bio-inorganic, environmental, industrial, photochemical, photophysical, photoelectronic etc. So, the Novel synthesis of Schiff base metal complexes will design and develop more effective therapeutic drugs. Even though the topic is quite old and exploited, many researchers are still globally working to find new MSB complexes and their applications. Based on the above considerations, we have reviewed the pharmaceutical properties of MSB transition metal complexes synthesized in the last two decades.
... [8,9] It has been reported that the azomethine linkage and other donor sites present in thiazole ring make it more versatile and flexible in terms of biology, pharmacology, and drug properties. [10][11][12][13] The biological activity of thiazoles is mainly due to their structural similarity with protein imidazole entities [14] and has unique biological, structural, electronic, and spectroscopic characteristics. [15,16] Cu is considered a noble metal for biological functions as it is biocompatible, micronutrient, and cofactor of many enzymes in human body, and moreover, from coordination point of view, it binds considerably with N and O donor ligands. ...
... SCC4 cells have a point mutation codon 51 CCC to TCC. SCC4 was grown in monolayer cultures in Dulbecco's modified Eagle medium (DMEM) MTT assay was performed for cell viability testing as reported in the literature, [11] in which MTT is transformed by living cells to produce a DMSO soluble product (formazan) that can be detected through colorimetric analysis. Different concentrations of ligands, metal complexes, and standard anticancer drug Cisplatin ranging from 5 to 200 μM were treated with SCC4 cell lines for 24 h, 48 h, and 72 h. ...
... This value is calculated by plotting the percentage of cell viability and sample concentration on a logarithmic graph in comparison with the control (not Treated cells). [11] Experiments were performed in triplet, and the final IC 50 value was calculated by taking the average of all. The experiments were also performed by keeping the concentration constant and varying time scale. ...
Present work describes the preparation of Schiff base ligands named 2‐methoxy‐6‐[(E)‐(1,3‐thiazol‐2‐ylimino) methyl] phenol and its structure and activity comparison with another Schiff base N‐[(E)‐pyridin‐2‐ylmethylidene]‐1,3‐thiazol‐2‐amine. Cu (II) complex of both the ligands were prepared in 2:1 ratio in basic medium. UV‐Vis, FTIR, NMR spectroscopy and other physicochemical techniques were used for characterization of synthesized compounds. The FTIR spectra of the ligands and their Cu (II) complexes evident the tetra dentate behavior of ligands and indicates the presence of nitrate groups. The geometry of synthesized ligands and complexes was optimized using density functional theory (DFT) with hybrid B3LYP functional. It confirms that the Cu (II) metal surrounded by tetra dentate ligand moiety was coordinated with oxygen atom of one nitrate group with bond lengths of 1.9668Å for complex 1 and 2.2420Å & 2.6220Å for complex2. Molecular docking study of synthesized molecules was performed against EGFR Kinase (PDB:1m17) and Tyrosine Kinase (PDB:1t46) molecular targets. The complex 1 has shown maximum inhibition with a binding energy of ‐10.40Kcal/mol against 1t46 molecular target. Further, ligand and complexes were analyzed by ADMET study, drug likeness, bioactivity score by using online servers. Since these studies provided very significant results in terms of their binding energy with the target molecules and drug likeness score, time dependent in vitro anticancer activity of all compounds was also tested by using MTT assay against SCC4 cancer cell line. Complex 1has shown promising activity with an IC50 value of 31.1μM at 72h time interval.
... Transition metals are important in the human body and perform several important functions [4]. Over the past decade, transition metals found an increasing use in drug design and development [4][5][6][7][8]. ...
... Herein, we describe the design and synthesis of anthranilic acid metal complexes (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). The metals used in this study are from groups 6-12 [30], in addition to those of bismuth and aluminum [31], whose complexes possess various biological activities. ...
... N 2 -adsorption-desorption isotherms of anthranilic acid metal complexes(1)(2)(3)(4)(5)(6)(7)(8)(9)(10) ...
Background
Anthranilic acid is an active compound with diverse biological activities such as anti-inflammatory, antineoplastic, anti-malarial and α-glucosidase inhibitory properties. It can also chelate transition metals to form complexes with applications as antipathogens, photoluminescent materials, corrosion inhibitors, and catalysts.
Results
Anthranilic acid complexes (1–10) of Zn(II), Bi(III), Ag(I), Fe(II), Co(II), Cu(II), Mn(II), Al, Ni(II), and Cr(III) were synthesized and characterized using thermogravimetric (TGA), elemental analysis, FT-IR, UV–vis spectrometry, mass spectrometry and magnetic susceptibility. The morphology and size of metal complex (1–10) particles were determined by scanning electron microscope (SEM) and the surface area was determined by BET analysis. TGA and CHN analysis data indicated that the stoichiometries of complexes were 1:2 metal/ligand except for Ag(I), Al and Bi. Furthermore, DFT study was performed to optimize the structure of selected complexes. The complexes (1–10) were evaluated for their catalytic activity in the reduction of 4-nitrophenol (4-NP), antibacterial activity against S. aureus, P. aeroginosa and E. coli as well as their antifungal activity against F. solani and A. niger. The complexes were also tested against the second-stage juveniles (J2) root-knot nematodes.
Conclusion
Co(II) complex 5 and Cu(II) complex 6 showed high catalytic activity for the reduction of 4-NP to 4-aminophenol (4-AP). Ag(I) complex 3 showed the best activity against the pathogens that were tested namely clinically important bacteria S. aureus, P. aeroginosa and E. coli, commercially important fungi F. solani and A. niger and J2 root-knot nematodes M. javanica.
... Auto Dock returned the lowest energy cluster for each compound, which was considered and used for further analysis. For the best dock positions, the compound's binding free energy inside the target receptor was calculated [38][39][40]. The best-docked pose's visual representations were obtained using Discovery Studio Visualizer [41] and PyMol [42]. ...
ISSN: (Print) (Online) Journal homepage: https://www.tandfonline.com/loi/gmcl20 Synthesis, crystal structure, computational, and molecular docking studies of bis {1,1'-[1,3,5-Trimethyl-1,3-phenylenebis(methylene)]di-1H-piperidinium}tetrabromide tri hydrate Nayagam (2022) Synthesis, crystal structure, computational, and molecular docking studies of bis {1,1'-[1,3,5-Trimethyl-1,3-phenylenebis(methylene)]di-1H-piperidinium}tetrabromide tri hydrate, Molecular Crystals and Liquid Crystals, 744:1, 74-91, Synthesis, crystal structure, computational, and molecular docking studies of bis {1,1'-[1,3,5-Trimethyl-1,3-phenylenebis(methylene)]di-1H-piperidinium}tetrabromide tri hydrate ABSTRACT Recently synthesized crystal of Bis f1,1'-[1,3,5-Trimethyl-1,3-phenyle-nebis(methylene)]di-1H-piperidiniumgtetrabromide trihydrate (PD1Br) crystallizes in the monoclinic space group P2 1 /c. The piperidine ring as a whole adopted chair conformation. Hirshfeld surface technique is useful for determining molecular nature and visualizing intermolecular relations in crystal structures. The molecular configuration, frontier theory of orbitals, and thermodynamic character of the label molecule were examined via density functional theory (DFT) computations make use of the B3LYP method with the 6-311þþG (d,p) basis set. On the report of molecular docking investigation, the chemical binds efficiently to protein, resulting in a significant anticancer property. GRAPHICAL ABSTRACT
... The inhibiting potential of the BAgNPs toward the growth of bacteria was analyzed by disk diffusion assay against S. aureus (MTCC 1144), E. coli (MTCC 739), and P. aeruginosa (MTCC 741) bacterial strains. [38,39] Three culture inoculums of bacteria with 10 7 cfu mL À1 concentrations were spread on separate LB agar plates. On which the sterile paper disks (5 mm diameter) were placed. ...
The present study demonstrates green chemistry assisted synthesis of silver nanoparticles (B-AgNPs) in aqueous medium employing bark extract of Aegle marmelos L., their characterization and biological applications. B-AgNPs were synthesized at 70 °C with 0.005 M AgNO3 was reduced with 5.0 mL of bark extract for 20 min and monitored with UV-Vis spectrum. The size, charge, stability, and polydispersity index of B-AgNPs were determined using dynamic light scattering (DLS) and zeta potential analysis. Scanning electron microscope and high resolution transmission electron microscopy images showed that spherical-shaped BAgNPs were formed with average size of 20 nm along with a hydrodynamic diameter ranging from 5 to 100 nm in two subpopulations as evaluated by DLS analysis.Fourier transmission infrared spectrum ascertain the functional groups and purity while energy dispersive X-ray spectroscopy study confirms the elemental composition of BAgNP. B-AgNPs remarkably exhibit DNA cleavage activity against pUC19 and binding activity with CT-DNA. The growth inhibition potential of BAgNPs against Staphylococcus aureus, Escherichia Coli, and Pseudomonas aeruginosa bacterial strains was tested and they exhibited minimum inhibitory concentration value 10 μM against E. coli lower than the plant extract. DPPH assay in different concentrations of BAgNPs revealed the antioxidant potential between 41.3% and 90.2%.
... They play significant role in developing an understanding towards the processes such as biochemical, catalytic, hydrometallurgical, extraction of metal, activation, encapsulation and transportation [21][22][23]. They are found in many anticancer [24][25][26][27][28], antibacterial [26] and antimicrobial [28] activities. ...
... They play significant role in developing an understanding towards the processes such as biochemical, catalytic, hydrometallurgical, extraction of metal, activation, encapsulation and transportation [21][22][23]. They are found in many anticancer [24][25][26][27][28], antibacterial [26] and antimicrobial [28] activities. ...
Manganese(II) and cobalt(II) complexes were synthesized with [N4] tetradentate macrocyclic ligand using different metal salts i.e. MnCl2, Mn(NO3)2, CoCl2 and Co(NCS)2. The ligand was prepared by condensation of glyoxal and carbahydrazide. All these were characterized by elemental analysis, molar conductance measurements, magnetic moment, IR, mass, electronic and EPR spectral studies. Elemental analysis indicates that the complexes have composition MLX2 where (X = Cl–, NO3 –,NCS–). All the complexes were found to be non-electrolytic in nature so can be formulated as [MLX2]. Infrared spectra of metal complexes suggest that the ligand behaves as tetradentate. On the basis of magnetic moment, electronic and EPR spectral data, all the metal complexes were found to be high spin with octahedral geometry.
