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Abstract Background Clinical Practice Guidelines (CPGs) play an important role in clinical practice, and they require appropriate evaluation, especially in application. This study explores the application evaluation method of CPGs for Traditional Chinese Medicines (TCM). It uses the Analytic Hierarchy Process (AHP) and clinical cases to evaluate th...
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Background: Stroke is a severe and life-threatening disease, owns high rates of disability and mortality.[1] Stroke and ischemic heart disease, chronic obstructive pulmonary disease are the world’s three main killers.Ischemic strokes account for the vast majority of strokes.[2] Modern medicine has some advantages in treating ischemic stroke, but th...
Citations
... [13][14][15] Wen-Dan Decoction (WDD) is one of the ancient prescriptions widely used in the treatment of CHD in China. [16] Studies have found that WDD can lower blood lipids, improve blood rheology, reduce serum inflammatory response factors, and protect vascular endothelium. [17][18][19] This may be related to the regulation of fat cell lipolysis pathways, cytokine-cytokine receptor interaction pathways, fat digestion and absorption pathways. ...
Background:
Coronary heart disease (CHD) is a heart disease caused by myocardial ischemia, hypoxia or necrosis due to stenosis or occlusion of lumen caused by coronary atherosclerosis. It belongs to ischemic cardiomyopathy and is more common in clinic. Previous studies have shown that Wen-Dan Decoction (WDD) is safe and effective, but there is a lack of systematic reviews. The purpose of this study is to systematically study the efficacy of WDD in the treatment of patients with CHD.
Methods:
We will search the following databases: PubMed, EMBASE, Web of Science, Central, Chinese databases China Biomedical Literature, Wanfang Chinese digital periodical and conference database (Wanfang Database), China National Knowledge Infrastructure database, and VIP Chinese Science and Technique Journals Database (VIP) from inception to August 2021. All published randomized controlled trials related to this study will be included. The ongoing or unpublished trials will be searched from National Institutes of Health clinical registry Clinical Trials, International Clinical Trials Registry Platform and the Chinese clinical trial registration platform. Two researchers separately screened the literature and extracted data. The primary outcome is total effective rate. The RevMan V5.3 will be used to evaluate literature and data analysis synthesis.
Results:
This study will provide a reliable evidence-based basis for the clinical application of WDD in the treatment of patients with CHD.
Conclusion:
The effectiveness of WDD for CHD will be evaluated.
Unique inplasy number:
2021110001.
... The same syndrome of TCM could be affected by different pathological mechanisms in different diseases, and each kind of disease has its own course stage. [15] Therefore, the combination of disease and syndrome is of great significance for the establishment of standard quantitative diagnostic criteria for PSD, and opens an avenue for development of TCM. The establishment of a quantitative diagnosis model of TCM syndromes based on the combination of disease and syndrome can make the diagnosis of TCM syndromes more objective, and provide a basis for the clinical treatment and efficacy discrimination of diseases. ...
Background:
Post-stroke depression (PSD) is one of the most common stroke complications with high morbidity. Researchers have done much clinical research on Traditional Chinese Medicine (TCM) treatment, but very little research on diagnosis. Based on the thought of combination of disease and syndrome, this study will establish a unified and objective quantitative diagnosis model of TCM syndromes of PSD, so as to improve the clinical diagnosis and treatment of PSD.
Objective:
First: To establish a unified and objective quantitative diagnosis model of TCM syndromes in PSD under different disease courses, and identify the corresponding main, secondary, and concurrent symptoms, which are based on the weighting factor of each TCM symptom. Second: To find out the relationship between different stages of PSD and TCM syndromes. Clarify the main syndrome types of PSD under different stages of disease. Reveal the evolution and progression mechanism of TCM syndromes of PSD.
Methods and analysis:
This is a retrospective study of PSD TCM diagnosis. Three hundred patients who were hospitalized in the First Teaching Hospital of Tianjin University of TCM with complete cases from January 2014 to January 2019 are planned to be recruited. The study will mainly collect the diagnostic information from the cases, find the related indicators of TCM and Western medicine in PSD, and clarify the relationship between different disease stages and TCM syndromes. Finally, the PSD TCM syndrome quantitative diagnosis model will be established based on the operation principle of Back Propagation (BP) artificial neural network.
Conclusion:
To collect sufficient medical records and establish models to speed up the process of TCM diagnosis.
... TCM decoction refers to a method consisting of herbs with relatively specific processing methods and usage. The decoction is the main prescription of TCM, so it is necessary to make a detailed report on the TCM decoction [26,27]. For item 8-5 (S4-1 in the checklist of the RIGHT-TCM), it is recommended to describe the administration route and frequency of TCM decoction. ...
Nowadays, the number of traditional Chinese medicine (TCM) guidelines is constantly increasing, but its reporting quality is still disappointing. One of the main reasons is that there is a lack of suitable reporting standard to guide it. Low-quality reports impede the presentation of the guidelines’ content even if the guidelines are well projected and developed, thereby hindering the user’s integration and evaluation of guidelines and even misleading clinical decisions [1,2]. In response to this long-standing problem, the Reporting Items for practice Guidelines in HealThcare (RIGHT) Working Group has organized a group of TCM clinical experts, methodologists, and epidemiology, through a multi-staged development process, including systematic review, reporting quality evaluation and online Delphi expert consensus, developed the RIGHT Extension Statement for TCM (RIGHT-TCM). The RIGHT-TCM extends two sections of the RIGHT Statement, includes basic information and recommendations section. Seven strong recommendation sub-items were added on the basis of RIGHT Statement and formed the RIGHT-TCM finally. The group hopes that the RIGHT-TCM can assist TCM guideline developers in reporting guidelines, support journal editors and peer reviewers when considering TCM guideline reports, and help health care practitioners understand and implement a TCM guideline. This article will introduce its background, development, recommendations and explanation as follows.
Poria is an important medicine for inducing diuresis to drain dampness from the middle energizer. However, the specific effective components and the potential mechanism of Poria remain largely unknown. To identify the effective components and the mechanism of Poria water extract (PWE) to treat dampness stagnancy due to spleen deficiency syndrome (DSSD), a rat model of DSSD was established through weight-loaded forced swimming, intragastric ice-water stimulation, humid living environment, and alternate-day fasting for 21 days. After 14 days of treatment with PWE, the results indicated that PWE increased fecal moisture percentage, urine output, D-xylose level and weight; amylase, albumin, and total protein levels; and the swimming time of rats with DSSD to different extents. Eleven highly related components were screened out using the spectrum-effect relationship and LC-MS. Mechanistic studies revealed that PWE significantly increased the expression of serum motilin (MTL), gastrin (GAS), ADCY5/6, p-PKAα/β/γ cat, and phosphorylated cAMP-response element binding protein in the stomach, and AQP3 expression in the colon. Moreover, it decreased the levels of serum ADH, the expression of AQP3 and AQP4 in the stomach, AQP1 and AQP3 in the duodenum, and AQP4 in the colon. PWE induced diuresis to drain dampness in rats with DSSD. Eleven main effective components were identified in PWE. They exerted therapeutic effect by regulating the AC-cAMP-AQP signaling pathway in the stomach, MTL and GAS levels in the serum, AQP1 and AQP3 expression in the duodenum, and AQP3 and AQP4 expression in the colon.
