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Susceptibility of Pseudomonas aeruginosa isolates according to whether they were multidrug-resistant or not.
Source publication
Background
Multidrug-resistant (MDR) Pseudomonas aeruginosa is a frequent opportunistic pathogen that causes significant mortality in patients with non-cystic fibrosis bronchiectasis (NCFB). Although the quorum sensing (QS) system is a potential target for treatment, lasR mutants that present with a QS-deficient phenotype have been frequently repor...
Context in source publication
Context 1
... selected one isolate from a respiratory sample of each patient, and the susceptibility of P. aeruginosa isolates was summarized according to whether they were MDR or not ( Table 2). The QS phenotypes of signal molecules (3OC12-HSL and C4-HSL) and virulent factors (pyocyanin and protease) were compared between MDR and non-MDR isolates ( Figure 1). ...Similar publications
In recent years, traditional antibiotic efficacy has rapidly diminished due to the advent of multidrug‐resistant (MDR) bacteria which pose severe threats to human life and globalized healthcare. Currently, the development cycle of new antibiotics cannot match the ongoing MDR infection crisis. Therefore, novel strategies are required to resensitize...
Citations
Antimicrobial resistance (AMR) is a growing threat to public health, global food security and animal welfare. Despite efforts in antibiotic stewardship, AMR continues to rise worldwide. Anthropogenic activities, particularly intensive agriculture, play an integral role in the dissemination of AMR genes within natural microbial communities - which current antibiotic stewardship typically overlooks. In this review, we examine the impact of anthropogenically induced temperature fluctuations, increased soil salinity, soil fertility loss, and contaminants such as metals and pesticides on the de novo evolution and dissemination of AMR in the environment. These stressors can select for AMR - even in the absence of antibiotics - via mechanisms such as cross-resistance, co-resistance and co-regulation. Moreover, anthropogenic stressors can prime bacterial physiology against stress, potentially widening the window of opportunity for the de novo evolution of AMR. However, research to date is typically limited to the study of single isolated bacterial species - we lack data on how intensive agricultural practices drive AMR over evolutionary timescales in more complex microbial communities. Furthermore, a multidisciplinary approach to fighting AMR is urgently needed, as it is clear that the drivers of AMR extend far beyond the clinical environment.
