Fig 1 - available via license: Creative Commons Attribution 4.0 International
Content may be subject to copyright.
Survival rate of B. alexandrina snails infected with S. mansoni miracidia in control and treated groups with algae A. coffeaeformis and S. obtusus. No significant differences were found between all groups
Source publication
Schistosoma mansoni is the main factor of human schistosomiasis which is responsible for high rates of mortality. Recently, the use of alternative biological control agents has gained importance in disease control because the intensive use of molluscicides is very harmful to human health and poses risks to the environment. In the present work, the...
Context in source publication
Context 1
... of dried algal material of Amphora coffeaeformis and Scendesmus obtusus on the susceptibility of B. alexandrina snails to infection with S. mansoni miracidia Figure 1 shows that there is no significant difference in survival rate between all experimental groups. Generally, the infected snails previously exposed to different concentrations of both algae have a significant decrease in their infection rate compared to the control group (p < 0.05). ...
Similar publications
Background
Gastropods of the genus Biomphalaria (Family Planorbidae) are exploited as vectors by Schistosoma mansoni, the most common causative agent of human intestinal schistosomiasis. Using improved genomic resources, overviews of how Biomphalaria responds to S. mansoni and other metazoan parasites can provide unique insights into the reproducti...
The human telomerase reverse transcriptase (hTERT) is the catalytic sub-unit of the ribonuclear protein, telomerase. Together with telomerase RNA, the enzyme complex participates in the maintenance of telomeres at the proximal ends of chromosomes, adding species-specific repeats to the 3’end of the telomere. The regulation of hTERT is tightly linke...
Schistosomiasis, or also generally known as bilharzia or snail fever, is a parasitic disease that is caused by trematode flatworms of the genus Schistosoma. It is considered by the World Health Organisation as the second most prevalent parasitic disease after malaria and affects more than 230 million people in over 70 countries. People are infected...
Freshwater snails act as obligate intermediate hosts for trematode parasites that cause trematodiases threatening public and veterinary health, and biodiversity conservation. Therefore, interest has re-emerged in snails as a target for disease control, yet their ecology is poorly understood. We studied the relationship between physical and chemical...
Objective: To assess the molluscicidal effect of the eco-friendly green synthesized neem silver nanoparticles (neem-Ag NPs) against Biomphalaria alexandrina, the snail intermediate host for Schistosoma mansoni, and their cercaricidal potential.
Methods: Methanol extracts from neem fruits were used for green synthesis of neem-Ag NPs. The neem-Ag NPs...
Citations
... The present study showed that the hemolymph of Bulinus snails contains three types of hemocytes: granulocytes, hyalinocytes, and amoebocytes. This classification is following that reported by Mossalem et al. (2017), Bahgat et al. (2018), and Mansour et al. (2021), (2022. Granulocytes are the main cells engaged in snail defense (Barçante et al., 2012), thus, variations in their count upon facing parasitic infection are more likely to occur than variations in hyalinocytes' count (Oliveira et al., 2010). ...
Schistosomiasis is a snail-born, neglected tropical disease (NTD) caused by blood flukes (trematode worms) of the genusSchistosoma. It is the second most socioeconomically devastating parasitic disease after malaria. Urogenital schistosomiasis is caused by Schistosoma haematobium which is transmitted by snail intermediate host of the genus Bulinus. This genus is a model system for the study of polyploidy in animals. This study aims to investigate ploidy levels existing among the Bulinus species and their compatibility with S. haematobium. The specimens were collected from two governorates in Egypt. Chromosomal preparation was made from gonad tissue (ovotestis). This study found two ploidy levels (tetraploid, n = 36 and hexaploid, n = 54) of B. truncatus/tropicus complex in Egypt. Tetraploid B. truncatus was found in El-Beheira governorate while-unexpectedly and for the first time in Egypt, the hexaploid population was found in Giza governorate. This identification focused on shell morphology, chromosomal count, and spermatozoa of each species. Afterward, all species were exposed to S. haematobium miracidia where B. hexaploidus snails were the only refractory species. The histopathological study showed early destruction and abnormal development of S. haematobium in B. hexaploidus tissues. In addition, the hematological investigation showed increasing in the total hemocyte count, the formation of vacuoles, several pseudopodia, and more dense granules in the hemocytes of infected B. hexaploidus snails. In conclusion, there were two types of snails one was refractory and the other was susceptible.
Schistosomiasis is one of the most common waterborne parasite illnesses, it is a major public health issue in developing countries. The polymerase chain reaction (PCR) technique is used to find Schistosoma haematobium DNA in Bulinus truncatus , which could speed up the discovery of infections before cercariae are shed. DraI‐PCR detected S. haematobium infection at different infection intervals with bands at 300 bp in shedding snails 40 days after exposure and even on the first day after B. turancuts snails exposure to miracidia. Transmission electron microscopy showed the structure of sporocyst from 1 to 40 days post‐exposure and activated hemocytes in infected non‐shedding snails as well as sporocyst degradation. Flow cytometry was used to measure the percentage of Bax and TGF‐β1 positive stained cells that have been linked with infection progression. In conclusion, molecular tools and immune response play an important role in the strategy of controlling schistosomiasis through the early detection of larval stages in intermediate hosts toward certification of schistosomiasis elimination.
Research Highlights
DraI‐PCR allowed early detection of S. haematobium at 300 bp in B. truncatus snail.
Transmission electron microscopy showed the structure of S. haematobium sporocyst in snail and activated hemocytes in non‐shedding snail.
Bax protein that induced apoptotic changes and Transforming Growth Factor Beta1 level have been linked with parasite development.
