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In the present analytical study a rapid, robust and specific UPLC method has been developed and validated for Aliskiren hemifumarate and Hydrochlorothiazide in bulk and in combined tablet dosage form and it was applied to the dissolution study of Aliskiren hemifumarate and Hydrochlorthiazide. The separation was carried out on acquality UPLC HSS T3...
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The proposed work was accurate and precise stability indicating RP-HPLC method has been developed and validation of Ritonavir, in tablet dosage form. The separation was achieved on a Kromasil C18 (4.6×250mm, 5µ) column using a mixture of Methanol: water (60: 40% v/v) as the mobile phase at a flow rate of 1.0 mL/min and detected 217 nm. The retentio...
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Objective: The objective of this study was to formulate and optimize a mouth dissolving formulation of levosulpiride. Method: Levosulpiride mouth dissolving tablet having D2-dopamine receptor antagonistic activity were made by direct compression using microcrystalline cellulose, mannitol, povidone and a disintegrant sodium starch glycolate. Thus, f...
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Pharmaceutical formulations are experiencing a significant transformation as novel drug delivery techniques become increasingly available and effective. While there are many different types of medical dosage forms, each has its own limitations, such as tablet choking and painful parenteral dosages. Buccal drug delivery, which involves administering...
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A new, sensitive, precise, and accurate reversed-phase-high performance liquid chromatographic assay method for Valsartan and Sacubitril in combined tablet dosage form was developed and validated. Chromatographic separation was optimized by gradient HPLC on a C18 column [Inertsil ODS, 250 x 4.6 mm, 5µ] utilizing a mobile phase consisting of mixture...