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Structures of compounds 1-4.
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Two new lanostane triterpnenoids named endertiins A and B (1 and 2) together with two known compounds as ganodecalone A (3) and ergosterol (4) have been successfully isolated from the cultivated fruit bodies of the mushroom Humphreya endertii Stey (Ganodermataceae). Their structures were elucidated by a combination of HR-MS and 2 D NMR spectroscopi...
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... of compound 1 was also deduced by its NOESY spectrum. There were NOE correlation between H-24 and H-26 indicating the configuration of the double bond C 24-25 was trans. H-5 was found to be a-face since it had NOE correlation with H-28. From the above discussion, compound 1 was assigned to be (24E)-3,11-dioxo5a-lanosta-8,24-dien-26-al as shown in Fig. 1 and named endertiin ...
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Citations
Four natural products of Ganoderma lucidum triterpenoids were semi-synthesized for the first time and the active compound endertiin B was demonstrated to play an anti-breast cancer role through the PI3K-AKT pathway.
Breast cancer is the most prevalent type of cancer, the fifth leading cause of cancer-related deaths, and the second leading cause of cancer deaths among women globally. Recent research has provided increasing support for the significance of phytochemicals, both dietary and non-dietary, particularly triterpenoids, in the mitigation and management of breast cancer. Recent studies showed that triterpenoids are promising agents in the treatment and inhibition of breast cancer achieved through the implementation of several molecular modes of action on breast cancer cells. This review discusses recent innovations in plant triterpenoids and their underlying mechanisms of action in combating breast cancer within the timeframe spanning from 2017 to 2023. The present work is an overview of different plant triterpenoids with significant inhibition on proliferation, migration, apoptosis resistance, tumor angiogenesis, or metastasis in various breast cancer cells. The anticancer impact of triterpenoids may be attributed to their antiproliferative activity interfering with angiogenesis and differentiation, regulation of apoptosis, DNA polymerase inhibition, change in signal transductions, and impeding metastasis. The present review focuses on several targets, mechanisms, and pathways associated with pentacyclic triterpenoids, which are responsible for their anticancer effects. We could conclude that natural triterpenoids are considered promising agents to conquer breast cancer.
Graphical Abstract
The endophytic fungus Periconia sp. TJ403-rc01 (Dematiaceae) isolated from the leaves of Rosa chinensis Jacq. (Rosaceae) was cultivated on rice medium and chemically investigated, affording two new lanostane-type triterpenoids, namely pericinones A and B (1 and 2). Their structures were determined mainly by 1 D and 2 D NMR and HRESIMS data. Notably, it is the first report of lanostane-type triterpenoids from species of Periconia. Compounds 1 and 2 showed moderate anti-inflammatory activity against the NO production with IC50 values of 24.12 ± 0.73 and 11.38 ± 1.56 μM, respectively.
