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... The changes in TRH will affect the feedback loop between the hypothalamus, pituitary and the ovary leading to changes in ovulation and menstruation. Early stages of thyroid dysfunction (before symptoms are manifest) can lead to subtle changes in ovulation and endometrial receptivity, which then may have profound effects on fertility [3] . ...
Polycystic Ovary Syndrome (PCOS) exists commonly among women in the reproductive age with an incidence rate of 3-15%.The clinical manifestations of PCOS include oligomenorrhoea, infertility and obesity. There is significant overlap of symptoms between PCOS and hypercytokinemia. The aim of this study was to investigate the prevalence of hypercytokinemia in PCOS patients. Materials and Method: This was a cross-sectional study of clinically diagnosed 50 females with PCOS and another 50 age-matched females were studied as the control population. PCOS and Hypothyroidism were diagnosed by Ultrasound (US) and biochemical parameters IL6, TSH, T 3 and T 4. Results: The mean IL6, TSH, T 3 and T 4 were significantly higher in women with PCOS as compared to healthy women controls. Conclusion: PCOS is on the rise in hypothyroid patients. Identification of hypothyroidism may help us to treat and prevent fertility complications in PCOS females. Hypothyroidism needs to be early corrected in the management of infertility associated with PCOS which is of major concern these days.
