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... structure lined by single layer of cuboidal to low-columnar cells. They had high grade pleomorphic nucleolus, thick nuclear membrane and small to moderate amount of eosinophilic cytoplasm (Fig. 2). The stroma showed marked desmoplasia with interdigitating invasion of tumour cells. A small foci of in situ dysplasia was seen adjacent to the tumour (Fig. 3) Tumour involvement was present in the capsule, renal pelvis, perinephric fat, and all three interaortocaval lymph nodes. Immunohistochemical studies revealed that the tumour cells were positive for pancytokeratin, cytokeratin19 (CK19), and vimentin (Fig. 4). Based on these findings she was diagnosed to have collecting duct carcinoma ...
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Citations
Bellini duct carcinoma of kidney derives from collecting duct and is associated with an aggressive course and extremely poor prognosis.
Here, we report an interesting case of Collecting Duct Carcinoma (CDC) with Inferior Vena Cava (IVC) thrombus and large retroperitoneal
lymph nodes and diffuse desmoplastic reaction. The patient underwent left open radical nephrectomy with IVC thrombectomy and
regional lymphadenectomy. Based on morphological and immunohistochemical analysis, diagnosis of collecting duct (Bellini duct)
carcinoma was made. Presently, patient is on adjuvant chemotherapy with gemcitabine and cisplatin and under follow-up.
