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Stillbirth and neonatal mortality for trisomy 18 and trisomy 13
Source publication
Objectives To determine the prenatal detection rate of abnormality (fetal anomaly or growth restriction) in pregnancies complicated by fetal trisomies 21, 18 and 13 in an obstetric population managed without routine biochemical or sonographic screening tests and to assess the perinatal outcome of these pregnancies. Subjects and methods This was a r...
Context in source publication
Context 1
... major malformations were diagnosed in 25% (15 of 60) of babies born with trisomy 21 of which cardiac malformations were the most common (10 of 60 (16.7%)), followed by malformations of the gastrointestinal tract (four of 60 (6.6%)) and the urinary tract (one of 60 (1.7%)). For pregnancies complicated by trisomy 18 the stillbirth rate was 18.7% (three of 16) and 81.3% (13 of 16) of babies were born alive (Table 3). A further 18.7% (three of 16) died in the first 24 hours of life, and nine of the ten remaining babies were dead by 14 days of age (overall perinatal/neonatal mortality was 93.8% (15 of 16)). ...Similar publications
Fetal congenital heart disease (CHD) is often associated with chromosomal abnormalities. Our primary aim was to assess stillbirth and neonatal mortality rates for pregnancies complicated by trisomies 13, 18, and 21 in the presence of CHD, from a single tertiary referral center during 2000–2020 in a retrospective cohort study. The secondary aims wer...
Background:
Cell-free fetal DNA (cffDNA) has opened up new approaches for non-invasive prenatal testing (NIPT), and it is often used as the second-tier test for high-risk pregnant women in detecting trisomy (T) 21, T18, and T13 after serum biochemistry screening. This study aims to discuss the clinical performance of NIPT as an alternative first-t...
Although non-invasive prenatal testing (NIPT) is widely used to detect fetal abnormalities, the results of NIPT vary by population, and data for the screening efficiency of NIPT positive predictive value (PPV) from different populations is limited. Herein, we retrospectively analyzed the NIPT results in a large multicenter study involving 52,855 pr...
To examine characteristics and outcomes of T18 and T13 infants receiving intensive surgical and medical treatment compared to those receiving non-intensive treatment in NICUs.
Retrospective cohort of infants in the Children’s Hospitals National Consortium (CHNC) from 2010 to 2016 categorized into three groups by treatment received: surgical, intens...
High Sperm DNA fragmentation can cause decreased fertility & implantation rate or can cause Recurrent implantation failure and if fetus born then can lead to Genetic abnormality in the fetus such as Down Syndrome, Edward syndrome or Patau’s syndrome. The objective of the study is to combine the peripheral data of the patients to evaluate the safety...
