Figure 9 - available via license: Creative Commons Attribution 4.0 International
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Spinal cord transverse section (lumbar anterior horn) in benfotaimine or hesperidin with paraquat treated rats shows similar picture to that of the control with few vacuolation (v), degenerated neurons (e) and dilated congested capillaries (*) H & E (×400).
Contexts in source publication
Context 1
... and eosin-stained sections showed near normal appearance of the control group sections with few vacuolation, degenerated neurons and dilated congested capillaries (Figure 9). ...
Citations
... In a comparable manner, thalidomide and minocycline decreased paclitaxel-induced neuropathic pain in rats through TNF-α and IL1-β suppression [56]. Moreover, hesperidin reduced the level of serum neurofilament in induced spinal cord injury in a rat model [57]. The level of NGF was consumed because of nerve injury in many studies [37,40,58]. ...
Neurological injury is a crucial problem that interferes with the therapeutic use of vinca alkaloids as well as the quality of patient life. This study was conducted to assess the impact of using loratadine or diosmin/hesperidin on neuropathy induced by vinca alkaloids. Patients were randomized into one of three groups as follows: group 1 was the control group, group 2 received 450 mg diosmin and 50 mg hesperidin combination orally twice daily, and group 3 received loratadine 10 mg orally once daily. Subjective scores (numeric pain rating scale, douleur neuropathique 4, and functional assessment of cancer therapy/gynecologic oncology group–neurotoxicity (FACT/GOG-Ntx) scores), neuroinflammation biomarkers, adverse drug effects, quality of life, and response to chemotherapy were compared among the three groups. Both diosmin/hesperidin and loratadine improved the results of the neurotoxicity subscale in the FACT/GOG-Ntx score (p < 0.001, p < 0.01 respectively) and ameliorated the upsurge in neuroinflammation serum biomarkers. They also reduced the incidence and timing of paresthesia (p = 0.001 and p < 0.001, respectively) and dysuria occurrence (p = 0.042). Both loratadine and diosmin/hesperidin attenuated the intensity of acute neuropathy triggered by vinca alkaloids. Furthermore, they did not increase the frequency of adverse effects or interfere with the treatment response.
