Figure - available from: Journal of Ophthalmology
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Slit-lamp photograph of the filtering bleb. (a) Bleb photograph taken 4 years after trabeculectomy with AMT showed a bleb with medium height, 4-clock hour extent, and mild vascularity. Intraocular pressure (IOP) was 13 mmHg without medication. (b) Bleb photograph taken 5 years after trabeculectomy without AMT showed medium height, 3-clock hour extent, and avascular cystic bleb. IOP was 16 mmHg without medication.
Source publication
Purpose:
The aim is to evaluate the effect of amniotic membrane transplantation (AMT) on trabeculectomy with mitomycin C in patients with pseudoexfoliation glaucoma (PXG).
Methods:
This retrospective cohort study included 85 eyes of PXG who underwent trabeculectomy with or without AMT (52/33 eyes in the AMT/control group). Surgical success was d...
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Purpose
To evaluate the effectiveness of cryopreserved human amniotic membrane transplantation (hAMT) in patients with infectious ulcerative keratitis.
Methods
A retrospective cohort study based on medical records of patients who underwent hAMT procedure over a 2-year period (2020–2021) was conducted at Ege University Hospital, Turkey. Cryopreserv...
Citations
... Trabeculectomy with amniotic membrane transplantation (AMT) above or under the scleral flap had a high success rate and fewer complications [10][11][12]. We previously evaluated the effect of AMT on trabeculectomy and found that it was a safe and effective procedure for intraocular pressure (IOP) reduction in patients with primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma [13,14]. Furthermore, the incidence of avascular blebs was significantly lower in the AMT group than in the control group. ...
Introduction:
Little has been known about the intrableb structures associated with bleb function after trabeculectomy with amniotic membrane transplantation (AMT). The aim of this study is to analyze the characteristics of intrableb structures using anterior segment optical coherence tomography (AS-OCT) after trabeculectomy with AMT.
Methods:
A total of 68 eyes of 68 patients with primary open-angle glaucoma who underwent trabeculectomy with AMT were included. Surgical success was defined as intraocular pressure (IOP) ≤ 18 mmHg and IOP reduction of ≥ 20% without medication on AS-OCT examination. Intrableb parameters, including bleb height, bleb wall thickness, striping layer thickness, bleb wall reflectivity, fluid-filled space score, fluid-filled space height, and microcyst formation were evaluated using AS-OCT. Logistic regression analysis was performed to determine factors associated with IOP control.
Results:
Of the 68 eyes, 56 eyes were assigned to the success group and 12 eyes to the failure group. In the success group, bleb height (P = 0.009), bleb wall thickness (P = 0.001), striping layer thickness (P = 0.001), fluid-filled space score (P = 0.001), and frequency of microcyst formation (P = 0.001) were greater than those in the failure group. Bleb wall reflectivity was higher in the failure group than in the success group (P < 0.001). In the univariate logistic regression analysis, previous cataract surgery was significantly associated with surgical failure (odds ratio = 5.769, P = 0.032).
Conclusion:
A posteriorly extending fluid-filled space, tall bleb with low reflectivity, and thick striping layer were characteristics of successful filtering blebs after trabeculectomy with AMT.
