Figure - available from: Dermatologic Therapy
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Skin biopsy from right side of the face (A) before treatment (H&E ×200), (B) after treatment (2 weeks after the last session) showed improvement of epidermal atrophy with increase in its thickness, increase in rete ridges (H&E ×200), (C) before treatment (H&E ×400), (D) after treatment (2 weeks after the last session) showed increase in thickness of collagen bundles (H&E ×400)
Source publication
Background:
Many modalities are used for treatment of facial wrinkles, such as micro-needling that enhances collagen production, and platelet-rich plasma (PRP) which contains concentrated levels of growth factors. The human amniotic membrane isolated from the placentae of donors (during elective cesarean sections) has high levels of growth factors...
Similar publications
Background: Many modalities are used for treatment of facial wrinkles, such as microneedling
that enhances collagen production, and platelet-rich plasma (PRP) which
contains concentrated levels of growth factors. The human amniotic membrane isolated
from the placentae of donors (during elective cesarean sections) has high levels of
growth factors t...
Citations
... The AM markedly reduces the levels of pain and discomfort experienced by the patient when used as a biological dressing and has anti-in ammatory, anti-scarring and anti-angiogenic effects. Recently, it was used in rejuvenation , treatment of resistant ulcers, psoriasis with variable degrees of success (23,24) . ...
Background
Striae distensae (SD), often referred to as stretch marks, are common linear lesions seen in individuals of all ages. Many treatment choices are available, not yet satisfactory. Amniotic fluid contains many growth factors which can be helpful in treatment of stretch marks.
Aim of the work
was to assess the efficacy and safety of irradiated amniotic collagen matrix with micro-needling in treatment of stretch marks.
Patients and methods
This was a prospective, right-left comparative study carried out on 40 patients presenting with striae. Every patient received 6 sessions every two weeks, for the right side we used micro-needling associated with application of irradiated amniotic collagen matrix, for the left side we used micro-needling, the patients were followed up for 3 months. Skin biopsies were taken before and after treatment, stained with Masson trichrome and Orcein stains to confirm clinical response.
Results
In both sides, there was significant improvement after treatment and there was significant difference with better results in the right side than the left side as regarding degree of improvement, percent of improvement and start of response.
Conclusion
This method was safe, effective, and good tolerated office techniques with minimal side effects for treatment of stretch marks.
... An approach known as Subcision was introduced as a minimally invasive technique to treat scars, involving the use of extremely fine needles to disrupt dermal collagen and stimulate dermal remodeling and skin resurfacing [29,30]. The efficacy of the microneedling-delivered irradiated amniotic collagen matrix (IACM) compared to platelet-rich plasma (PRP) in facial rejuvenation was investigated [31]. The result showed that both approaches demonstrated effectiveness and safety in treating skin aging. ...
Collagen, the most abundant protein in our bodies, plays a crucial role in maintaining the structural integrity of various tissues and organs. Beyond its involvement in skin elasticity and joint health, emerging research suggests that collagen may significantly impact the treatment of complex diseases, particularly those associated with tissue damage and inflammation. The versatile functions of collagen, including skin regeneration, improving joint health, and increasing bone strength, make it potentially useful in treating different diseases. To the best of my knowledge, the strategy of using collagen to treat comorbid diseases has not been widely studied. This paper aims to explore the potential of collagen in treating comorbid diseases, including rheumatoid arthritis, osteoarthritis, osteoporosis, psoriatic arthritis, sarcopenia, gastroesophageal reflux, periodontitis, skin aging, and diabetes mellitus. Collagen-based therapies have shown promise in managing comorbidities due to their versatile properties. The multifaceted nature of collagen positions it as a promising candidate for treating complex diseases and addressing comorbid conditions. Its roles in wound healing, musculoskeletal disorders, cardiovascular health, and gastrointestinal conditions highlight the diverse therapeutic applications of collagen in the context of comorbidity management.
