Fig 5 - uploaded by Fawzi Kadi
Content may be subject to copyright.
Skeletal muscle fiber (a) cross-sectional area (CSA) and (b) satellite cell (SC) content before and after 12 weeks of resistancetype exercise training in 51 older (71±6 years) subjects. c Linear regression showing the relation between the change in type II muscle fiber SC content and the change in muscle fiber CSA following the 12-week training program. Data represent means ±SD. Asterisk: significantly different when compared with type I muscle fibers (P<0.001). Number sign: significantly different when compared with values before training (P<0.05)
Contexts in source publication
Context 1
... response to 12 weeks of resistance-type exercise training, type II muscle fiber size had increased by 20 ±21 % (Fig. 5a). The latter was significantly greater than the 9±22 % increase in type I muscle fiber size (P<0.001 for "time×fiber type" interaction). A significant "time×fiber type" interaction (P<0.001) showed that the increase in type II muscle fiber size was accompa- nied by an increase in type II muscle fiber myonuclear content (from 3.0±0.9 to ...
Context 2
... a significant "time×fiber type" interaction was observed. In contrast to the type I muscle fibers, type II muscle fibers showed a substantial increase in satellite cell content from 0.049±0.018 satel- lite cells per fiber at baseline to 0.074±0.032 satellite cells per fiber following 12 weeks of resistance-type exercise training (P<0.001; Fig. 5b). In accordance, type II muscle fiber satellite cell content significantly in- creased when expressed as the number of satellite cells relative to the total number of myonuclei (from 1.7±0.8 % to 2.2±1.0 %; P=0.001), as well as the number of satellite cells per square millimeter of muscle fiber area (from 9.6±3.9 to 12.0±5.3 satellite ...
Context 3
... cells per square millimeter; P=0.003). No such changes were observed in type I muscle fibers. Whereas at baseline, both muscle fiber size and muscle fiber satellite cell content were significantly lower in type II vs. type I muscle fibers, these differences were no longer apparent after 3 months of supervised resistance-type exercise training (Fig. ...
Context 4
... Type II: open circles/dashed line. Lines represent the fitted linear regression. Pearson correlation coefficients: (a) r=−0.033 (type I; P=0.682) and r=−0.56 (type II; P<0.001); (b) r=−0.109 (type I; P=0.184) and r=−0.57 (type II; P<0.001) (total R=0.73): (1) change in type II muscle fiber satellite cell content (standardized B=0.44, P=0.001; Fig. 5c), (2) change in type II muscle fiber myonuclear content (standardized B=0.44, P=0.004), and (3) baseline myonuclear content (standardized B=0.30, P=0.030). See Online Resource 1 for regression plots of all three ...
Context 5
... changes in muscle fiber satellite cell content and muscle fiber size, a subset of 51 elderly subjects (71±6 years) were subjected to a supervised resistance-type exercise training program. After 12 weeks of resistance-type ex- ercise training, we observed a type II muscle fiber- specific increase in satellite cell content and myonuclear content (Fig. 5). Even at a more advanced age, skeletal muscle tissue can still induce satellite cell proliferation and allows the subsequent incorporation of their differ- entiated progeny as newly formed myonuclei. This likely allowed the substantial 20 % increase in type II muscle fiber size following 12 weeks of training. Interestingly, a modest 9 ...
Similar publications
Skeletal muscle tissue regeneration requires quiescent satellite cell activation, proliferation, and differentiation. Regenerative capacity of satellite cells can be studied in vitro by differentiating under low‐serum conditions (2% to 5%) to form multinucleated myotubes. Myotubes are fixed and stained, and indices of differentiation are quantified...
