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The present study deals with the antioxidant activity assays one plant extract, Premna tomentosa, a plant having many medicinal values, such as anti-inflammatory, hepatoprotective and antidoarrhial etc. It was observed that in all the three types of assays, namely, FRAP, DPPH and ABTS, the plant extract indicated good antioxidant activity. The anti...
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Objectives:
Sepsis is a clinical illness with a high rate of mortality all over the world. Oxidative stress is considered the main phenomenon that occurs in sepsis. Rosa damascena Mill. is an ancient herbal plant with high pharmacological activities.
Materials and methods:
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The current study was carried out to assess the effect of the crude methanolic extract of Aerva javanica for hepatoprotective and nephroprotective assessment along with their antioxidant potential against 2,2-azinobis(3-ethylenbenzthiazolin)-6sulfonic acid (ABTS) and 2,2diphenyle-1-picrylhyzyl Original Research Article Wisal et al.; AJBGMB, 4(2): 1...
Rosmarinus officinalis L. is a widely known species for its medicinal uses, that is also used as raw material for the food and cosmetic industry. The aim of the present study was to offer a novel perspective on the medicinal product originating from this species and to test its hepatoprotective activity. The tested sample consisted in a tincture ob...
The present study deals with the antioxidant activity assays one plant extract, Premna tomentosa, a plant having many medicinal values, such as anti-inflammatory, hepatoprotective and antidoarrhial etc. It was observed that in all the three types of assays, namely, FRAP, DPPH and ABTS, the plant extract indicated good antioxidant activity. The anti...
Carissa spinarum Linn. has been utilized both in the food industry and as a traditional medicine for various ailments, while the responsible chemical components and action mechanisms of its antioxidative and hepatoprotective activities remain unclear. In this work, at least 17 quinic acid derivatives as potential ligands for the superoxide dismutas...
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Objective: There is an urgent need to prove the authenticity of Ayurvedic medicines in the light of modern scientific knowledge. Methods: The present study deals with the gas chromatography-mass spectrometry (GC-MS) analysis of one herbal oil, Kunthalakanti Thailam, to understand the molecules present there in. Kunthalakanti Thailam was bought from a standard Ayurvedic vendor from Chennai. It was processed and GC-MS analysis was done by standard procedures. Results: The GC-MS report indicated the presence of mostly fatty acids and their esters which have potent antioxidant and antiallerg ic properties such as N-Hexadecanoic acid, 2-Methyl-3-93-methyl-but-2-enyl)-enyl)-oxetane, 3, 7-decadien-2-one, and 10-(3,3-dimethoxyloxiran dimethyl-, (E, E)-, +/- which have medicinal activities which help in keeping the homeostasis of the scalp and maintain good health to hair follicles and hair. Some important biomolecules have medicinal properties supporting the validity of skin treatment with this oil. Conclusions: The presence of these biomolecules having medicinal properties supports the validity of Kunthalakanti Thailam as skin and hair health treatment.
Introduction: The present study deals with the gas chromatography–mass spectrometry (GC–MS) analysis of an Ayurvedic oil Triphaladi Thailam, which is used to treat spilt hair, headache, sinusitis, and rhinitis and also for diseases related to neck, eyes, ear, and throat and to understand the molecular roles of this medicine. Methods: Triphaladi Thailam was bought from a standard Ayurvedic vendor at Chennai and subjected to GC–MS analysis by standard procedures. The medicinal roles of the biomolecules indicated in the GC–MS profile were screened for their various medicinal roles using Dr. Duke’s phytochemical and ethnobotanical data and other data. Results: GC–MS profile of the Triphala Rasayana indicated the presence of important biomolecules such as 2-[4-methyl-6-(2,6,6-trimethylcyclohex-1-enyl)hexa-1,3,5-, á-Sitosterol, 1-Monolinoleoylglycerol trimethylsilyl ether, 1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one, and oleic acid. Conclusions: It is concluded that Triphala, which an age-old multipurpose folklore medicine does have a scientific efficacy. Further research is required for a better understanding of the medicinal roles of Triphaladi Thailam.
KEY WORDS: 1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one and oleic acid, 1-Monolinoleoylglycerol trimethylsilyl ether, 2-[4-methyl-6-(2,6,6-trimethylcyclohex-1-enyl)hexa-1,3,5-, á-Sitosterol, Gas chromatography–mass spectrometry, Triphaladi Thailam
Objective: The present study deals with the gas chromatography–mass spectrometry (GC–MS) analysis of an anti-obesity Ayurvedic medicine, Lohasava. Methods: Lohasava was bought from a standard Ayurvedic vendor at Chennai and subjected to GC–MS analysis by standard procedures. The medicinal roles of the biomolecules indicated in the GC–MS profile were screened for their various medicinal roles using Dr. Duke’s phytochemical and ethno-botanical data and other data. Results: The GC–MS profile of Lohasava indicated the presence of important biomolecules such as butanoic acid, 3-hydroxy-, ethyl ester, phenylethyl alcohol, ethyl hydrogen succinate, thymol, 4-hydroxy-2-methylacetophenone, hydrocinnamic acid, 2,6-dimethoxyphenyl-beta-phenylpropionate, bisphenol C, benzeneethanamine, 2,5-dimethoxy-alpha.,4-dimethyl-and piperine. Conclusions: It is concluded that Lohasava does have a scientific efficacy toward its claimed role as a medicine in Ayurveda. Further research is required for a better understanding of the medicinal roles of Lohasava.
KEY WORDS: 3-hydroxy-, ethyl ester, 4-Hydroxy-2-methylacetophenone, Bisphenol C, Butanoic acid, Ethyl hydrogen succinate, Gas chromatography–mass spectrometry, Hydrocinnamic acid, Lohasava, Phenylethyl alcohol, Piperine, Thymol
Introduction: The present work deals with the gas chromatography–mass spectrometry (GC–MS) analysis of Ksheerabala Thailam which is an Ayurvedic oil used for the treatment of Vata disorders such as neuromuscular pains, sciatica, spondylitis, paralysis, myalgia, for nerve regeneration, cataract, earache, and headache. Materials and Methods: Ksheerabala Thailam was bought from a standard Ayurvedic vendor at Chennai and subjected to GC–MS analysis by standard procedures. The medicinal roles of the biomolecules indicated in the GC–MS profile were screened for their various medicinal roles using Dr. Duke’s phytochemical and ethnobotanical data and other data. Results: GC–MS profile of the Ksheerabala Thailam indicated the presence of important biomolecules such as n-Hexadecanoic acid, 15-Hydroxypentadecanoic acid, Hexadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, (3-Fluorophenyl)carbamic acid, 2-isopropyl-5-methylphenyl ester, Hexadecanoic acid, 1-(hydroxymethyl)-1,2-ethanediyl ester, Hexadecanoic acid, 2-(octadecyloxy)ethyl ester,.gamma.-Tocopherol, and .gamma.-Sitosterol; these molecules do have medicinal roles which relate to that of Ksheerabala Thailam. Conclusions: It is concluded that Ksheerabala Thailam, which is an important Ayurvedic medicine, does contain some very important molecules showing its efficacy. Further research is required for a better understanding of the medicinal roles of Ksheerabala Thailam.
KEY WORDS: (3-Fluorophenyl)carbamic acid, 15-Hydroxypentadecanoic acid, 2-Isopropyl-5-methylphenyl ester.,gamma.-Tocopherol and .gamma.-Sitosterol, Gas chromatography–mass spectrometry, Hexadecanoic acid, 1-(hydroxymethyl)-1,2-ethanediyl ester, Hexadecanoic acid, 2-(octadecyloxy)ethyl ester, Hexadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, Ksheerabala thailam, n-Hexadecanoic acid
Introduction: The present work deals with the gas chromatography (GC)–mass spectrometry (MS) analysis of Drakshadi Kashayam, which is used in the treatment of Panduroga (anemia), jaundice, and diseases caused due to imbalance in Pitta (bile) consistency. Methods: Drakshadi Kashayam was bought from a standard Ayurvedic vendor at Chennai and subjected to GC–MS analysis by standard procedures. The medicinal roles of the biomolecules indicated in the GC–MS profile were screened for their various medicinal roles using Dr. Duke’s phytochemical and ethnobotanical data and other data. Results: GC–MS profile of Drakshadi Kashayam indicated the presence of important biomolecules such as carbonic acid, pentyl phenyl ester, bisphenol C, histamine, N-benzoyl-2-cyano-, o-Methoxy-.alpha.-phenethylamine, benzenethanamine, 3,4-dimethoxy-.alpha.-methyl-, cis-Z-.alpha.-Bisabolene epoxide, and 1,3-Dimethoxy-5-(1-methyl-heptyl)-benzene which have medicinal roles supporting the efficacy of Drakshadi Kashayam as a liver tonic. Conclusions: It is concluded that Drakshadi Kashayam, which is an important Ayurvedic medicine, does contain some very important molecules showing its efficacy. Further research is required for a better understanding of the medicinal roles of this medicine.
KEY WORDS: 3,4-dimethoxy-.alpha.-methyl-, Benzenethanamine, Bisphenol C, Carbonic acid, Drakshadi Kashayam, Gas chromatography–mass spectrometry, Histamine, N-benzoyl-2-cyano-, o-Methoxy-.alpha.-phenethylamine, Pentyl phenyl ester
Objective: Anuthailam, an Ayurvedic oil used for the treatment of diseases related to the brain, nose, sinus, eyes, head, neck, shoulders, and arms. Anuthailam is subjected to Gas chromatography–mass spectrometry (GC-MS) analysis to understand the molecules present therein. Materials and Methods: Anuthailam was bought from a standard Ayurvedic vendor at Chennai and subjected to GC-MS analysis by the standard procedures. The medicinal roles of the biomolecules indicated in the GC-MS profile were screened for their various medicinal roles using Dr. Duke’s Phytochemical and ethno-botanical data and other data. Results: GC-MS profile of the Anuthailam indicated the presence of important biomolecules such as 15-Hydroxypentadecanoic acid, hexadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, trans-13-Octadecenoic acid, 9-Octadecenoic acid (Z)-, 2-hydroxy-1-(hydroxymethyl)ethyl ester, 1-Heptatriacotanol.,gamma.-Tocopherol, (3-Fluorophenyl)carbamic acid, 2-isopropyl-5-methylphenyl ester, Stigmasterol, Hexadecanoic acid, 1-(hydroxymethyl)-1,2-ethanediyl ester, etc. Conclusions: It is concluded that Anuthailam, does have a scientific efficacy toward its claimed role as a medicine in Ayurveda. Further research is required for a better understanding of the medicinal roles of Anuthailam.
KEY WORDS: 1-(hydroxymethyl)-1,2-ethanediyl ester, 15-Hydroxypentadecanoic acid, 1-Heptatriacotanol, 2-hydroxy-1-(hydroxymethyl)ethyl ester, AnuThailam, gamma –Tocopherol, Gas chromatography–mass spectrometry, Hexadecanoic acid, Hexadecanoic acid, Stigmasterol, trans-13-Octadecenoic acid
Ayurvedic and other traditional forms of medicines require standardization to bring them at par with modern molecular medicine. The present study is to use thin layer chromatographic technique to understand the presence and variation of four important secondary metabolites namely, steroids, terpenoids, flavoniods and alkaloids in the Ayurvedic preparation, Triphala churna and its constituent ingredients, namely, Terminalia bellerica, terminalia chebula and Embelica officinalis. The TLC profiles of steroids, terpenoids, flavonoids and alkaloids indicated different behaviour for only rinds, only seeds, their respective mixtures, whole fruits separately and their mixtures. The results were compared with standards of each metabolite and also with market samples. It was observed that alkaloids were almost similar in all the samples indicating their predominance in Triphala ingredients as well as those of mixtures. Embelica officinalis was having more dominating and masking effect over the other two constituents for all the four metabolites studied. It was also clear that most of the market samples indicated the presence of whole fruits as their raw materials instead of the rinds alone, which needs to be addressed. From the study it is clear that this methodology can be used as a cheap tool to estimate the presence of the constituents in each sample and suggest this easy method for quality analysis of the samples before they come to market.
KEY WORDS: TLC, Triphala churna, Terminalia bellerica, Terminalia chebula, Embelica officinalis, Rf, standardization, Prednisolone, Quercetine, Caffine, Retinol
