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Show dot blot analysis of flow cytometry data of CD4/CD8 of two cases revealed. (a) A case with T-helper (16%) (768 cell/µl) and T-cytotoxic (10%) (480 cell/µl) with low absolute count; (b) A case with T-helper (42.9%) (4804.8 cell/µl) and T-cytotoxic (23.6%) (2643.2 cell/µl) with high absolute count.
Source publication
Background: Tailoring therapy is the target in the management of any cancer; if factors which can predict response to treatment are identified, we can individualize treatment. Locally advanced rectal cancer studies reported that tumor microenvironment and host immune response played roles in sensitivity to chemoradiotherapy (CRT) by proving that bo...
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At diagnosis, tumor-infiltrating lymphocytes (TILs) are prognostic in epithelial ovarian cancer (EOC). We recently demonstrated that neoadjuvant chemotherapy (NACT) significantly increased stromal TILs. Here, we investigated the impact of NACT on immune subpopulations with a particular focus on the balance of immune-reactive to tolerant...
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To investigate the relationship between tumor deposits (TDs) with the clinicopathological characteristics tumor-infiltrating lymphocytes (TILs) and prognosis of gastric cancer. Further analysis was done on the relationship between the number and maximum diameter of TDs with the clinicopathological characteristics and prognosis of gastric...
Citations
... Although several studies have concluded that the NLR is a prognostic indicator, there is limited data available on whether the ALC has prognostic value in potentially curable gastric cancer. Recent studies have shown that ALC is significantly associated with tumor-infiltrating lymphocytes (TILs) and mortality [15][16][17]. In patients with stage I-III triple-negative breast cancer, higher post-diagnosis peripheral ALCs predicted prolonged survival [15]. ...
... In patients with stage I-III triple-negative breast cancer, higher post-diagnosis peripheral ALCs predicted prolonged survival [15]. Furthermore, there was a direct positive correlation between TILs and ALCs during neoadjuvant chemotherapy or chemoradiotherapy [15,16]. In patients with relatively early-stage gastric cancer after gastrectomy, preoperative peripheral ALCs predicted postoperative survival [18]. ...
... In a previous study, an increased number of TILs in patients with triple-negative breast cancer was found to be directly correlated with increased peripheral lymphocyte counts during neoadjuvant chemotherapy [15]. Additionally, elevated peripheral lymphocyte counts in patients with rectal cancer were significantly correlated with high tissue levels of CD4+ and, CD8+ T cells [16]. As such, peripheral lymphocyte counts may also be associated with TILs in patients with gastric cancer, and may also predict immunological responses to cancer. ...
Background/aims:
Lymphocytes are an important component of the cell-mediated immune system. As lymphopenia is reportedly associated with poor prognoses in patients with various cancers, we investigated this notion in patients who underwent curative gastrectomy.
Methods:
We retrospectively analyzed the association between absolute lymphocyte count (ALC) and prognosis in patients with stage I-III gastric cancer who underwent curative surgical resection. Ever lymphopenic patients were defined as those with ALCs < 1,000/μL at any time post-diagnosis except within 30 days post-surgery. Adjusted multivariable regression models were used to evaluate the associations between lymphopenia and overall mortality, gastric cancer-specific mortality, and disease-free survival.
Results:
We investigated 1,222 patients diagnosed between January 2011 and December 2015. Fifty-six patients (4.6%) were lymphopenic at diagnosis and nearly one-quarter (24.8%) were ever lymphopenic with a mean minimum ALC of 640/μL. Older age (odds ratio [OR], 1.02) and higher stage (stage III vs. I; OR, 3.01) were positively associated with ever lymphopenia. On multivariable analysis, ever lymphopenia predicted higher overall mortality (hazard ratio [HR], 1.83; p = 0.008), higher gastric cancer-specific mortality (HR, 1.58; p = 0.048), and shorter disease-free survival (HR, 1.83; p = 0.006). The 5-year gastric cancer-specific mortality rates for ever- and never lymphopenic patients were 10.9% and 3.7%, respectively; their 5-year cumulative recurrence rates were 15.1% and 4.6%, respectively.
Conclusions:
This study demonstrate that ever lymphopenia is independent prognostic factor for overall mortality and recurrence in patients with potentially curable gastric cancer; hence, ALCs may be a biomarker for predicting the prognoses of patients with stage I-III gastric cancer who had curative gastrectomy.
... These findings may be explained by the concept that tumor microenvironment is an important factor that affects the response of the tumor to radiotherapy, and as part of the microenvironment peripheral blood lymphocytes count and ratio have same effect and can be an available simple and cheap predictive factor of response of locally advanced rectal cancer to neoadjuvant therapy [33,40]. Another explanation is the potential role of circulating T lymphocytes in predicting the response to nCRT and enhancing host immunological response [33,38,40]. ...
... These findings may be explained by the concept that tumor microenvironment is an important factor that affects the response of the tumor to radiotherapy, and as part of the microenvironment peripheral blood lymphocytes count and ratio have same effect and can be an available simple and cheap predictive factor of response of locally advanced rectal cancer to neoadjuvant therapy [33,40]. Another explanation is the potential role of circulating T lymphocytes in predicting the response to nCRT and enhancing host immunological response [33,38,40]. ...
... There is no model to predict this response until now. However, this model is important for future planning of management of LARC [17,18,33] . ...
... These findings may be explained by the concept that tumor microenvironment is an important factor that affects the response of the tumor to radiotherapy, and as part of the microenvironment peripheral blood lymphocytes count and ratio have same effect and can be an available simple and cheap predictive factor of response of locally advanced rectal cancer to neoadjuvant therapy [33,40] . Another explanation is the potential role of circulating T lymphocytes in predicting the response to nCRT and enhancing host immunological response [33,38,40] . ...
... These findings may be explained by the concept that tumor microenvironment is an important factor that affects the response of the tumor to radiotherapy, and as part of the microenvironment peripheral blood lymphocytes count and ratio have same effect and can be an available simple and cheap predictive factor of response of locally advanced rectal cancer to neoadjuvant therapy [33,40] . Another explanation is the potential role of circulating T lymphocytes in predicting the response to nCRT and enhancing host immunological response [33,38,40] . ...
