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Sex and age distribution of patients and infective organisms in jaundice caused by gram-negative bacterial infections. Data compiled from references 5-13 and 17-21.
Source publication
A variety of infectious diseases may produce jaundice or other biochemical abnormalities, even though the liver is not the primary site of infection.1–3 Despite the often serious nature of the infection or underlying disease process, the hepatic aspects are generally not life-threatening. However, the assorted liver aspects can mimic extrahepatic o...
Contexts in source publication
Context 1
... cause of jaundice in newborns. 2 For example, in one study of icteric neonates that excluded cases of hemolytic jaundice from fetomaternal blood incompatibility, jaundice of sepsis accounted for 25 of 76 cases. 7 Affected patients are usually male, under 3 months of age; the most common cause is urinary tract infection (UTI) with E. coli (Fig. 1). It is characterized by conjugated hyperbilirubinemia and slight to moderate increases in SAP and transaminase levels. Indeed, jaundice may be the only clinical sign of infection, as fever may not be present. 5,6.11 Rapid identification of the infective agent and appropriate antibiotic therapy usually leads to a complete ...
Context 2
... involvement of the liver is limited primarily to the bile duct epithelial cells with marked enlargement of the cells (i.e., cytomegalo-) by both intranuclear and cytoplasmic inclusion bodies. The intranuclear inclusion, when fully developed, consists of a large smooth eosinophilic body separated from the marginated chromatin by a clear halo (Fig. 10). Periodic acid- Schiff-positive granules may greatly distend the cytoplasm of the bile duct cells. Portal areas may display marked infiltration by lymphocytes, occasionally producing lymphoid aggregates or ger- minal centers.IZ3-IZ5 Less frequently, focal (and rarely) massive necrosis and bile stasis may be present. Several other viral ...
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Citations
Bile is a solution of organic and inorganic compounds in water. It is produced by hepatocytes and secreted into the bile canaliculi (canalicular bile). It is then modified as it passes through intrahepatic bile ductules and ducts (ductular bile). Most of the bile entering the extrahepatic biliary tree enters the gallbladder, where it is concentrated and stored between periods of digestion (gallbladder bile). Finally, meals stimulate gallbladder emptying which projects bile through the common bile duct into the duodenum, where bile facilitates digestion.
