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Primary squamous cell carcinoma of the endometrium is exceedingly rare. We report a case of 52 years old postmenopausal woman who presented with pelvic pain of four months duration. Gynecologic examination revealed a normal cervix. A possibility of pyometra was considered through pelvic ultrasound. Total abdominal hysterectomy was performed and his...
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... (Zervix, Endometrium) beschrieben. Hierbei muss jedoch zwischen primär auf dem Boden der Ichthyose entstandenen Läsionen (milde Dysplasie, In-situ-Läsion, minimalinvasiv, invasiv; [3,5,9,11,12,15]) und sekundären Neoplasien unterschieden werden. Bei Letzteren liegt der Ursprung des Karzinoms im Bereich der Zervix. ...
Bei der Ichthyosis uteri wird die Oberfläche des gesamten Endometriums durch reifes, gegebenenfalls verhornendes Plattenepithel ersetzt. Die Ursachen können vielfältig sein und sind nicht eindeutig geklärt. Zumeist liegt jedoch ein chronisch-stimulierender, entzündlicher Reiz vor. Eine Assoziation mit einer malignen Neoplasie ist möglich. Ein adäquates, diagnostisches Prozedere sowie eine entsprechende Aufarbeitung des Operationspräparates sind somit notwendig. Anhand eines Fallberichtes wird dieser, heutzutage seltene Befund beschrieben sowie ein Überblick über die wesentliche Literatur gegeben.
... To the best of the authors' knowledge, only five cases of PESCC in situ have been reported to date [ Table 1]. 13 16,17 The role of immunohistochemistry is limited, with most studies demonstrating a mutation of the p53 tumour suppressor gene. 18,19 A high Ki-67 in the differential diagnosis for these patients, despite its rarity. ...
Squamous cell carcinoma (SCC) of the endometrium, whether primary or secondary to cervical
cancer, is a rare entity. Primary endometrial squamous cell carcinoma in situ is even more uncommon; it
usually occurs in postmenopausal women and has a strong association with pyometra. We report a 60-year-old
multiparous postmenopausal woman who presented to the Hakeem Abdul Hameed Centenary Hospital, New
Delhi, India, in May 2014 with a lower abdominal swelling corresponding in size to a pregnancy of 26 gestational
weeks and vaginal discharge of one year’s duration. A total abdominal hysterectomy with a bilateral salpingooophorectomy
was performed, which revealed an enlarged uterus with pyometra. Histopathology showed that the
entire endometrial lining had been replaced with malignant squamous cells without invasion of the myometrium.
Immunohistochemistry revealed that the tumour cells were positive for p63 with a high Ki-67 labelling index. No
adjuvant therapy was required and the patient was disease-free at a seven-month follow-up.
Endometrial cancer (EC) is one of the most common cancers with a constantly and steadily growing incidence worldwide. The main reason for EC development, in addition to the female population aging, involves the obesity epidemic and associated hyperinsulinemia. Screening for EC has not been developed. However, endometrial carcinoma (ECa) demonstrates a specific symptomatology and clinical picture, and diagnostic methods are available, sensitive and defined by a certain range of comorbid diseases. These factors allow early ECa diagnosis in 80 %. The methods of treatment are standardized, depending on the stage of RTM and the morphological structure of EC, the age of the patient and allow to achieve 72–76 % of the overall 5-year survival rate. The methods of treatment are standardized, depending on the EC stage, the morphological structure of ECa, and the patient’s age, and allow achieving the 5-year overall survival of 72–76 %. The disease promised a favorable outcome and seemed to be controlled. However, at the end of the last century, researchers started to report the clinical and morphological heterogeneity of ECa, which allowed Ya. V. Bohman to propose a dichotomous division of EC into clinical and pathological variants. Such a division was accepted all over the world and required re-evaluation of the prognostic value of various endometrial adenocarcinoma histotypes depending on the phenotype and hormonogenesis of ECa. Initially, adenosquamous cancer (or endometrioid adenocarcinoma with squamous metaplasia, in the modern classification) was also classified as estrogen-dependent endometrioid adenocarcinoma, and squamous cell endometrial cancer was classified as an unfavorable type with a poor prognosis and without hormonal influence. Interest in the squamous cell component in dimorphic endometrial adenocarcinoma has repeatedly arisen over the past decades due to its unpredictable clinical course. The newest TCGA molecular classification of EC did not clarify the issues, but gave rise to new ones related to the etiology and carcinogenesis of this ECa histotype and its clinical interpretation.
Ichthyosis uterus is an uncommon condition in which the entire surface of the endometrium is replaced by stratified squamous epithelium. This condition most commonly develops secondary to longstanding cervical obstruction or chronic inflammation. It is considered a benign lesion, but its association with endometrial malignancy has been reported in the literature. We are reporting a case of ichthyosis uteri with dysplasia associated with cervical intraepithelial neoplasm (CIN III). The case is reported for its rarity and to aware about neoplastic potential of ichthyosis uteri.
Primary squamous cell carcinoma of the endometrium is a rare entity with primary endometrial squamous cell carcinoma in-situ
being more uncommon. We report a 60-year-old multiparous post-menopausal woman who presented with a lower abdominal
swelling alongwith difficulty in urination since five months. Total abdominal hysterectomy with bilateral salpingo-oophorectomy
showed an enlarged uterus with pyometra. A diagnosis of primary squamous cell carcinoma in-situ of the endometrium was made
on histopathology.
