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Serum adiponectin in IGT, DM, Obese-Control and Non-obese-Control subjects Note. Error bars show 95.0% CI of mean; dots show means.
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The aim of our study was to evaluate adiponectin and uric acid level in subjects with pre-diabetes and to compare it with the levels in newly diagnosed type 2 diabetes and healthy subjects. We also studied associations of adiponectin level with various anthropometric measurements, indices of glucose metabolism, insulin resistance and uric acid conc...
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Objectives
Moderate-intensity exercise improves insulin sensitivity, which may depend on the intensity, duration, and frequency of exercise. We examined the effects of a single bout of short-duration high-intensity exercise (HIE) and long-duration lowintensity exercise (LIE) on insulin sensitivity and the adiponectin/leptin ratio in individuals wit...
Metabolically healthy (MH) and metabolically unhealthy (MUH) phenotypes can be present in any subject independently of their body mass index (BMI). However, factors related to the presence of these phenotypes are poorly understood. Therefore, the aim of this cross-sectional study is to describe the prevalence and characteristics associated with the...
Abstract
Background: The aim of our study was to evaluate adiponectin
level in subjects with pre-diabetes and to compare it
with the levels in newly diagnosed type 2 diabetes and healthy
subjects. We also studied associations of adiponectin level
with other metabolic indices.
Methods and methods: study included 48 individuals
with pre-diabetes (IGT...
Results from previous prospective studies assessing the relation between adiponectin and type 2 diabetes (T2D) were not entirely consistent, and evidence in Chinese population is scarce. Moreover, the last meta-analysis did not examine the impact of metabolic variables on the adiponectin-T2D association. Therefore, we prospectively evaluated the ad...
The purpose of this study was to investigate (1) the association among anthropometric measurements, cardiopulmonary fitness, liver enzymes and inflammatory markers including vaspin levels among male adolescents, and (2) the effects of a 12 week aerobic exercise training on insulin resistance, liver enzymes and inflammatory markers including vaspin...
Citations
... IL-6 was correlated linearly with BMI and WC in the study of Kluppelholz et al. [26], Malenica et al. [27], and Agrawal et al. [28]. Similarly, Harsoor et al. [29] and Kafle and Shrestha [20] showed a positive association of fibrinogen with BMI while Urbanavicius et al. [30] depicted positive correlation of uric acid with BMI and WHR. ...
Objective: In this study, the main objective was to evaluate the association of markers of obesity with the inflammatory markers in pre-diabetes and diabetes. Methods: This study recruited 300 participants (100 control group, 100 pre-diabetic group, and 100 diabetic group). The anthropometric variables such as body mass index (BMI), waist-hip ratio (WHR), and waist circumference (WC), and biochemical variables such as fasting blood glucose, glycated hemoglobin, uric acid, C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), and adiponectin were analyzed in each participant by standard methods. Results: The present study documented significantly high values of BMI and WHR in patient (pre-diabetic and diabetic) groups compared to the control group. Similarly, the level of adiponectin decreased and that of uric acid, CRP, fibrinogen, and IL-6 increased significantly. Both BMI and WC were correlated significantly with inflammatory mediators in diabetic patients. The correlation with adiponectin was negative. In the pre-diabetic group, a significant correlation was observed only between WHR, adiponectin, and uric acid. Conclusion: This study supports the fact that obesity-induced systemic inflammation of low grade is significantly associated with pre-diabetes and diabetes, thereby keeping these individuals at high risk of future complications especially cardiovascular diseases.
... Adiponectin was found to be significantly lower (p<0.001) in the diabetic group (23.6 + 10.5 ug/ml) compared to the pre-diabetic (67.6 + 10.6) and normal groups (143.9 + 11.6 ug/ml), also, the post-hoc analysis revealed that adiponectin levels of the prediabetic group was significantly lower than the normal group (D<P<N). To assess adiponectin levels and influence of insulin resistance, the subjects were further divided based on homeostatic model assessment of insulin resistance (HOMA-IR) into insulin sensitive (HOMA-IR < 3) and insulin-resistant (HOMA-IR > 3) groups, similar to the previous study of Urbanavičiu et al. (2008) [17] (Table 3). Adiponectin was found to be significantly lower (p=0.014) in insulin-resistant group [(Mean + SEM) 57.1 + 11.2 ug/ml] compared to the insulinsensitive subjects (95.1 + 9.9 ug/ml). ...
... Adiponectin was found to be significantly lower (p<0.001) in the diabetic group (23.6 + 10.5 ug/ml) compared to the pre-diabetic (67.6 + 10.6) and normal groups (143.9 + 11.6 ug/ml), also, the post-hoc analysis revealed that adiponectin levels of the prediabetic group was significantly lower than the normal group (D<P<N). To assess adiponectin levels and influence of insulin resistance, the subjects were further divided based on homeostatic model assessment of insulin resistance (HOMA-IR) into insulin sensitive (HOMA-IR < 3) and insulin-resistant (HOMA-IR > 3) groups, similar to the previous study of Urbanavičiu et al. (2008) [17] (Table 3). Adiponectin was found to be significantly lower (p=0.014) in insulin-resistant group [(Mean + SEM) 57.1 + 11.2 ug/ml] compared to the insulinsensitive subjects (95.1 + 9.9 ug/ml). ...
... Decreased serum adiponectin levels in insulin resistant compared to insulin sensitive group may be due to its association with insulin sensitization. The findings of this study show that adiponectin secretion is closely related to insulin resistance and insulin sensitivity appear to be a major determinant of adiponectin levels, consistent with previous studies [7,17]. In Table 4, the partial correlation of adiponectin among other variables in all of the subjects is shown. ...
Adiponectin is an adipocyte-derived peptide that acts as a hormone with anti-inflammatory and insulin-sensitizing properties. Lower serum levels of adiponectin have been consistently associated with increased risk of type 2 diabetes in numerous prospective studies of diverse nationalities. However, few studies among Filipinos were documented. The objective of this study is to identify if adiponectin could serve as a biomarker of type 2 diabetes mellitus among Filipino respondents by determining the association of its levels with the presence of impaired fasting blood glucose, type 2 diabetes mellitus, insulin resistance and other anthropometric parameters. This study, conducted in University of Santo Tomas Hospital-Out Patient Department, compared the levels of adiponectin in normal, pre-diabetic and diabetic groups, with each having 28 randomly selected samples and equivalent gender ratio. Blood samples were analyzed for fasting blood glucose (FBS), insulin and adiponectin. Homeostatic model assessment of insulin resistance (HOMA-IR) was also computed. Adiponectin and insulin levels were determined using enzyme-linked immunosorbent assay (ELISA). Adiponectin was significantly decreased (p<0.001) in diabetic (23.6 ± 10.5 ug/ml) and pre-diabetic (67.6 ± 10.6 ug/ml) groups compared to the normal group (143.9 ± 11.6 ug/ml). It was also found to have a significant inverse correlation with FBS (rxy.z=-.370, p= 0.001), and HOMA-IR (rxy.z=-.326, p= 0.003) in all of the subjects. Serum adiponectin was also significantly decreased in insulin-resistant (HOMA-IR > 3) compared to insulin-sensitive (HOMA-IR < 3) subjects (57.1 ± 11.2 ug/ml vs. 95.1 ± 9.9 ug/ml; p= 0.014). The researchers conclude that lower adiponectin level is associated with insulin resistance and development of type 2 diabetes mellitus.
... Although the associations of a low adiponectin concentration with obesity and type 2 diabetes mellitus are rather well studied, the data on adiponectin metabolism in morbidly obese diabetic patients and on the changes following a significant weight loss after bariatric surgery in these patients are still lacking. Our (24,25) and other studies (23) have previously demonstrated that patients with type 2 diabetes mellitus have the reduced levels of adiponectin when compared with nondiabetic subjects with similar anthropometric characteristics. In our present study, there was no significant difference in the adiponectin levels in the morbidly obese nondiabetic and diabetic subjects. ...
... The findings of our present study are consistent with the results of other studies (29,30) and our previous studies (24,25) and demonstrate that the adiponectin level correlates negatively with the indices of insulin resistance rather than with the measures of overall obesity such as BMI in both diabetic and nondiabetic morbidly obese patients. The leptin concentration correlates positively with BMI, but the association of this adipokine level and insulin resistance is more complex and warrants further investigation. ...
Objective:
The aim of the study was to evaluate blood glucose, insulin resistance indices, and adipokine (leptin and adiponectin) levels in morbidly obese individuals with and without type 2 diabetes mellitus and to compare the changes in these parameters 1 year after laparoscopic adjustable gastric banding surgery.
Material and methods:
In total, 103 patients (37 subjects with and 66 subjects without type 2 diabetes mellitus) were studied preoperatively and again 1 year after laparoscopic adjustable gastric banding.
Results:
One year after laparoscopic adjustable gastric banding, the leptin concentrations decreased significantly in both treatment groups, while the adiponectin levels increased significantly in the nondiabetic patients (11.19 µg/mL [SD 7.20] vs. 15.58 µg/mL [SD 7.8], P=0.003) and tended to increase in the group of the patients with type 2 diabetes mellitus (8.98 µg/mL [SD 6.80] vs. 13.01 µg/mL [SD 12.14], P>0.05). A considerable decrease in the insulin resistance indices was noted in the patients with type 2 diabetes mellitus 1 year after the intervention, and it was followed by a partial or complete remission of type 2 diabetes mellitus in 23 (85.19%) of the 27 investigated diabetic patients. The postoperative insulin resistance indices in the patients with type 2 diabetes mellitus became similar to the values in the nondiabetic subjects.
Conclusions:
Weight loss after laparoscopic adjustable gastric banding is associated with a significant increase in adiponectin secretion in nondiabetic morbidly obese patients and with improvement in adiponectin secretion in type 2 diabetes individuals. In subjects with type 2 diabetes, this surgical intervention results in a significant reduction in blood glucose and insulin resistance.
Background and Aims: Prediabetes, a category of incipient hyperglycemia that includes impaired fasting glycemia (IFG) and impaired glucose tolerance (IGT), has an increasing incidence in the modern world. We searched for differences in anthropometric and metabolic characteristics between subjects with isolated IFG and IFG+IGT. Material
and Methods: In our cross-sectional study, 154 subjects with IFG and IFG+IGT, without any other major pathologies, were analyzed. Anthropometric data, lipid profile, uric acid, insulin resistance indexes, adiponectin, leptin and leptin-to-adiponectin ratio were compared. Results: Only 122 subjects (64 with isolated IFG and 58 with IFG+IGT), without any other identifiable major disease, were included in the final analysis. Most characteristics of the two groups were similar, only minor differences in anthropometric data, biochemical profile and insulin resistance indexes being noted. Insulin resistance indexes were stronger associated with adiponectin in the group with isolated IFG and with leptin and leptin-to-adiponectin ratio in the IFG+IGT group. Conclusions: Our data suggest a similar anthropometric and metabolic profile in subjects with isolated IFG and with IFG+IGT. In isolated IFG, insulin resistance seems to correlate better with adiponectin, while in IFG+IGT it seems to associate mostly with leptin and derived parameters
