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Objective
. To assess the level of 25-hydroxyvitamin D status among a sample of Egyptian schoolchildren and to evaluate predictors of deficiency and insufficiency.
Subjects and Methods
. A cross-sectional study comprising 200 prepubescent schoolchildren aged from 9 to 11 years was performed. A questionnaire including frequency of midday sun exposur...
Context in source publication
Context 1
... serum 25(OH)D < 30 ng/mL was found in 53 subjects (26.5%). Table 1 shows serum 25(OH)D in relation to studied variables presumed precarious for vitamin D insufficiency. Females, obese children, children of low educated level moth- ers, children with low physical activity, and children with milk intake less than once/day had statistically significant lower serum 25(OH)D than their peers (í µí± < 0.005). ...
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Vitamin D (VD) is unique among the vitamins in the fact that it can either be synthesized in the skin from exposure to
sunlight or taken from the diet. Apart from its role in calcium and bone homeostasis, VD and its metabolites are now known
to have important roles in various other functions of human health, of which many still await to be discover...
Recent studies have shown that in spite of being generally close to the equator; vitamin D deficiency is common in South East Asian countries. In order to quantify micronutrient status for women and children in Cambodia; a nationally-representative survey was conducted in 2014 linked to the Cambodian Demographic Health Survey. The countrywide media...
Mounting evidence from observational and clinical trials indicates that optimal vitamin D reduces the risk of many diseases. We used observational studies and recent data on 25-hydroxyvitamin D [25(OH)D] concentrations of Canadians from Cycle 3 of the Canadian Health Measures Survey to estimate the reduction in disease incidence, mortality rates, a...
Citations
... miR-146a, miR-150, and miR-155 have been identified as related to vitamin D. 25 Several studies have found a significant inverse relationship between vitamin D and BMI. 14,26 However, in this study, there was no significant difference between BMI and vitamin D levels (p=0.374) (TABLE 4). ...
Obesity is one of the causes of chronic diseases, such as diabetes, hypertension, stroke, cancer, dyslipidemia, and heart disease. It is considered a financial burden on national health insurance since it drains the largest health fund. The study aimed to determine the difference in vitamin D levels in obese and non-obese health workers and analyze the factors that influence it. This was a cross-sectional study of the obese and non-obese health workers at Dr. Sardjito General Hospital, Yogyakarta. A total of 50 subjects, including 25 obese and 25 non-obese subjects were involved. Serum vitamin D levels was determined by ELISA. There was no significant difference between the obese and non-obese groups on vitamin D status (p<0.365). Vitamin D deficiency was found in 10% of subjects, whereas insufficient vitamin D levels were found in 46 and 44% of subjects, respectively. Vitamin D deficiency was more common in the obese (12%) than non-obese (8%) group. Contrarily, vitamin D insufficiency was more common in the non-obese (56%) than obese (36%) group. The serum vitamin D levels in the obese [30.08 (14.67-101.71) ng/mL] was not significantly different compare to those non-obese [28.54 (14.38-54.41) ng/mL] (p = 0.691). The multivariate analysis significantly showed that outdoor activities <30 min had a 7.061 times greater risk of having vitamin D deficiency/insufficiency compared to outdoor activities >30 min (OR 7.061; 95% CI: 1.064-46.872; p=0.043). In conclusion, there is no significant difference in vitamin D levels between the obese and non-obese groups. Vitamin D deficiency/insufficiency is more common in non-obese subjects than in obese subjects. Outdoor activity <30 min is a risk factor for vitamin D insufficiency/deficiency despite living in a tropical country with abundant sunlight throughout the year.
... In children with DCM, it can be attributed to inadequate sunlight exposure, restricted outdoor play, and lying down position, as well as to poor vitamin D absorption because of edema of the intestinal wall in DCM patients. (Green et al., 2015;Abu Shady et al., 2016). ...
Child heart failure is frequently brought on by dilated cardiomyopathy and it is characterized by impaired contraction and left ventricular or biventricular dilation. Evidence from recent years has demonstrated that vitamin D is crucial in a number of cardiovascular illnesses that are now more well recognized. This study evaluated vitamin D status in pediatric patients with dilated cardiomyopathy and compared it with that of healthy controls. This study is an observational case-control study, which included 23 patients with dilated cardiomyopathy aged less than 21 years of both genders, and a control group that included 45 healthy people who were matched for age, sex, and body mass index at the surgical specialty hospital-cardiac center in Erbil, Iraq. From each one, a blood sample was taken to evaluate the serum level of 25-hydroxyvitamin D3, parathyroid hormone, phosphorus, calcium, troponin I and creatin kinase-MB levels. The study revealed that the mean serum vitamin D3 level and mean serum calcium were significantly lower in dilated cardiomyopathy patients than controls, and significantly higher mean serum PTH and serum creatin kinase-MB in patients than controls. The difference in serum troponin I levels was not significant between the two groups. Furthermore, the study's outcomes revealed a substantial, moderately significant negative correlation between hypovitaminosis D and the dimensions of the left ventricle's end diastole and end systole in children with dilated cardiomyopathy
... The current study found no relation between serum levels of vitamin D and the sex of the child; this result is in line with another Egyptian study carried out by Abu Shady et al. [21], which found no significant difference in the mean serum vitamin D levels in relation to the sex of the child. However, this result is not in line with studies carried out in Saudi Arabia, Kuwait, and Canada by Sultan et al. [13], Al-Taiar et al. [18] and Naugler et al. [22], respectively, which revealed significant differences in the mean vitamin D levels among both boys and girls. ...
... The current study shows that there is no relationship between serum levels of vitamin D and BMI; this result is in agreement with the study carried out in Iran by Gheibi et al. [23], which showed that there was no relation between the serum levels of vitamin D and BMI. However, contrary to our finding, this result is not in line with other Egyptian studies carried out by Shebl et al. [24] and Abu Shady et al. [21], which showed that the concentration of vitamin D had a significantly negative correlation with BMI. ...
Background: Vitamin D is a secosteroid hormone that is well known to play a systemic role in calcium homeostasis, skeletal metabolism, cellular differentiation, apoptosis, anti‑proliferation, immunosuppression and anti-inflammation. Objectives:To estimate the prevalence of vitamin D deficiency and associated factors among preschool children in a rural area in Upper Egypt. Patients and methods: A cross‑sectional study was carried out on 180 preschool children who attended the selected family health facilities in El‑Dakhla District, New Valley Governorate, Egypt. This study was carried out over a timeframe of 24 months (starting from the 1st of February 2019 until the end of January 2021). Data were collected through an interview with mothers on past family and personal history, in addition to the assessment of socioeconomic status, examination and laboratory investigations to assess the serum levels of vitamin D. Results: More than half of the studied children had vitamin D deficiency, 54.4% . More than one third of them showed vitamin D insufficiency (37%), while only 8.9% of the children had normal levels of vitamin D. Delayed dental protrusion and profuse head sweats were significantly higher among vitamin D-deficient children than in children with normal levels of vitamin D. There was a statistically significant difference between vitamin D-deficient children and children with normal levels of vitamin D in terms of mother’s age, mother’s education, breast‑feeding and sun exposure. Conclusion: The prevalence of vitamin D deficiency among preschool children was 54.4%. Maternal education and duration of breastfeeding significantly affect serum levels of vitamin D of their children. There is a positive significant correlation between serum levels of vitamin D and the height of children.
... Despite abundance of sunlight in Middle East and Egypt, studies that assessed vitamin D status revealed high prevalence of vitamin D deficiency and insufficiency that could be attributed to being with darker skin, nutritional factors, and cultural and traditional issues. 24,25 While in children with heart failure, it can be explained by decreased sunlight exposure with reduced outdoor activities and recumbent position together with defective absorption of vitamin D due to edema affecting intestinal wall. 26 Deficiency and insufficiency of vitamin D are observed in toddlers and young-aged Egyptian children. ...
... Abu Shady et al in 2016 observed that vitamin D less than 20 ng/mL was seen in 11.5% of healthy Egyptian school-aged children, while vitamin D insufficiency (>20 and <29.9 ng/mL) was observed in 15%. 25 Our study showed that vitamin D deficiency was highly prevalent (up to 90.1%) among children with idiopathic DCM and 9.1% was with sufficient 25(OH) vitamin D level, and this observation could raise the attention toward the possible contributing role of vitamin deficiency in the pathogenesis of idiopathic DCM. ...
Dilated cardiomyopathy (DCM) is the third leading cause of heart failure in pediatrics. The exact etiology of DCM is unknown in more than half of the cases. Vitamin D receptors are represented in cardiac muscles, endothelium, and smooth muscles of blood vessels suggesting that vitamin D could have a vital cardioprotective function. This study aimed to assess serum level of vitamin D in children with idiopathic DCM and to correlate the serum level of vitamin D with the left ventricular dimensions and function. This study is a descriptive cross-sectional single-center study, includes 44 children of both sexes, diagnosed as idiopathic DCM. Serum level of vitamin D was assessed and correlated with the left ventricular dimensions and function. Mean age of studied children was 6.08 ± 4.4 years. Vitamin D deficiency was found in 90.9% of children with idiopathic DCM with a mean level 13.48 ng/mL. There was a negative correlation between vitamin D level and fraction shortening and left ventricular end-diastolic diameter in children with DCM. Vitamin D level is not only significantly low in children with idiopathic DCM but it is also significantly correlated with the degree of left ventricular dysfunction.
... Despite abundance of sunlight in Middle East and Egypt, studies that assessed vitamin D status revealed high prevalence of vitamin D deficiency and insufficiency that could be attributed to being with darker skin, nutritional factors, and cultural and traditional issues. 24,25 While in children with heart failure, it can be explained by decreased sunlight exposure with reduced outdoor activities and recumbent position together with defective absorption of vitamin D due to edema affecting intestinal wall. 26 Deficiency and insufficiency of vitamin D are observed in toddlers and young-aged Egyptian children. ...
... Abu Shady et al in 2016 observed that vitamin D less than 20 ng/mL was seen in 11.5% of healthy Egyptian school-aged children, while vitamin D insufficiency (>20 and <29.9 ng/mL) was observed in 15%. 25 Our study showed that vitamin D deficiency was highly prevalent (up to 90.1%) among children with idiopathic DCM and 9.1% was with sufficient 25(OH) vitamin D level, and this observation could raise the attention toward the possible contributing role of vitamin deficiency in the pathogenesis of idiopathic DCM. ...
Dilated cardiomyopathy (DCM) is the third leading cause of heart failure in pediatrics.
The exact etiology of DCM is unknown in more than half of the cases. Vitamin D
receptors are represented in cardiac muscles, endothelium, and smooth muscles of
blood vessels suggesting that vitamin D could have a vital cardioprotective function.
This study aimed to assess serum level of vitamin D in children with idiopathic DCM and
to correlate the serum level of vitamin D with the left ventricular dimensions and
function. This study is a descriptive cross-sectional single-center study, includes 44
children of both sexes, diagnosed as idiopathic DCM. Serum level of vitamin D was
assessed and correlated with the left ventricular dimensions and function. Mean age of
studied children was 6.08�4.4 years. Vitamin D deficiency was found in 90.9% of
children with idiopathic DCM with a mean level 13.48ng/mL. There was a negative
correlation between vitamin D level and fraction shortening and left ventricular enddiastolic
diameter in children with DCM. Vitamin D level is not only significantly low in
children with idiopathic DCM but it is also significantly correlated with the degree of left
ventricular dysfunction.
... A total of 44% of patients with CP had vitamin D deficiency, whereas it was 10% in the control participants. This was similar to a study among Egyptian normal school children who reported vitamin D deficiency (serum 25-OH-D <20 ng/ml) in 23 patients (11.5%) [13] and stated that this prevalence was lower than reported from different countries and attributed this difference to the sunny climate in Egypt in comparison with that in Europe as well as the USA. ...
Objective
The current study was conducted to evaluate vitamin D status in children with cerebral palsy (CP) and its relations with associated risk factors.
Patients and methods
The present research included 50 children with CP of both sexes compared with a control group of 20 healthy children with matched age and sex. Serum 25-hydroxyvitamin D, serum calcium, and phosphorus were measured and compared in cases and controls. The Gross Motor Function Classification System (GMFCS) was recorded, and children with GMFCS level I–III were considered ambulatory, whereas children with level IV–V were considered nonambulatory.
Results
Median (interquartile range) serum vitamin D levels exhibited a significant decrease in the CP group (22.2 (14.48) ng/dl) as compared with the controls (33.1 (7.8) ng/dl). Twenty-two (44%) children with CP were vitamin D deficient versus two (10%) control groups. A significant difference was found in serum vitamin D level in those who were nonambulatory, had feeding problems in comparison with those who were ambulatory, and had no feeding problems. At the same time, there was no significant difference regarding antiepileptic drugs (AEDs) use. Serum vitamin D level was inversely correlated with nonambulation and feeding problems, whereas the correlation was not significant regarding AEDs use.
Conclusion
Children with CP are susceptible to vitamin D deficiency, especially those who are nonambulatory, having feeding problems, whereas those who used AEDs are not.
... Matched with our findings, Abu Shady et al. [20] in Egypt found that VDD was significantly lower in obese than nonobese patients, as well as in low physical activity than those with high physical activity (P<0.05). The same results were stated in a study done in Emirates, which found an inverse correlation between serum 25-OHD concentrations with BMI and a positive correlation with physical activity after adjustment for age [21]. ...
... In a cross-sectional study that involved 200 prepubescent school children aged 9-11, vitamin D deficiency (<20 ng/mL) was detected in 11.5% of subjects, while its insufficiency (levels between 20 and 29.9 ng/mL) was detected in 15%. Obesity, low physical activity, low sun exposure, and low maternal education level were significant predictors of insufficiency, while female gender, low maternal education level, and low milk intake were significant predictors of deficiency [29]. ...
Propionic and methylmalonic acidemias result in multiple health problems including increased risk for neurological and intellectual disabilities. Knowledge regarding factors that correlate to poor prognosis and long-term outcomes is still limited. In this study, we aim to provide insight concerning clinical course and long-term complications by identifying possible correlating factors to complications. Results. This is a retrospective review of 20 Egyptian patients diagnosed with PA (n = 10) and MMA (n = 10) in the years 2014-2018. PA patients had lower DQ/IQ and were more liable to hypotonia and developmental delay. The DQ/IQ had a strong negative correlation with length of hospital stay, frequency of PICU admissions, time delay until diagnosis, and the mode ammonia level. However, DQ/IQ did not correlate with age of onset of symptoms or the peak ammonia level at presentation. Both the growth percentiles and albumin levels had a positive correlation with natural protein intake and did not correlate with the total protein intake. Additionally, patients on higher amounts of medical formula did not necessarily show an improvement in the frequency of decompensation episodes. Conclusion. Our findings indicate that implementation of NBS, vigilant and proactive management of decompensation episodes, and pursuing normal ammonia levels during monitoring can help patients achieve a better neurological prognosis. Furthermore, patients can have a better outcome on mainly natural protein; medical formula should only be used in cases where patients do not meet 100-120% of their DRI from natural protein.
... Tunisian children and adolescents, are exposed to a high risk of vitamin D inadequacy despite living in a sunny climate (Bezrati et al., 2016). Among Egyptian prepubescent children, there is a high prevalence of vitamin D deficiency especially among children which may increase the risk of many chronic diseases in adulthood (Abu Shady et al., 2016). The aim of this study is to assess the knowledge and practice of Vitamin D deficiency before and after a health education program in between. ...
... A study conducted with 529 children between 5 and 10 years of age in Acrelândia, in inner Acre, western region of the Brazilian Amazon, found a prevalence of 8.7% of vitD deficiency [4]. Another study [3] found a prevalence of 28.9% vitD deficiency among healthy children (5-10 years of age) in Qatar, a country with mild winters and very hot and humid summers, but with Muslim habits of traditional clothing covering a large part of the body, including children, and may interfere with vitD skin synthesis [25]. On the other hand, our data of insufficiency and mean values of 25 (OH) D were similar to those of 200 prepubescent schoolchildren (9 and 10 years old) in Egypt, also a predominantly Muslim country. ...
... The mean serum 25 (OH) D in the mentioned study was 41.25 ± 13.95 ng/mL (15-65 ng/mL), with prevalence of 15% insufficiency. However, the prevalence of deficiency found by them was 11.5% [25]. ...
Background:
In children, nutritional status of vitamin D (vitD), frequency of vitD receptor (VDR) gene polymorphisms and their associations with overweight and asthma remain controversial.
Objectives:
To evaluate the nutritional status of vitD and the frequency of VDR gene polymorphisms, as well as identify their associations with nutritional status and asthma.
Methods:
A cross-sectional study was conducted with schoolchildren (n = 262; mean age = 8.7 ± 1.3 years). Clinical history, anthropometric measurements, and serum 25-hydroxy vitD were evaluated. Four VDR gene polymorphisms were identified and genotypes, alleles, and haplotypes were calculated.
Results:
The serum vitD levels were found at 85.1%, within normal range. The FokI AA genotype was more frequent in asthmatics compared to healthy controls (10 vs. 1%, p < 0.05), while the GG genotype was less frequent (45.0 vs. 55.2%, p < 0.05). The frequency of the TT allele for the ApaI was higher among asthmatic eutrophic children (60.9 vs. 29.4%, p < 0.05) and that of the TT allele for the BsmI was higher among asthmatic overweight children (35.3 vs. 4.4%, p < 0.05).
Conclusions:
Insufficiency in vitD was low. Two wild-type alleles (AA) of FokI were identified as risk factor for the development of asthma, while GG alleles appears to be a protective factor. To have polymorphic alleles (TT) of ApaI seems to be a risk factor for asthma in children with normal weight, while that of BsmI seems to be a risk factor for asthma in overweight condition. Serum vitD was not different among analyzed genotypes.
