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Selection of the study group based on the results of concurrent 24-hour BP and esophageal pH monitoring. GERD indicates gastroesophageal reflux disease; BP, blood pressure; HE, high BP episodes; HE dependent on PR, high BP episodes, with at least 1-episode dependent on pathologic reflux.
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Goals:
We assessed the relationship between gastroesophageal reflux disease (GERD) and hypertension and whether antiacid therapy could be used to control blood pressure (BP) on hypertension in patients with GERD.
Background:
Gastroesophageal reflux disease (GERD) may provoke cardiovascular disease. Many factors are involved in the development of...
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Context 1
... the 86 patients with hypertension, 38 patients (44.2%) had GERD (Fig. 1); however, only 24 patients satisfied the criteria that at least 1 high BP episode was time-dependent on the occurrence of PR (Fig. 1). Of these 38 patients who met GERD and hypertension criteria, 25 patients first showed GERD symptoms and the emergence of hypertension were 1 to 10 years later; 13 patients first showed hypertension and ...
Context 2
... the 86 patients with hypertension, 38 patients (44.2%) had GERD (Fig. 1); however, only 24 patients satisfied the criteria that at least 1 high BP episode was time-dependent on the occurrence of PR (Fig. 1). Of these 38 patients who met GERD and hypertension criteria, 25 patients first showed GERD symptoms and the emergence of hypertension were 1 to 10 years later; 13 patients first showed hypertension and the emergence of GERD were 0.8 to 6 years later. The duration of GERD were (8.2 ± 5.6) years and of hypertension were (6.4 ± 4.0) ...
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Background:
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Citations
... Пациенты с ГЭРБ имели значительно более высокое ночное АД, чем пациенты без ГЭРБ. Наблюдение показало, что антисекреторная терапия приводит к нормализации параметров мониторинга АД и рН пищевода [68], а патологические рефлюксы способны вызывать снижение показателей вариабельности сердечного ритма, тем самым провоцируя развитие фатальных аритмий вплоть до внезапной сердечной смерти [69]. ...
... Ряд авторов указывают на побочные эффекты у препаратов групп β-адреноблокаторов и антагонистов кальция, которые применяются для нормализации АД, в частности, снижение тонуса нижнего пищеводного сфинктера, более высокий риск развития эзофагита. Клинически доказано, что в случае сочетанного течения АГ и ГЭРБ применение комбинации ИПП + прокинетик + гипотензивная терапия, приводит к более быстрому исчезновению клиникоэндоскопических симптомов ГЭРБ, в отличие от тех случаев, когда пациенты с сочетанной патологией получали монотерапию ИПП [68,69]. ...
Currently, special attention is drawn to the phenomenon of comorbidity of chronic non-infectious diseases. The emergence of comorbidity is facilitated by the high incidence of coexisting diseases. One such combination is GERD and metabolic syndrome (MS). GERD and MS are multifactorial diseases, the pathogenesis of which is intertwined and mutually aggravates each other. Every year throughout the world and the Russian Federation, there is a clear trend towards an increase in the incidence of pathology of the upper gastrointestinal tract, namely gastroesophageal reflux disease (GERD). The prevalence of obesity in Russia over 40 years of observation has increased 4 times among men and 1.5 times among women. Despite the high incidence, to date there is no diagnosis of “metabolic syndrome” (MS) in ICD-10. MS is coded based on its constituent pathologies (obesity, dyslipidemia, insulin resistance, arterial hypertension). Treatment of this comorbid pathology requires a multidisciplinary approach, thereby placing a high burden on the healthcare system. This article displays the features of the pathogenesis and clinical picture of GERD, as well as the combination of this pathology with the components of MS.
... Participants with co-morbidities were at higher risk for GERD. A study done by [17] reported that out of the total essential 86 hypertension patients, 38 participants have been experiencing GERD (44.2%). These patients were treated with antacid therapy to restore normal esophageal pH and maintain Normal Blood pressure. ...
Gastroesophageal reflux disease (GERD) is a chronic gastrointestinal disease characterized by regurgitation of gastric contents into the esophagus. Over the past ten years, there has been a rise in the number of individuals in the UAE experiencing chronic gastroesophageal reflux disease (GERD). This study aimed to assess the prevalence and factors of GERD among adults in the UAE. The study followed a cross-sectional study design. We included samples from individuals over 18 years old attending the Medi city in Ajman. The research collected data via a self-administered questionnaire. The GERDQ was utilized to assess the prevalence of GERD. Questions regarding the socio-demographic characteristics, lifestyle patterns, and other factors were included in the study. Chi-Square test was used to evaluate the statistical significance of various factors, and binomial and multiple regression analysis was used to determine the factors (p-value < 0.05). The prevalence of GERD was found to be 13.5%, which is significantly higher (19.2%, p=0.019) among adults above 30 years of age. The risk factors identified were age (OR= 3.1, CI: 1.18-8.2), less sleep (OR=2.4, CI: 1.2-4.5), those who have arthritis (OR= 5.2, CI: 2.1-13.2) and depression (OR= 2.
... Частота встречаемости НАЖБП и клинической формы НАСП увеличивается с возрастом (особенно у женщин), что обусловлено тем, что с возрастом в печени снижается скорость кровотока, нарушается клеточный цикл и увеличивается секреция провоспалительных цитокинов. Исследования, проведенные в эксперименте и клинике, доказали влияние процесса старения на развитие и прогрессирование стеатоза печени [13]. ...
The aim. To study risk factors, clinical features, anthropometric, biochemical and metabolic parameters, parameters of the functional state of the endothelium, the level of interleukin-6 (IL-6) and markers of hemostasis in patients with non-alcoholic liver steatosis in the early postmenopausal period living in Perm. Materials and methods. 100 women in the early postmenopausal period were examined: 70 patients with the clinical form non-alcoholic liver steatosis and overweight or obesity of varying severity (49.9±1.1 years) and 30 practically healthy women without obesity and liver pathology (47.3±2.6 years). Biochemical parameters, lipid spectrum, insulin, leptin, leptin receptors, interleukin-6 (IL-6), markers of endothelial dysfunction, hemostasis parameters were determined in the blood of all subjects, body mass index (BMI), free leptin index, NOMA-IR and Caro were calculated. Liver steatosis was determined by ultrasound examination. Results. General weakness (35%), severity (35%) and pain (15%) in the right hypochondrium (35%), dyspepsia - belching (25%), nausea (15%), heartburn (10%), flatulence (10%). Hypertension was observed in 60% of women, type 2 diabetes mellitus - in 24%. All patients had a genoid type of obesity. 34% of women with non-alcoholic liver steatosis were overweight, 29% were obese of the 1st degree, 23% were obese of the 2nd degree, and 14% of patients were obese of the 3rd degree. Conclusion: In the examined women with non-alcoholic liver steatosis in the early postmenopausal period living in Perm, risk factors for the development of obesity were identified: consumption of high-calorie foods with high fat and sugar content and hypokinesia, and the course of the disease was accompanied by the development of dyslipidemia, insulin and leptin resistance, inflammatory syndrome with activation of proinflammatory cytokine IL-6 and hyperfibrinogenemia, and also endothelial dysfunction, the severity of which increased during the transition from 1 to 2-3 degrees of obesity.
... Benzodiazepines, calcium channel blockers, nitrates, β-2 agonists, and xanthines are examples of drugs that can reduce the pressure of the lower esophageal sphincter via the smooth muscle relaxation mechanism (theophylline). They are frequently prescribed annually for conditions like anxiety, hypertension, angina, and asthma (Li et al., 2018). Hypertension treatment options include single or combination anti-hypertensive drugs, lifestyle changes to control blood pressure and relaxation therapy. ...
... Hypertensive medications, such as βblockers and calcium channel blockers (CCBs), can exacerbate GERD symptoms by decreasing lower esophageal sphincter (SEB) tone (Li et al., 2018). Calcium channel blockers (CCBs) can cause GERD and exacerbate existing reflux symptoms. ...
Gastroesophageal Reflux Disease (GERD) prevalence has increased from 2016 to 2018 by 21,6%. Inappropriate indication, drug, dose, route of administration, and time interval of administration could lead to therapeutic failure. This study aimed to evaluate the rationality of drug use and the distribution of drug use patterns in GERD patients at the outpatient installation of RSUD Dr. Soedarso Pontianak. This research method is descriptive and observational with a cross-sectional design. Data collection was delivered retrospectively with medical records data and prescriptions of GERD patients during the 2020-2021 period. The sampling technique used is purposive sampling, where the sample selection is based on the specified inclusion criteria. The sample used in the study was 98 patients. The results showed that the percentage of rationality in patients without comorbidities was based on 100% correct indication, 93,85% correct drug, 100% correct dose, 100% valid route of administration, and 100% accurate time interval for administration and with comorbidities based on proper indication 87,88%, 57,58% correct drug, 100% correct dose, 100% correct route of administration, and 100% accurate time interval for administration. Distribution pattern of GERD drug use in GERD patients without/with comorbidities was the most widely used is Lansoprazole (monotherapy). The most commonly used is a Proton Pump Inhibitor (PPI) with sucralfate for the benefit of combination drugs.
... For respondents' characteristic data about comorbidities, there is an explanation, namely for ulcer disease and GERD, they have similarities in the increase in gastric acid but have differences in severity and effects and symptoms. Research conducted by [30] shows the relationship between GERD and ulcers This study suggests that part of the reflux episode may be associated with increased blood pressure. Antiacid therapy restores esophageal and gastric pH to normal and significantly decreased BP elevation, which suggests that GERD treatment is useful for normalizing blood pressure in hypertensive patients. ...
Moringa leaves, red ginger, turmeric, red meniran, cinnamon, and sambiloto have compounds with antihypertensive activity. The study was to describe the characteristics and effect of decoction 6 plant compositions for reducing the systolic and diastolic blood pressure of respondents in Long Kali District. The method used is quasi-experimental for 7 days. The results show characteristics data respondents for hypertensive patients in Long Kali District occurred the highest in late adulthood (36-45 years) with a percentage of 65%, female sex with a percentage of 75%, family history (hypertension) with a percentage of 65%, other diseases (more than 1 disease) with a percentage of 30%, and BMI obesity I (23.0 – 29.9) 50%. Data on the effect of giving decoction 6 plant compositions had a significant effect for decreased systolic and diastolic blood pressure of pre-test and post-test which was able to reduce the average systolic blood pressure on the third day by 11.7 mmHg (p=0.000) and diastolic blood pressure of 7.2 mmHg (p=0.005) and on the seventh day was also able to reduce the average systolic blood pressure of 9.4 mmHg (p= 0.012) and diastolic blood pressure of 4.9 mmHg (p= 0.030).
... Исследования, проведенные в эксперименте и клинике, доказали влияние процесса старения на развитие НАЖБП. После менопаузы НАЖБП отличается более высокой частотой у женщин, чем у мужчин [6]. По другим данным, НАЖБП чаще регистрируют у женщин в возрасте 40-50 лет, соотношение мужчин и женщин 1:3, хотя заболевание встречается во всех возрастных группах [7][8][9]. ...
Introduction. Non-alcoholic fatty liver disease (NAFLD) increases with age. The main risk factor for NAFLD and the progression of liver fibrosis is obesity. However, the disease also occurs in 7% of people with normal body weight, mainly in young women with normal levels of liver enzymes, in whom liver disease can nevertheless progress. Aim. To assess the features of clinical and laboratory manifestations of non-alcoholic hepatic steatosis (NASP) in women of reproductive age and in menopause, depending on the degree of obesity. Materials and methods. We examined 86 women with NAS and obesity, of which 49 were women of reproductive age (37.3 ± 1.7 years) and 37 patients in menopause (51.3 ± 1.0 years). Determined: transaminases, total bilirubin, glucose, lipid spectrum, insulin, leptin, interleukin-6 (IL-6), vasculoendothelial growth factor (VEGF); body mass index (BMI), atherogenicity index (AI), and HOMA-IR index were calculated. Liver steatosis was determined by ultrasound, fibrosis was excluded by fibroelastography. Results. The clinic in both groups of women was poor; there were no signs of liver fibrosis. In women with liver steatosis with concomitant obesity in reproductive age and menopause, dyslipidemia, hyperleptinemia, increased levels of IL-6 and signs of endothelial damage in the form of VEGF hyperproduction are recorded. At the same time, dyslipidemia and hyperleptinemia are significant in menopause, and in women with steatosis at reproductive age, signs of endothelial damage are more pronounced. Conclusion. In both groups of women with the clinical form of NASP, most of the studied laboratory parameters marked the transition to stage 1 obesity, leptin made it possible to differentiate almost all degrees of obesity, and the production of IL-6 and VEGF significantly increased at stages 2–3 of obesity.
... Cluster 4: Esophageal reflux or Gastroesophageal reflux disease (530.81) that appears in all patterns frequently coexists with hypertension (401.9) [52], or with coronary artery disease (414.01) [53], or with hyperlipidemia (272.4) ...
A Relational-Sequential dataset (or RS-dataset for short) contains records comprised of a patients values in demographic attributes and their sequence of diagnosis codes. The task of clustering an RS-dataset is helpful for analyses ranging from pattern mining to classification. However, existing methods are not appropriate to perform this task. Thus, we initiate a study of how an RS-dataset can be clustered effectively and efficiently. We formalize the task of clustering an RS-dataset as an optimization problem. At the heart of the problem is a distance measure we design to quantify the pairwise similarity between records of an RS-dataset. Our measure uses a tree structure that encodes hierarchical relationships between records, based on their demographics, as well as an edit-distance-like measure that captures both the sequentiality and the semantic similarity of diagnosis codes. We also develop an algorithm which first identifies k representative records (centers), for a given k, and then constructs clusters, each containing one center and the records that are closer to the center compared to other centers. Experiments using two Electronic Health Record datasets demonstrate that our algorithm constructs compact and well-separated clusters, which preserve meaningful relationships between demographics and sequences of diagnosis codes, while being efficient and scalable.
... Single liveborn, born in hospital, delivered without mention of cesarean section V46. 2 Dependence on supplemental oxygen V49. 86 Do not resuscitate status V58. 66 Long-term (current) use of aspirin V58. ...
Clustering data derived from Electronic Health Record (EHR) systems is important to discover relationships between the clinical profiles of patients and as a preprocessing step for analysis tasks, such as classification. However, the heterogeneity of these data makes the application of existing clustering methods difficult and calls for new clustering approaches. In this paper, we propose the first approach for clustering a dataset in which each record contains a patient's values in demographic attributes and their set of diagnosis codes. Our approach represents the dataset in a binary form in which the features are selected demographic values, as well as combinations (patterns) of frequent and correlated diagnosis codes. This representation enables measuring similarity between records using cosine similarity, an effective measure for binary-represented data, and finding compact, well-separated clusters through hierarchical clustering. Our experiments using two publicly available EHR datasets, comprised of over 26,000 and 52,000 records, demonstrate that our approach is able to construct clusters with correlated demographics and diagnosis codes, and that it is efficient and scalable.
... By controlling acid reflux and reducing body weight, high BP can be managed. [4][5][6] Many studies have shown evidence pointing towards a moderate association between obesity and gastroesophageal reflux disease (GERD). One probable mechanism associating obesity with GERD may be that excess adipose tissue in obese individuals tends to create external abdominal pressure, causing an increase in intra-gastric pressure, resulting in relaxation of the lower esophageal sphincter, that in turn allows the gastric contents to travel backwards from the stomach. ...
Acid reflux and acidity are common gastrointestinal disorders having great impact on a patient's quality of life. The drugs usually prescribed to provide promising results often mask unresolved physiological problems and cause further complications.
The subject of this study is a 49-year-old female who presented at the Health Total centre with hypertension along with moderate knee pain and pedal oedema associated with her history of osteomalacia. Her medical history revealed parathyroid surgery and an aggravated acid reflux condition. The aim of this case study is to evaluate the impact of an integrated treatment regimen that comprises nutrition, herbs and lifestyle modifications on disease manifestation and progression.
The patient’s gastritis symptoms were rectified with the use of this ‘Integrated Approach.’ She also showed a gradual and sustained reduction in weight and BMI, normalization of blood pressure, along with relief from knee pain.
The association between omeprazole and hypertension is poorly documented. The summary of product characteristics of omeprazole approved by major regulators did not mention hypertension as an adverse drug event. Triggered by a locally reported case, this study was conducted to assess the possible causal relationship between omeprazole and hypertension.
Globally reported cases of hypertension following use of omeprazole submitted to the World Health Organization global database, VigiBase, were retrieved on 5 March 2024 and analyzed descriptively. Besides this, a literature search was made to identify preclinical, clinical, and epidemiological information on the association between omeprazole and hypertension or increased blood pressure using different data sources. Relevant information, gathered from different data sources, was finally systematically organized into an Austin Bradford-Hill causality assessment framework to assess the causal relationship between omeprazole and hypertension.
VigiBase indicated a total of 1043 cases of hypertension related to omeprazole from 36 different countries. In the global database, a statistical signal was triggered (IC025: 0.12) on association of omeprazole and hypertension. From the 1043 cases, 65.0% and 10.6% were reported as ‘serious’ and ‘fatal’, respectively. Hypertension resolved following withdrawal of omeprazole in 85 cases and recurred after re-introduction of the suspect drug in 14 cases. In 225 cases, omeprazole was the only suspected drug, while in 122 cases, omeprazole was the sole drug administered. When only these 122 cases were considered, 29 cases had positive dechallenge, four cases were with positive rechallenge and the median time-to-onset was 2 days. Literature search identified a possible biological mechanism and some experimental evidence that indicates omeprazole could possibly cause hypertension.
Currently available totality of evidence suggests there is a possible causal relationship between omeprazole and hypertension. Hence, it is recommended to monitor and report any incidence of hypertension related to omeprazole, and further epidemiological studies are recommended to corroborate the suggested causal association.
