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Source publication
Excessive amounts of reactive oxygen species (ROS), unless counterbalanced by antioxidants, can cause cellular damage under oxidative stress conditions; therefore, antioxidative defenses against ROS must be measured. With the development of nanotechnology, nanoparticles have found numerous applications in science, health, and industries. Magnetite...
Citations
... They use N,N-dimethyl-p-phenylenediamine (DMPD) probe ( • OH detector) and F3O4 NPs with the size of 20-30 nm. They showed that in concentration around 0.1 mg/ml, absorbance of solution (F3O4 NP + DMPD) was around 0.6 [72]. While we sense among of • OH with Terephthalic acid + Core: citric acid: PEG: ICG: PpIX MNPs in presence of magnetic field and achieve high amount of • OH production in with combination of MNPs and magnetic field. ...
Background
Cancer stem cells (CSCs) are the most challenging issue in cancer treatment, because of their high resistance mechanisms, that can cause tumor recurrence after common cancer treatments such as drug and radiation based therapies, and the insufficient efficiency of common treatments in CSCs removal and the recurrence of tumors after these treatments, it is essential to consider other methods, including non-ionizing treatments likes light-based treatments and magnetic hyperthermia (MHT).
Method and material
After synthesis, characterization and investigation, the toxicity of novel on A375 and MAD-MB-231 cell lines, magnetic hyperthermia and light-based treatments were applied. MTT assay and flow cytometry was employed to determine cell survival. the influence of combination therapy on CD44 + CD24⁻and CD133 + CD44⁺ cell population, Comparison and evaluation of combination treatments was done respectively using Combination Indices (CIs).
Result
The final nanoparticle has a high efficiency in producing hydroxyl radicals and generating heat in MHT. According to CIs, we can conclude that combined using of light-based treatment and MHT in the presence of final synthesized nanoparticle have synergistic effect and a high ability to reduce the population of stem cells in both cell lines compared to single treatments.
Conclusion
In this study a novel multi-functional nanoplatform acted well in dual and triple combined treatments, and showed a good performance in the eradication of CSCs, in A375 and MAD-MB-231 cell lines.
... Recently, the development of biocompatible nanoparticles that have antioxidant properties has attracted a great deal of attention [10]. In addition, magnetite nanoparticles possess an intrinsic enzyme mimetic activity similar to natural peroxidase activity [11]. The peroxidase-like activity of magnetite nanoparticles is based on the coexistence of Fe 2+ /Fe 3+ ion pairing in the structure, such as Fenton's reagent, which are known to catalyze the breakdown of hydrogen peroxide [12]. ...
In recent decades, magnetite nanoparticles received greater attention in nanobiotechnology due to wide applications. This study presents the influence of the oxidative stress caused by magnetite nanoparticles coated with aspartic acid (A-MNP) of 9.17 nm mean diameter size, on maize (Zea mays) seedlings, in terms of growth, enzymatic activity and chlorophyll content as evaluated in exposed plant tissues. Diluted suspensions of colloidal magnetite nanoparticles stabilized in water were added to the culture medium of maize seeds, such as to equate nanoparticle concentrations varying from 0.55 mg/L to 11 mg/L. The obtained results showed that the growth of maize was stimulated by increasing the level of A-MNPs. Plant samples treated with different concentrations of A-MNP proved increased activities of catalase and peroxidase, and chlorophyll content, as well. The exposure of plants to magnetite nanoparticles may induce oxidative stress, which activates the plant defense/antioxidant mechanisms.
