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Schematized map illustrating the locus coeruleus (LC) and the representative expression of c-Fos like protein 24 hours after TNBS-induced inflammation of the colon. (A), schematic drawing of the locus coeruleus (B), a number of c-Fos like protein expression in each group; NOR, normal control rat (C, c); ALCO, ethanol administration (D, d); TNBS, TNBS administration (E, e). Notations are the same as the previous figures. * P 0.05, ** P 0.01.
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Objectives: Colitis is an inflammatory bowel disease characterized by colonic mucosal inflammation and chronic relapsing events represents. The purpose of this study is to evaluate effects of pharmacopuncture of anti-inflammatory herbal compound (AiC) applied to the different acupoints in the acute colitis induced by trinitrobenzenesulphonic acid (...
Citations
... Recently, it has been reported that HLT and its four typical component compounds (geniposide, baicalin, berberine and baicalein) exhibited anti inflammatory effects [25,26], and that berberine has a very broad antimicrobial spectrum [31] and anti inflammatory potential [32]. inhibited signal pathways ascending hypersensitivity of colorectum [33]. Also, Kim et al [34] reported the pharmacopuncture reduceded interleukin (IL)-2 and IL-4. ...
Purpose: Chronic nonbacterial prostatitis (CP)/chronic pelvic pain syndrome (CPPS) is known not to have a successful therapy as yet. More recently, acupuncture, some herbal compounds, and trigger point injection have been reported to be beneficial. Pharmacopuncture is an herbal acupuncture having these benefits. The aim of this study was to compare the effect of HP (Hwanglyunhaedok Pharmacopuncture) versus normal saline injection (Saline Pharmacopuncture, SP) on CP/CPPS.
Methods: A retrospective follow up study of 63 patients who were diagnosed with CP/CPPS was performed. All patients were treated with electroacupuncture and injected with either 1 ml of HP or SP at CV1 as a standard treatment for 4 weeks. Thus, the patients were classified in two groups: HP (n = 32) and SP group (n = 31). Treatment was applied twice a week every third day for 4 weeks. After 4 weeks, the effect of pharmacopunture in both groups was compared using NIH-CPSI (National Institutes of Health-Chronic Prostatitis Symptom Index) and IPSS (International Prostate Symptom Score) before and after treatment.
Results: After treatment, the total NIH-CPSI scores were significantly reduced in both groups (p
... Anti-inflammatory pharmacopuncture involves a prescription that adds drugs such as Taraxaci herba, Lonicerae flos, Rehmanniae radix, and Forsythiae fructus to a Hwangryunhaedoktang [33]. Hwangryunhaedoktang, which was mentioned in Zhouhoufang and Waitaimiyao, is ...
... In the experimental studies, anti-inflammatory pharmacopuncture was effective in suppressing colon-inflammationinduced c-Fos [33] and lipopolysaccaride-induced inflammation-related cytokines [35]. In clinical studies, anti-inflammatory pharmacopuncture was effective in treating inflammation and pain [36], as well as in treating cancer patients with accompanying pain [37] and patients with supraspinatus tendinosis and subdeltoid bursitis [38]. ...
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritic and erythematous skin lesions. The purpose of this study was to investigate the suppressive effects of anti-inflammatory and Rehmanniae radix pharmacopuncture on the development of AD-like skin lesions in NC/Nga mice. The AD was induced on the mice's back skin by using biostir AD. The experimental groups were divided into three groups, PPI (anti-inflammatory pharmacopuncture), PPII (Rehmanniae radix pharmacopuncture, hydrodistillation extraction) and PPIII (Rehmanniae radix pharmacopuncture, MeOH extraction). All mice were treated using a 1-mL syringe to inject 0.1 mL of pharmacopuncture at right and left acupoints (BL13) on alternate days. In the control group, normal saline was used instead of pharmacopuncture. The following factors were investigated: (1) optical observations made with a handscope and clinical skin scores were evaluated; (2) tissue (general/immune) mast cells and CCR3(+) eosinophils, as well as vascular endothelial growth factor, fibroblast growth factor, and epidermal growth factor immunoreactive changes were evaluated; (3) CD4(+) and CD8(+) cells in the spleen were immunohistochemically examined; and, (4) the serum immunoglobulin (Ig)E level and lymphokines [interleukin (IL)-2, IL-4] were measured. In the PPI and the PPIII groups, the clinical skin score, total number of mast cells, CCR3(+) eosinophils immunoreaction, and total serum IgE, IL-2, and IL-4 levels were lower than the control group. The PPI and the PPIII groups also showed strong immunohistochemical reactions for vascular endothelial growth factor and fibroblast growth factor. The PPI group particularly showed a very strong immunohistochemical reaction for epidermal growth factor. All groups showed strong immune activity for CD8(+). The PPIII group showed strong immunity for both CD4(+) and CD8(+). From the above results, Rehmanniae radix pharmacopuncture (MeOH extraction) and anti-inflammatory pharmacopuncture exerted anti-allergic and anti-inflammatory effects, suggesting that they are promising agents for improving AD-related symptoms.
Objectives The purpose of this study is to find out the effect of various concentrations of Hwangnyeonhaedok-tang (HTT) pharmacopuncture on ST25 (??) in rats with dextran sulfate sodium (DSS)-induced colitis.Methods Colitis was experimentally induced by feeding rats with water mixed with 5% (w/v) DSS for 20 days. The rats were divided into 5 groups: the normal group (Nor, n
