Figure 3 - uploaded by Tony Müller
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2. Schematic representation of the bone marrow transplantation procedure. (A) Experimental outline of a murine bone marrow reconstitution assay with deletion of Stat5 in the donor mice. (B) Experimental procedure of bone marrow transplantation with Stat5 deletion after bone marrow reconstitution. During this process, Stat5 should be deleted at different timepoints (2): Deletion in the donor mice before transplantation (3.2.2), deletion in the recipient animals after bone marrow reconstitution (3.2.3) and deletion after the onset of the disease (3.2.4). These experiments were conducted as a whole (3.2.2 and 3.2.3) or in part (3.2.4) by Rebekka
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Activating mutations of Fms-like tyrosine kinase 3 (FLT3) are among the most frequent alterations in acute myeloid leukemia (AML). Two distinct types of mutations have been described: internal duplication of the juxtamembraneous domain (ITD) and point mutations of the tyrosine kinase domain (TKD). Although both mutations lead to constitutive FLT3 s...
