Figure 7 - uploaded by Ellen Leich
Content may be subject to copyright.
Schematic presentation of the V-D-J-region of a IgH gene locus and the aligned primer combinations FR3-LJH and FR2-LJH/VLJH that were used for
Source publication
Neoplasien des hämatopoetischen und lymphoiden Systems können in Hodkin Lymphome und in Non-Hodgkin Lymphome (NHL) unterteilt werden. Etwa 80% der NHL sind B-Zell Lymphome (B-NHL), während etwa 20% T-Zell und NK-Zell Lymphome (T-NHL) umfassen. Genetische Alterationen, insbesondere Translokationen, welche die Immunglobulin (Ig) Rezeptor Gene betreff...
Similar publications
In the evolution of many organisms, periods of slow genome reorganization (= chromosomal conservatism) are interrupted by bursts of numerous chromosomal changes (= chromosomal megaevolution). Using comparative analysis of chromosome-level genome assemblies, we investigated these processes in blue butterflies (Lycaenidae). We demonstrate that the ph...
Most recent initiatives to sequence and assemble new species' genomes de-novo fail to achieve the ultimate endpoint to produce contigs, each representing one whole chromosome. Even the best-assembled genomes (using contemporary technologies) consist of sub-chromosomal sized scaffolds. To circumvent this problem, we developed a novel approach that c...
Copy number variants (CNVs) are a class of structural variants that may involve complex genomic rearrangements (CGRs) and that are hypothesized to have additional mutations around their breakpoints. Understanding the mechanisms underlying CNV formation is fundamental for understanding the repair and mutation mechanisms in cells, thereby shedding li...
The role of chromosome rearrangements in driving evolution has been a long-standing question of evolutionary biology. Here we focused on ruminants as a model to assess how rearrangements may have contributed to the evolution of gene regulation. Using reconstructed ancestral karyotypes of Cetartiodactyls, Ruminants, Pecorans, and Bovids, we traced p...
Chromosome translocations are well-established hallmarks of cancer cells and often occur at nonrandom sites in the genome. The molecular features that define recurrent chromosome breakpoints are largely unknown. Using a combination of bioinformatics, biochemical analysis, and cell-based assays, we indentify here specific histone modifications as fa...
