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Schematic of the geometry of a simple carotid.

Schematic of the geometry of a simple carotid.

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Figure 2. Schematic of the geometry of a simple carotid.
Figure 3. Computer ltration velocity across the wall based on diierent...
Figure 4. Computed dimensionless LDL concentration proole across...
Figure 5. Computed average dimensionless LDL concentration proole...
+7 Figure 5 illustrates average dimensionless LDL concentration. It can be...
Effects of hypertension on Intima-Media Thickness (IMT); application to a human carotid artery
Article
Full-text available
  • Sep 2016
A vast number of deaths in the world have been attributed to atherosclerosis. The prominent aim of this study is proposing an accurate and simple model to investigate the process of arterial wall thickening. In order to investigate LDL (Low Density Lipoprotein) accumulation in arterial wall, a four layer model for arterial wall consisting of endoth...
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Context 1
... geometry of the three dimensional model for carotid bifurcation, shown in Figure 2, was derived from Gijsen et al. [13]. A parabolic velocity proole was prescribed at the inlet in which the Re number was speciied 270. ...
Context 2
... horizontal plane, dividing the geometry into two identical parts, is used to depict mass transport more precisely. The mentioned plane has the same shape as Figure 2. LDL concentration along non- divider walls are shown in Figures 11 and 12. ...

Citations

... Specifi cally, the intimal hyperplasia which is the "migration" result of Smooth Muscle Cells (SMCs) from media to intima, (the hypertension gives a further boost to that process [26]) incorporates LDL transportation and accumulation. In recent computational studies, the process of plaque formation is modeled assuming LDL oxidation modeling and intima-media thickness analysis [34]. Current results indicate that the LDL at the endothelium/intima interface is substantially lower, almost 90 times, than its value at lumen/endothelium interface. ...
Unsteady LDL Transport through Patient-Specific Multi-Layer Left Coronary Artery. Int J Clin Cardiol Res. 2018;2(2): 039-049
Research
Full-text available
  • Sep 2018
Aims: The objective of the study is to study the transport and distribution of Low Density Lipoprotein (LDL) within patient-specifi c multi-layer arterial wall model under unsteady fl ow using computational fl uid dynamic analysis. Methods: A Left Coronary Artery (LCA) patient-specifi c model was incorporated. Both fl ow-mass transport equations in lumen as well as fl ow-mass transport equations within the patient-specifi c multi-layer arterial wall are numerically analyzed. Results: The lumen-side LDL concentration preferably occurs at the concave geometry parts denoting concentration polarization. The Average Wall Shear Stress (AWSS) is not the only factor that can determine the lumen-side concentration of LDL. Increased time- averaged luminal concentration develops mainly in the proximal rather than to distal segment fl ow parts. The LDL concentration at the endothelium/intima interface is substantially lower, almost 90 times, than its value at lumen/endothelium interface. The concentration drop across the intima layer is negligible, whereas the concentration reduction across the Internal Elastic Layer (IEL) is remarkable. LDL concentration values at the IEL/media interface are one order of magnitude smaller to ones occurring at the intima layer. Conclusions: The transportation of LDL through the multi-layer arterial wall is affected by the fl ow pattern itself, the arterial wall thickness and the physical values of the layers.
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