Schematic illustration of the human midbrain displaying VTA nuclei. The localizations of the nuclei are approximately displayed by using the Atlas of the Human Brainstem by Paxinos and Huang as reference. Aq: aquaduct; IF: nucleus interfascicularis; LC: nucleus linearis caudalis/centralis; LR: nucleus linearis rostralis; PAG: periaquductal gray; PN: nucleus paranigralis; PBP: nucleus parabrachialis pigmentosus; RN: red nucleus; SN: substantia nigra. Illustration design: Esat Ad›güzel; digitalization: C. Gökçen Köseli. [Color figure can be viewed in the online issue, which is available at www.anatomy.org.tr]

Schematic illustration of the human midbrain displaying VTA nuclei. The localizations of the nuclei are approximately displayed by using the Atlas of the Human Brainstem by Paxinos and Huang as reference. Aq: aquaduct; IF: nucleus interfascicularis; LC: nucleus linearis caudalis/centralis; LR: nucleus linearis rostralis; PAG: periaquductal gray; PN: nucleus paranigralis; PBP: nucleus parabrachialis pigmentosus; RN: red nucleus; SN: substantia nigra. Illustration design: Esat Ad›güzel; digitalization: C. Gökçen Köseli. [Color figure can be viewed in the online issue, which is available at www.anatomy.org.tr]

Contexts in source publication

Context 1
... Nissl stained sections, neurons of VTA were distinguishable from the red nucleus dorsally, and separated from the interpeduncular nucleus ventrally. [25,26] However, this adjacency of these structures shows differences in the sections of midbrain from caudal to rostral (Figure 1). In terms of ease of understanding, the local- ization of these structures were discussed by using the Atlas of the Human Brainstem by Paxinos and Huang that takes obex as a reference point. ...
Context 2
... respectively. LR and PBP continue from obex up to 47 mm rostral [27] (Figure 1). IF is located in the midline, LR and LC are in the paramedian zone, and others (PN, PBP) are located more laterally in humans. ...

Citations

Article
Over time, the body undergoes a natural, multifactorial, and ongoing process named senescence, which induces changes at the molecular, cellular, and micro-anatomical levels in many body systems. The brain, being a highly complex organ, is particularly affected by this process, potentially impairing its numerous functions. The brain relies on chemical messengers known as neurotransmitters to function properly, with dopamine being one of the most crucial. This catecholamine is responsible for a broad range of critical roles in the central nervous system, including movement, learning, cognition, motivation, emotion, reward, hormonal release, memory consolidation, visual performance, sexual drive, modulation of circadian rhythms, and brain development. In this comprehensive review, we thoroughly examine the impact of senescence on the dopaminergic system, with a primary focus on the classic delimitations of the dopaminergic nuclei from A8 to A17. We provide in-depth information about their anatomy and function, particularly addressing how senescence affects each of these nuclei.