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Purpose:
To date, invasive urodynamic investigations have been used to define most terms and conditions relating to lower urinary tract symptoms. This invasiveness is almost totally due to the urethral catheter. In order to remove this source of discomfort for patients, the present study investigated a noninvasive methodology able to provide diagn...
Contexts in source publication
Context 1
... model ( Fig. 1), assembled and set up in the Bio-fluid-dynamic Laboratory of Department of Civil and Environmental Engineering of the university of our city, consists of a 2-m-tall cylindrical Plexiglas tank filled with water to reproduce human bladder pressure. At the bottom, a hole for drainage is connected to a collapsible elastic latex Penrose ...
Context 2
... water level in the tank, expressed in terms of centimeters of water column (cm H2O), represents the pressure at the upstream end of the elastic tube, thus simulating the bladder pressure (P0) (Fig. 1). This value is intended to include detrusor and abdominal ...
Context 3
... Fig. 10, a comparison between the present study and a pressure-flow study in 7 healthy men is presented. The same color represents the same person. Despite the low number of available pressure-flow studies, it can be seen that most of the results were consistent, while only 1 (cyan) was a false ...
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Citations
... 25 This model estimated the probability of DU in clinical practice without an invasive PFS: older age, smaller prostate volume, less urgency, weak stream and a lower Qmax were selected as five independent predictive factors of DU. 25 Lotti et al. investigated a noninvasive method able to distinguish between BOO and DU by the simultaneous measurements of flow rate and jet exit velocity strictly associated with bladder pressure, using a new experimental diagram. 26 A recent consensus group of the Japanese Continence Society produced diagnostic criteria to potentially identify patients likely to have DU, without a PFS-based diagnosis. 27 Some symptoms and several noninvasive test parameters were used as clinical predictors of DU and were suggested to discriminate DU from BOO: (1) symptom complex of UAB (in particular, voiding symptoms of slow stream, hesitancy and straining to void, and often reduced sensation of filling), (2) maximum flow rate <12 mL/s, PVR urine volume >100 mL, (3) bladder voiding efficiency < 90%, (4) for men-intravesical prostatic protrusion < 10 mm and/or prostate volume < 30 mL, and women-absence of significant pelvic organ prolapse (cystocele with equal to and less than grade II). ...
Introduction
Overactive bladder (OAB) and underactive bladder (UAB) could be associated with metabolic syndrome, affective disorders, sex hormone deficiency, changes in urinary microbiota, functional gastrointestinal disorders, or autonomic nervous system dysfunction.
Objectives
The aim of this Think Tank was to provide a guide on how to investigate OAB and/or detrusor underactivity (DU) patients to better clarify the underlying pathophysiology and possibly personalize the treatment.
Methods
A compendium of discussion based on the current evidence related to phenotyping patients with OAB or DU using urodynamic tests, functional neuro‐imaging, urinary markers, and microbiome.
Results and Conclusions
The article emphasizes the critical significance of adopting a comprehensive yet tailored approach to phenotyping patients with lower urinary tract (LUT) symptoms, such as OAB and UAB. The intricate interplay between the LUT and various factors, metabolic, neurological, psychological, and gastrointestinal can define unique LUT profiles, enabling personalized therapies to replace the one‐size‐fits‐all approach.
