Figure 1 - uploaded by Yudha Nurhantari
Content may be subject to copyright.
Schematic determination of allele gene ADH3*1/3*2
Source publication
Indonesian culture actually has no historical record of behaviors in consuming alcohol, but there are many recent reports of alcohol abuse among Asian people involving their traditional drink. In genotype studies, the damage of the liver caused by consuming alcohol is influenced by the presence of the polymorphism enzyme gene. The lack of study reg...
Citations
... Alcohol intake influences liver function as it is majorly involved in metabolizing the alcohol consumed. Previous studies have correlated genetic polymorphisms that affect alcohol metabolism including ALDH, ADH [31] with Gamma Glutamyl Transferase (GGT) levels. Polymorphisms of other neurotransmitter systems like dopamine have also been reported to have an effect on the liver enzymes. ...
... On correlation with liver function enzymes' status, this polymorphism was found to be significantly associated with raised SGPT levels (p=0.036). Previous study by Suhartini et al. [31] explains that presence of polymorphism in the genes of Aldehyde dehydrogenase might affect the function of liver as suggested by raised gamma glutamyl transferase (GGT) levels in the subjects having the variant genotype. Gene polymorphisms may be associated with certain disorders due to their direct/indirect effect on the rate of transcription and levels of the proteins synthesized as seen in liver dysfunction due to presence of certain SNP's. ...
... The demand for Balinese wine nowadays is quite a lot for consumption for the surrounding community and also the Balinese people in general. In addition, along with the development of tourism, there are also many requests from foreign tourists to consume Arak Bali as a traditional alcoholic beverage and typical of Bali, such as other alcoholic beverages in hotels Five star, such as Wine, Vodka, Beer, Cider, and rum, Brandy, Tequila, Whisky, Moonshine, and Alcopops (Suhartini et al., 2016;Gepu et al., 2018;Wisudawati & Maheswari, 2018). ...
Arak Bali is a traditional Balinese alcoholic beverage that is still popular in this modern era. Balinese people are already very familiar with this type of alcoholic drink, especially those who are young or who have religious ceremonies. Arak Bali is widely produced in Sidemen village, Karangasem Regency. This study applies a descriptive qualitative research method. The data were collected through participating observation, interviews with the community in Sidemen village as well as a literature study of Arak Bali. The study found, so far Arak needs have been widespread, from the religious need to commodify into the needs of tourism, especially in bars and restaurants. The Arak cocktail has become a spirit in beverage blends, which can be found in the bars and restaurants in Bali. Therefore, this type of beverage is still an item that has high value in the economic sector as well as support for the life of farmers in Sidemen village. This condition makes farmers in the village of Sidemen to consistently produce wine and retain their legacy.
... Two alcohol dehydrogenase family genes, ADH1B and ADH1C, linked with liver cirrhosis (Fig. 4B). Suhartini et al. reported that ADH3 (alcohol dehydrogenase 3) could influence the status of liver function (Suhartini et al., 2017). Moreover, ALDH2, F7 and IL2 were reported to relate with cancer and liver diseases (Jounaidi et al., 2017;Matsumoto et al., 2016). ...
... Alcohol intake influences liver function as it is majorly involved in metabolizing the alcohol consumed. Previous studies have correlated genetic polymorphisms that affect alcohol metabolism including ALDH, ADH [31] with Gamma Glutamyl Transferase (GGT) levels. Polymorphisms of other neurotransmitter systems like dopamine have also been reported to have an effect on the liver enzymes. ...
... On correlation with liver function enzymes' status, this polymorphism was found to be significantly associated with raised SGPT levels (p=0.036). Previous study by Suhartini et al. [31] explains that presence of polymorphism in the genes of Aldehyde dehydrogenase might affect the function of liver as suggested by raised gamma glutamyl transferase (GGT) levels in the subjects having the variant genotype. Gene polymorphisms may be associated with certain disorders due to their direct/indirect effect on the rate of transcription and levels of the proteins synthesized as seen in liver dysfunction due to presence of certain SNP's. ...
Alcohol dependence (AD), associated with high mortality and morbidity is caused due to involvement of both environmental and genetic factors. Behavioral effects of alcohol including cognitive impairment, motor incoordination, tolerance and dependence are likely due to its effect on the multiple brain proteins including neurotransmitters. Dysfunction in these neurotransmitter systems may be at the level of enzymes involved in metabolic degradation, or receptors involved in neurotransmission like dopamine, Gamma-amino butyric acid (GABA), serotonin etc. Genetic polymorphisms in these neurotransmitter systems are implicated in conferring susceptibility to AD. Aim: To identify association of single nucleotide polymorphisms (SNPs) in COMT (rs4680 and rs2075507) and GABAA receptor genes (rs13172914 and rs211014) with AD. Method: A total of 100 AD patients diagnosed on the basis of DSM IV criteria from the outpatient clinic of the National Drug Dependence Treatment Centre (NDDTC) of All India Institute of Medical Sciences (AIIMS), and 100 healthy individuals from the general population were recruited. A detailed history including pattern of drug use and demographic details with pedigree information was noted. Genomic DNA from peripheral blood samples was processed for PCR amplification followed by restriction digestion to screen for the presence of polymorphisms. Genotype and allele frequencies were evaluated and correlated with alcohol use parameters including duration of alcohol use, age at onset of alcohol use, quantity of alcohol consumed (gms/day) and WHO ASSIST score and levels of liver function enzymes (SGPT and SGOT). Statistical analysis was performed using SPSS v21.0. Results: Genetic analysis of the study group revealed COMT rs4680 to be significantly associated with AD (p=0.03), while the other COMT SNP rs2075507 showed an association with increased levels of SGPT in the patients. GABAA receptor gene polymorphisms showed no association with AD. Conclusion: The study suggests a role of COMT gene polymorphism rs4680 in conferring susceptibility to AD.
