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Acupuncture point application therapies, including San-Fu-Tie and San-Fu-Jiu, have been widely employed to treat diseases with attacks in winter during dog days in China. The therapies combine Chinese herbal medicine and acupuncture points with the nature. However, the previous studies were reported to be unsystematic and incomplete. To develop a m...
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Abstract Background Allergic rhinitis is a common respiratory disease. Acupuncture is used to treat it in traditional Chinese medicine, and generally, the L120, ST2 and ST36 acupoints are selected in clinical practice. We report a new method of acupuncture at the sphenopalatine acupoint (SPA) for treatment of persistent allergic rhinitis (PAR). The...
Background
Allergic rhinitis (AR) is one of the most common allergic diseases. The conventional treatments of allergic rhinitis are oral anti-histamines, the use of intranasal corticosteroids, and immunotherapy. Dissatisfied with the ineffectiveness and side effects of these treatments, substantial numbers of patients are turning to alternative tre...
Background
Allergic rhinitis is regarded as an imbalanced Th1/Th2 cell-mediated response. The present study used microarray analysis to compare gene expression levels between allergic rhinitis patients before and after a series of acupoint herbal plaster applications. Methods
In this experimental pilot study, volunteers experiencing sneezing, runny...
Citations
... Under the overall action of acupoints, meridians and drugs, it enters from the outside to the inside, and regulates the Zang-Fu organs by means of the meridian tropism of drugs (5). Its direct approach, rapid onset, low recurrence rate and simple and safe personalized diagnosis and treatment are more prominent advantages in clinical treatment (6,7). The Graphene-based warm uterus acupoint paste (GWUAP) used in this experiment is a new generation product that combines traditional acupoint application materials containing traditional Chinese medicine ingredients with 1 ‰ graphene by using supercritical CO 2 extraction technology and microcapsule production process. ...
Graphene-based warm uterus acupoint paste (GWUAP) is an emerging non-drug alternative therapy for the treatment of primary dysmenorrhea (PD), but the underlying mechanism is still unclear. SD female rats were randomly divided into control group, model group and treatment group to explore the mechanism of GWUAP in the treatment of PD. Combined with 16S rDNA and fecal metabolomics, the diversity of microbiota and metabolites in each group was comprehensively evaluated. In this study, GWUAP reduced the torsion score of PD model rats, improved the pathological morphology of uterine tissue, reduced the pathological damage score of uterine tissue, and reversed the expression levels of inflammatory factors, pain factors and sex hormones. The 16 S rDNA sequencing of fecal samples showed that the abundance of Lactobacillus in the intestinal flora of the model group decreased and the abundance of Romboutsia increased, while the abundance of Lactobacillus in the intestinal flora of the treatment group increased and the abundance of Romboutsia decreased, which improved the imbalance of flora diversity in PD rats. In addition, 32 metabolites related to therapeutic effects were identified by metabolomics of fecal samples. Moreover, there is a close correlation between fecal microbiota and metabolites. Therefore, the mechanism of GWUAP in the treatment of PD remains to be further studied.
... [13] Indeed, the AAT approach has been applied to treat severe chronic and allergic diseases. [14][15][16] For example, the basic drugs in the prescription for AAT in summer to treat the pulmonary diseases attacking in winter include Rhizoma Corydalis, Semen Sinapis Albae, Radix Euphorbiae Kansui, and Herba Asari. [13,17] Semen Sinapis Albae is pungent and hot in nature and has the effects of warming the lung, resolving phlegm, eliminating swelling, unblocking the ligaments, and relieving pain, while Herba Asari, is pungent in taste and warm in nature, which could warm the lung, dissolve phlegm, dispel wind, and disperse cold. ...
... [19,23,24] In the Chinese medical system, a season-based AAT approach has also been applied to improve or prevent recurrent seasonal diseases. [25] The summer acupoint application treatment (SAAT, also known as "Sanfujiu") is a way in which herbal compounds are applied in summer at special points (generally in dog days) to prevent active periods or modify diseases attacking in winter, including bronchial asthma, [11] allergic rhinitis, [14,26] and chronic obstructive pulmonary disease, [16] and so forth, [12] and SAAT has been widely used in many provinces in China since the 1950s. [13] A 2-year follow-up study revealed that SAAT on the BL13 and BL12 (Fengmen) acupoints could reduce the frequency and severity of asthma [27] and SSAT is efficacious in treating seasonal Allergic rhinitis and the treatment efficiency was positively correlated with the length of treatment course. ...
Acupoint application has served as an important complementary and adjunctive therapy in China. The purpose of this study is to explore the impact of summer acupoint application treatment (SAAT) on the abundance and biological structure of gut microbiota in healthy Asian adults. Based on the CONSORT guidelines, 72 healthy adults were included in this study, randomly divided into 2 groups, receiving either traditional (acupoint application within known relevant meridians, Group A) or sham (treated with placebo prepared by mixing the equal amount of starch and water, Group B) SAAT. SAAT stickers include extracts from Rhizoma Corydalis, Sinapis alba, Euphorbia kansui, Asari Herba, and the treatment group received 3 sessions of SAAT for 24 months, administered to BL13 (Feishu), BL17 (Geshu), BL20 (Pishu), and BL23 (Shenshu) acupoints. Fecal microbial analyses via ribosomal ribonucleic acid (rRNA) sequencing were performed on donor stool samples before and after 2 years of SAAT or placebo treatment to analyze the abundances, diversity, and structure of gut microbiota. No significant baseline differences were present between groups. At the phylum level, the baseline relative abundance of Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, and Fusobacteria was identified in fecal samples collected from each group. After treatment, the relative abundance of Firmicutes was significantly increased in both groups (P < .05). Notably, a significant decrease in the relative abundance of Fusobacteria was observed in the SAAT treatment group (P < .001), while the abundance of Bacteroidetes was decreased significantly in the placebo group (P < .05). At the genus level, the relative abundance of Faecalibacterium and Subdoligranulum species in the 2 groups were all significantly increased (P < .05). In addition, a significant reduction in the relative abundance of Blautia, Bacteroides, and Dorea in Group A (P < .05) and Eubacterium hallii group and Anaerostipes (P < .05) in Group B was observed after treatment. Our findings indicated SAAT substantially influenced the bacterial community structure in the gut microbiota of healthy Asian adults, which might serve as potential therapeutic targets for related diseases, and provided a foundation for future studies aimed at elucidating the microbial mechanisms underlying SAAT for the treatment of various conditions such as obesity, insulin resistance, irritable bowel syndrome.
... Pada telaah sistematis dari jurnal-jurnal yang berhubungan dengan kondisi klinis asma dan rinitis alergi, didapatkan hasil bahwa frekuensi titik akupunktur yang banyak dipilih untuk terapi asma adalah BL13, GV14, EX-B1, BL23 dan BL20. (Wen et al., 2015) Titik EX-B1 sangat baik dan diindikasikan untuk asma, batuk, terutama Bersama dengan titik BL13 yang juga sering dipakai untuk indikasi batuk, asma. Titik BL13 dan EX-B1 pada asma bronkial secara segmental bekerja melalui mekanisme jalur aferen otonom dari refleks viseral somatik dan relaksasi otot polos bronkus melalui sistem saraf otonom hingga akhirnya terjadi dilatasi bronkus, ditunjang oleh bukti penelitian dari Jepang memperlihatkan bahwa pasien asma yang diterapi dengan akupunktur di titik-titik tersebut menunjukkan efek sistemik(sentral-segmental), sedasi dan relaksasi dari kontraksi otot polos bronkus selama satu jam setelah akupunktur, sehingga terjadi penurunan resistensi pernapasan. ...
Asthma is a chronic inflammatory disorder of the respiratory tract where many cells and cellular elements play a role, especially eosinophils, IgE, and other components. Uncontrolled asthma causes the quality of the patient's life to decline. Acupuncture is one of the complementary therapies that are scientifically proven to help cure asthma. Many studies have proven that acupuncture plays a role in the anti-inflammatory process. In this case report, we used the acupuncture method of thread embedding penetration from point EX-B1 to BL13, LI11, ST36, and BL23 on both sides. Acupuncture therapy is done once when the patient first arrives. The results after 3 months observations showed that patients experienced an improvement in eosinophil count, decreased level of IgE, and increased Asthma Control Test values. The improvement showed patients were fully controlled in the first month until the end of the evaluation. Therefore, thread embedding could be a good, safe, and effective treatment for asthma in adults.
Keywords: asthma, thread embedding acupuncture, anti-inflammation
... In the recent past, an increasing number and size of random controlled trials (RCTs) for AR have been conducted with several systematic reviews [20,21,[30][31][32][33], confirming the efficacy and safety of acupuncture. However, these studies have only focused on a single acupuncture therapy against a control treatment for AR. ...
Background
Allergic rhinitis (AR) is a common symptomatic, inflammatory, and immunological disorder of nasal mucosa. Multiple clinical trials and systematic reviews have implicated acupuncture methods as potentially effective treatment strategies for AR, however, considering the great burden of AR, it is crucial to explore the most recent clinical evidence supporting acupuncture in AR. Besides, the methodologies reported in previous studies as well as those commonly applied during clinical practices greatly vary. Herein, we conducted network meta-analysis to compare the effectiveness of diverse acupuncture methods for AR treatment.
Methods
We conducted a literature search for relevant reports published from inception to 1 July 2020 in several scientific databases, including PubMed, Embase, Cochrane library, Web of Science, CNKI, WF, VIP, CBM, AMED as well as related registration platforms. Primary outcomes as reported in the identified studies were assessed using nasal symptoms. All Meta-analyses were performed with RevMan, ADDIS, and STATA software. To ensure consistency among our reviewers, the intra-class correlation coefficient was used.
Results
Exactly 39 studies with 3433 participants were covered in this meta-analysis. The meta-analysis demonstrated that all acupuncture types were superior to sham acupuncture in terms of total nasal symptom score and rhinoconjunctivitis quality of life questionnaire. Moxibustion was recommended as the most effective intervention as it reduced nasal symptoms in 6 treatments. On the other hand, manual acupuncture plus conventional medicine was recommended as the most effective intervention in improving the quality of life in 9 treatments. Notably, moxibustion was recommended as the most effective intervention that changed the content of IgE in 9 treatments. Moreover, adverse events of these interventions were acceptable.
Conclusion
Our findings revealed that all acupuncture methods are effective and safe for AR. Moreover, either moxibustion or manual acupuncture plus conventional medicine are potentially the most effective treatment strategies for AR. Based on these findings, it is evident that acupuncture therapy is not inferior to pharmacologic therapy. Therefore, for AR patients who are either unresponsive to conventional medicine or are intolerant to adverse events, acupuncture therapy should be administered. However, the quality of these included trials was mainly ranked as moderate quality, we recommend additional well-designed RCTs with larger sample sizes to validate these findings.
... 195,196 Acupuncture and herbal moxibustion* Traditional Chinese medicine uses these approaches presumably interfering with the energetic state of the nasal tissues to improve symptoms and HRQoL of rhinitis sufferers and reduce the recurrence of exacerbation episodes. [197][198][199][200] Devices for anaphylaxis management Anaphylaxis is a severe generalized hypersensitivity reaction that is rapid in onset and may cause death. Anaphylaxis management is mainly based on preventing a reaction and treating each anaphylactic episode. ...
Medical devices provide people with some health benefits in terms of diagnosis, prevention, treatment, and monitoring of disease processes. Different medical specialties use varieties of medical devices more or less specific for them. Allergology is an interdisciplinary field of medical science and teaches that allergic reactions are of systemic nature but can express themselves at the level of different organs across the life cycle of an individual. Subsequently, medical devices used in allergology could be regarded as: 1) general, servicing the integral diagnostic and management principles and features of allergology, and 2) organ specific, which are shared by organ specific disciplines like pulmonology, otorhinolaryngology, dermatology, and others. The present position paper of the World Allergy Organization (WAO) is meant to be the first integral document providing structured information on medical devices in allergology used in daily routine but also needed for sophisticated diagnostic purposes and modern disease management. It is supposed to contribute to the transformation of the health care system into integrated care pathways for interrelated comorbidities.
... P < 0.00001; I(2) = 18%). The treatment group exhibited a more conspicuous decline in IgE level (standard mean difference [SMD], − 1.40; 95% CI, − 2.18 to − 0.63; P = 0.0004; I(2) = 85%) and eosinophil (Eos) count (SMD, − 4.26; 95% CI, − 6.28 to − 2.23; P < 0.00001; I(2) = 91%) compared with the control group [101,102]. ...
Purpose of review:
This paper purports to review recent relevant publications on the efficacy of traditional Chinese medicine in treating allergic diseases, to illustrate the pertinent mechanisms of action of TCM, and to explore the possible role of TCM in the management of allergic diseases in the foreseeable future. As TCM embodies multiple treatment modalities, only the most popular two, namely CHM (Chinese herbal medicine) and acupuncture, were discussed. Publications, especially reviews involving randomized controlled trials (RCTs) on the use of TCM on allergic diseases, published up to June 2019 were reviewed and analyzed. Papers reporting the mechanisms of action of TCM in allergic diseases were also included. Other publications in Chinese were also discussed.
Recent findings:
A startling escalation in the incidence of allergic diseases in the last several decades has posed tremendous social and financial burdens on the community. Failing to locate a cure for these chronic diseases, patients have resorted to using alternative medications of which traditional Chinese medicine (TCM) is a popular one. Thus CHM has been extensively employed for treating allergic diseases. Some investigations have been conducted to ascertain the therapeutic efficacy of CHM for allergic diseases. Although CHM has been widely deployed for treating allergic diseases, it appears from the published data that there is a dearth of conclusive evidence to establish the effectiveness of CHM for allergic diseases. It is recommended that more large- scale RCTs with prolonged durations be carried out to corroborate the efficacy of CHM for allergic diseases. On the other hand, there is ample evidence indicating that acupuncture is useful when administered alone in allergic rhinitis and asthma or when applied as an adjunct to conventional western therapy. Evidence of its utility in atopic eczema and urticaria is not definitive. It is recommended that acupuncture be integrated into the therapy of allergic rhinitis and asthma, and that CHM be used as an adjunct in the treatment of allergic diseases on an individual basis.
... RHAS is an effective traditional Chinese medicine treatment, carried out in the summer to relieve the recurrence of allergic asthma that has been used in China for hundreds of years. Wen et al. [9] evaluated 18 studies involving 1785 subjects conducted before 2015 and indicated that RHAS had been widely and successfully used for the treatment of allergic asthma. Wu et al. [10] studied the RHAS treatment of allergic asthma patients for two consecutive years; the frequency and severity of allergic asthma recurrence reduced, and the number of medications used also decreased significantly. ...
Allergic asthma is an inflammatory disease involving the Th1/Th2 cell imbalance in the peripheral blood. Repeated herbal acupoint sticking (RHAS) has been used for hundreds of years in China to relieve the recurrence of allergic asthma, and it is still practiced today. Thus, we explored the effect on allergic asthma relapse and the underlying immunoregulatory mechanism in this study. Here, we enrolled 50 allergic asthma participants, and 38 of them completed the treatment and follow-up (the allergic asthma group). In addition, 13 healthy participants (the control group) were enrolled. The recurrence number of allergic asthma participants and asthma control test (ACT) were used to evaluate the effect of treatment on relieving allergic asthma recurrence. Flow cytometry was performed to analyze the levels of Th1 and Th2 cells in the peripheral blood. The serum levels of IgE, IFN-γ, and IL-4 were detected by ELISA. (1) In the allergic asthma group, compared to before the first treatment, the recurrence number of allergic asthma participants decreased and the ACT score increased at end of the last treatment, 18 and 30 weeks of the trial (P
... Previous clinical studies have shown that acupuncture or herbal moxibustion alone could improve AR symptoms, reduce the recurrence rate, and improve the quality of life [17][18][19][20]. A systematic review involving 13 studies has reported in 2015 that acupuncture could decrease nasal symptom scores, medication scores, and serum IgE level [18]. ...
... A systematic review involving 13 studies has reported in 2015 that acupuncture could decrease nasal symptom scores, medication scores, and serum IgE level [18]. Acupoint herbal patching alone or combined with Western medicine was also found to be more effective than placebo or Western medicine on improving total clinical symptoms and signs and quality of life in a systematic review including 20 RCTs [19,20]. However, the quality of some previous clinical studies was generally low, and there is still no sound evidence to establish the effect of herbal moxibustion with acupuncture on AR [21,22]. ...
Background:
Allergic rhinitis (AR) is a common disease. No evidence is available for the clinical application of acupuncture and moxibustion for the management of AR symptoms in Hong Kong. This study aimed to evaluate the clinical effectiveness of acupuncture with or without herbal moxibustion on relieving AR symptoms in the Hong Kong population.
Methods:
A single-centre, randomized, assessor-blinded, controlled trial with three parallel arms (acupuncture alone, acupuncture combined with herbal moxibustion treatment and waitlist) was designed. Groups with acupuncture treatment received treatment 3 times per week for a total of 12 sessions in 4 weeks. Acupuncture combined with herbal moxibustion treatment group received herbal moxibustion once per week for a total of 4 sessions over 4 weeks in addition to acupuncture treatment. Participants in the waitlist group received no treatment. All patients received advice on healthy lifestyle, diet, and exercise.
Results:
Ninety-six subjects were recruited and allocated randomly (1:1:1) into three study groups. Compared to the waitlist group, both treatment groups demonstrated statistically significant decreases in TNSS and RQLQ at the end of treatment as well as after follow-up period (all P < 0.01). However, there was no statistically differences between these two treatment groups. There was no difference in the change of total IgE levels among study groups before or after the treatment. Only one patient reported adverse effects with herbal moxibustion treatment, and no adverse effects were found in others.
Conclusions:
This study supports that acupuncture could help relieve AR symptoms, but no evidence on additional treatment effect of herbal moxibustion was found.Trial registration ChiCTR-INR-16010047 registered on November 25, 2016.
... [15][16][17] Therefore, many patients choose Chinese medicines, with relatively few side effects, to treat asthma. Traditional Chinese medicine (including Chinese medicines, [18,19] acupuncture, [20] massage, acupoint sticking therapy, [21] acupoint catgut embedding therapy, [22] diet therapy, [23] and other physical interventions) is widely applied for asthma. ...
Background:
Asthma is a complex disease associated with many factors such as immunologic, environmental, genetic, and other factors. Common medicines used to treat asthma include β-agonist and glucocorticoid. However, in the long-term treatment, the effect of the above-mentioned drugs is not satisfactory, so many patients choose oral Chinese medicines instead of western medicines. The introduction of Chinese medicines therapies, a rapid proliferation of the literature on management of asthma in general, call for novel ways of evidence synthesis in this area. This systematic review is to systematically summarize and evaluate a large number of evidences for Chinese herbal interventions for asthma. Evaluate the efficacy and safety of Chinese medicines in the treatment of asthma and inform a decision aid for the clinical encounter between patients and clinicians. In addition, it helps to establish a future research agenda.
Methods:
Five English databases (PubMed, Web of science, EBASE, Springer Cochrane Library, and WHO International Clinical Trials Registry Platform) and 4 Chinese databases (Wanfang Database, Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, and Chinese Biomedical Literature Database) will be searched normatively according to the rule of each database from the inception to the present. The literature screening, data extraction, and quality assessment will be conducted by 2 researchers independently. Data will be synthesized by either the fixed-effects or random-effects model according to a heterogeneity test. Asthma control test symptom score will be assessed as the primary outcome. The curative effect of single symptom and sign; Withdrawal and reduction of western medicines in a course of treatment, including: time, type, and quantity; Maintenance of western medicines after the course of treatment, including: type, quantity; Asthma Quality of Life Questionnaire; laboratory efficacy indexes as the secondary outcome. General physical examination; routine examination of blood, urine, and stool; electrocardiogram; liver and kidney function examination; possible adverse reactions and related detection indicators as the security indexes. Meta-analysis will be performed using RevMan5.3.5 software provided by the Cochrane Collaboration.
Results:
This study will provide high-quality synthesis based on current evidence of Chinese medicines treatment for asthma in several aspects, including asthma control score, side effects and laboratory examination such as lung-function test, serum total immunoglobulin, and so on.
Conclusion:
The results of this study will provide updated evidence for whether Chinese medicines is an effective and safe intervention for asthma.
Prospero registration number:
PROSPERO CRD42019136074.
... The therapies combine Chinese herbal medicine and acupuncture points with the nature. 15 The drug is irritating to the skin, with the efficacy of warming collateral channels, dispersing cold, activating collaterals and relieving pain, which will regulate the body's Yin and Yang balance, enhancing the body's ability to prevent disease. In addition, the method is simple, easy to operate and has no side effects. ...
Objective:
To evaluate the efficacy and safety of stimulating acupoints in subjects with childhood cough variant asthma (CVA).
Methods:
A Meta-analysis of randomized controlled trials (RCTs) about the comparison between acupoint sticking therapy and non-acupoint sticking therapy for childhood CVA was conducted. The trials' quality and risk bias were assessed using the Cochrane Handbook tool. Odds ratio (OR) or risk ratio (RR) with 95% confidence intervals (CIs), mean differences (MDs) or standardized mean differences (SMDs) of a random-effects model were calculated. Heterogeneity was assessed by P value and I 2 statistics.
Results:
Thirteen studies were included in our review, indicating that the total effective rate of stimulating-acupoint group is better than that of control group [RR 1.19, 95% CI (1.13-1.26), P < 0.000 01]. The recurrence rate in two years [RR 0.31, 95% CI (0.19-0.51), P < 0.000 01] and cough duration [MD = -2.42, 95% CI (-3.75, -1.09), P = 0.0004] of childhood CVA in stimulating-acupoint group were significantly lower than those in control group. Besides, stimulating acupoints can reduce the level of IgE [SMD = -0.75, 95% CI (-1.21,-0.30), P = 0.001] and EOS [SMD = -0.36, 95% CI (-0.92, 0.21), P = 0.22].
Conclusion:
Our findings suggest that stimulating acupoints had positive effects on childhood CVA and was relatively safe treatment. However, more RCTs with more useful indicators are warrant to confirm the current findings.
