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In dairy cattle, identifying polymorphisms that contribute to complex economical traits such as residual feed intake (RFI) is challenging and demands accurate genotyping. In this study, we compared imputed genotypes (n = 192 cows) to those obtained using the TaqMan and high-resolution melting (HRM) methods (n = 114 cows), for mutations in the FABP4...
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Context 1
... rare alleles, the joint VCF for these sires pointed to an SNP capable of encoding a conservative substitution of hydrophobic amino acids at the zinc-fingers-andhomeoboxes 2 gene (ZHX2 , Table 1), that co-segregates with the top BTA14 SNP marker. To investigate the possible effect of this SNP on RFI by imputing its genotypes in the cow test sample, we examined an additional 15 SNPs within an interval (~115 Kbp) of this gene locus (Table 4). ZHX2 locus showed segregation for most of the 16 examined SNPs in this bull sample (except for BTB-00553789, which showed no sequence variation among the 19 sires, Table 4). ...Context 2
... investigate the possible effect of this SNP on RFI by imputing its genotypes in the cow test sample, we examined an additional 15 SNPs within an interval (~115 Kbp) of this gene locus (Table 4). ZHX2 locus showed segregation for most of the 16 examined SNPs in this bull sample (except for BTB-00553789, which showed no sequence variation among the 19 sires, Table 4). Based on shared haplotypes between the test and the reference samples, alleles were imputed for all 16 SNPs of the combined population of 211 individuals. ...