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SNP characteristics including localization, rare allele frequencies in unrelated founders 

SNP characteristics including localization, rare allele frequencies in unrelated founders 

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Article
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The plasma lipid levels play crucial roles in the development of atherosclerotic diseases. We estimated the genetic variance of the lipid levels according to the contributions of the single nucleotide polymorphisms (SNPs) and haplotypes in 5 candidate genes.

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Conference Paper
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Abstract Text: An improved regional mapping method is proposed based on haplotype information with haplotype blocks being used as analysis regions. Genomic data were simulated using circa 300K SNPs. The simulated phenotypes’ heritability was 0.30 from which 0.05 was regional heritability. Twenty different regions of genome were selected to be tra...