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SCC in middle esophagus (mucosal invasion: carcinoma in situ; depressed type; 11 mm). (a) NBI endoscopy revealed demarcated area brownish in color with NBI image visualization quality rated as fair for delineating approximately one-half of lesion margin circumference as remaining portion of lesion margin appeared dim (white arrows). (b) AFI endoscopy clearly revealed demarcated area magenta in color with AFI image visualization quality rated as excellent for delineating entire lesion margin circumference.
Source publication
Aim. To compare narrowband imaging (NBI) and autofluorescence imaging (AFI) endoscopic visualization for identifying superficial esophageal squamous cell carcinoma (SCC). Methods. Twenty-four patients with superficial esophageal carcinomas diagnosed at previous hospitals were enrolled in this study. Lesions were initially detected using white-light...
Similar publications
This review provides information regarding the preoperative examinations, indications for endoscopic resection (ER), and curability assessment in subjects with superficial esophageal squamous cell carcinoma (SCC). Narrow-band imaging (NBI) is a more sensitive modality for detecting esophageal cancer than conventional observation, and esophageal obs...
Background and Goals
This study aimed to investigate the diagnostic accuracy of magnifying endoscopy with narrow band imaging (ME-NBI) and determine its value for invasion depth staging in esophageal squamous cell carcinoma.
Methods
We searched the PubMed, Embase, and Cochrane Library databases and found relevant studies published up to December 2...
Background:
We aimed to summarize the diagnostic accuracy of white light bronchoscopy (WLB) and advanced techniques for airway pre-cancerous lesions and early cancer, such as autofluorescence bronchoscopy (AFB), AFB combined with WLB (AFB + WLB) and narrow-band imaging (NBI) bronchoscopy.
Methods:
We searched for eligible studies in seven electr...
Background and study aim
Magnifying endoscopy enables the diagnosis of advanced neoplasia throughout the gastrointestinal tract. The unified magnifying endoscopic classification (UMEC) framework unifies optical diagnosis criteria in the esophagus, stomach, and colon, dividing lesions into three categories: non-neoplastic, intramucosal neoplasia, an...
Esophageal squamous papillomas are rare epithelial lesions typically discovered incidentally during EGD. Their prevalence is estimated to be less than 0.01% in the general population. We present three cases of esophageal squamous papillomas identified histologically. It may be possible to identify these lesions macroscopically. One study provided a...
Citations
... The reflection is captured by a charge-coupled device chip (CCD), and an image processor creates a composite pseudocolour image, which is displayed on a monitor, enabling NBI to enhance visualization of epithelial and vascular changes [17]. Using magnifying endoscopy with NBI increases the quality of vascular change visualization [18,19]. Every mucosal neoplasia development and growth is accompanied by neoangiogenesis, which can be visualized as specific changes in IPCL (Figs. 1A and 2A). ...
... According to data in the literature, both AFI and NBI are highly effective in this role. To date, only a few studies have compared the effectiveness of both methods for different organ structures, including the oesophagus, lungs and larynx [18,29,35]. ...
... Regarding the determination of the extent of the lesion, significantly better results were achieved using the AFI method. This is inconsistent with the results published by Japanese authors who tested both methods for oesophageal examination [18]. They concluded that NBI may be more effective than AFI for the visualization of oesophageal SCC. ...
Purpose
Early detection of mucosal neoplastic lesions is crucial for a patient’s prognosis. This has led to the development of effective optical endoscopic diagnostic methods such as narrow band imaging (NBI) and autofluorescence (AFI). Independent of each other, both of these methods were proven useful in the detection of mucosal neoplasias. There are limited reported data comparing both methods for oropharyngeal cancer diagnostics. The aim of the study was to compare NBI and AFI endoscopic visualization of signs in identifying tonsillar squamous cell carcinoma (SCC) and assessing its extent and to determine whether the score was related to the evaluator’s experience.
Methods
Patients with tonsillar SCC underwent endoscopic pharyngeal examination using NBI and AFI. Fiftyseven video sequences of examinations of lesions proven to be SCC were evaluated by three reviewers. The accuracy of determination of lesion extent and visualization of its endoscopic signs of malignancy were evaluated.
Results
Endoscopic visualization of tumour spread was significantly better using AFI than NBI (p = 0.0003). No significant difference was found between NBI and AFI in the visualization of endoscopic malignancy determining signs (p = 0.1405). No significant difference was found among the three reviewers in the visualization of tumour spread and for identifying malignancy-determining signs in NBI endoscopy or AFI endoscopy.
Conclusions
The results show that AFI obtained better results for assessing the extent of tonsillar cancers than NBI. Both methods were proven to be equal in the visualization of endoscopic malignancy-determining signs. Both are useful even for less experienced evaluators.
... 13 At present, narrow-band endoscopic imaging and endoscopic mucosal resection are widely used in the diagnosis of early gastrointestinal tumors, which greatly improves the diagnosis and treatment of early gastrointestinal tumors. 14 The application of narrow-band imaging technology in early diagnosis of digestive tract tumors can effectively enhance the contrast effect of uncolored mucosa, and under the assistance of special narrowband filter, the internal condition of digestive tract can be clearly observed and the slight changes in digestive tract mucosa can be displayed, which significantly improve the diagnostic accuracy. 15 In addition, in the treatment of digestive tract tumors, corresponding surgical treatment can rely on digestive endoscopy, which can not only reduce the surgical wounds of patients, but also will not cause significant damage to the surrounding organs and effectively shorten the operation time and hospitalization time. ...
Objective:
To explore the value of gastrointestinal endoscopy in the early diagnosis and treatment of gastrointestinal tumors and lay a foundation for the diagnosis and treatment of gastrointestinal tumors.
Methods:
One hundred and eight patients with gastrointestinal tumors who were admitted to our hospital from August 2016 to April 2018 were retrospectively analyzed and divided into observation group and control group according to different diagnostic methods, 54 cases in each group. The control group was treated with traditional endoscopy (white light imaging) and traditional surgery, while the observation group underwent narrow band imaging (NBI) based on endoscopic examination and endoscopic mucosal resection. The image quality scores (morphological image, gastric pit image and capillary image), diagnostic accuracy, surgery related clinical indicators (operation time, intraoperative bleeding volume, hospitalization days) and complications were observed and compared between the two groups.
Results:
The morphological image, gastric pit image and capillary image scores of the observation group were higher than those of the control group (P<0.05). The diagnostic accuracy rate of the observation group was 96.30%, which was significantly higher than 75.93% (P<0.05). The operation time and hospitalization days of the observation group were shorter than those of the control group, and the intraoperative bleeding volume of the observation group was less than that of the control group; the differences were statistically significant (P<0.05). The incidence of complications of the observation group was lower than that of the control group, and the difference was statistically significant (P<0.05).
Conclusion:
Gastrointestinal endoscopy can accurately identify the pathological changes of tumors in the early diagnosis and treatment of gastrointestinal tumors, improve the diagnostic accuracy rate, and guide the implementation of treatment measures to improve clinical indicators. Moreover the incidence of postoperative complications is low. It is worth clinical promotion.
... This method may identify lesions, including malignancies, by detecting differences in tissue natural fluorescence, thus revealing early carcinomas, not yet detectable by conventional WLE [34]. However, in a study comparing NBI and AFI, the former was found to be superior [35]. While this technique-combined with NBI and HRE, called tri-modal imaging-has been studied well in Barrett's esophagus and early EAC, further studies are required for its use in SCD and early cancer. ...
Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) comprise the majority of esophageal cancers, and they differ from each other in several aspects. While the incidence of EAC is increasing in the West, ESCC is still the predominant cancer type worldwide. Squamous dysplasia is considered to be a premalignant lesion to ESCC; however, the exact probability and timeline of malignant transformation are not known, hence the lack of guidelines for management of such lesions. ESCC carries a poor prognosis if not detected early, so there has been a trend towards early detection and treatment. Diagnostic modalities include endoscopic ultrasound, white light endoscopy, non-endoscopic methods such as biomarkers, etc. Early diagnosis can identify a subset of patients who could benefit from less invasive endoscopic eradication therapies. This review aims to discuss the different modalities for diagnosis and treatment of early esophageal squamous lesions, including the newer endoscopic therapies, and comparison of different techniques.
... The benefit of NBI in comparison with white light (WL) endoscopy and other endoscopic tools, such as autofluorescence for the detection of premalignant and malignant lesions, is well reported [10][11][12][13][14]. It can be demonstrated that the use of NBI increases the sensitivity from 80-90 to 97-100 % and specificity from 75 to 99 % [15,16] for the detection of recurrent respiratory papillomatosis and nasopharyngeal carcinoma. ...
No clinical standard procedure has yet been defined to quantify the vascular pattern of vocal folds. Subjective classification trials have shown a lot of promise. Narrow band imaging (NBI) as an endoscopic imaging tool is useful, because it shows the vascular structure clearer than white light endoscopy (WL) alone. Endoscopic images of 74 human vocal folds (NBI and WL) were semi-automatically evaluated after image processing with respect to pixels of vessels and mucosa by the software MeVisLab. The ratios of vessel/mucosa pixels were compared. Using NBI, more vocal fold vessels are visible compared with WL alone (p = 0.000). There may be a difference between the right and left vocal folds due to the handedness of the examiner (p = 0.033) without any interaction between the method (NBI/WL) and the side (right/left) (p = 0.467). MeVisLab is a suitable tool for the objective quantification of the vessel/mucosa ratio for NBI and WL endoscopic images. NBI is an appropriate endoscopic tool for examination of diseases of vocal folds with changes in the vascular pattern. There is evidence that the handedness of the examiner may have an influence on the quality of the examination between the right and left vocal folds.
Early diagnosis and early treatment of gastrointestinal tumors are helpful to improve the prognosis of patients. Endoscopy is the best method for the diagnosis of early gastrointestinal tumors, but some early flat tumors may be missed under conventional white-light endoscopy. In order to improve the accuracy of endoscopic diagnosis of gastrointestinal tumors, especially early flat tumors, endoscopic autofluorescence imaging (AFI) as a new technique has been widely used in clinics in recent years. This article reviews the progress of the clinical application of AFI in the diagnosis of various gastrointestinal tumors.
Since the esophagus is easily accessible with endoscopy, early diagnosis and curative treatment of esophageal cancer is possible. However, diagnosis is often delayed because symptoms are not specific during early stages of tumor development. The onset of dysphagia is associated with advanced disease, and fewer than 15% of patients survive for 5 years. Population screening by endoscopy is not cost effective, but a number of alternative imaging and cell analysis technologies are under investigation. The ideal screening test should be inexpensive, well tolerated, and applicable to primary care. Over the last 10 years, significant progress has been made in endoscopic diagnosis and treatment of dysplasia (squamous and Barrett’s), and early esophageal cancer using resection and ablation technologies supported by evidence from randomized controlled trials. We review the state-of-the-art technologies for early diagnosis and minimally invasive treatment, which together could reduce the burden of disease.
With the aim to reduce cancer mortality, early detection of neoplasia is one of the most challenging tasks in upper and lower of gastrointestinal endoscopy. Despite microscopic architectural and cellular differences between normal, premalignant and early malignant epithelia, standard endoscopy often fails to be sufficiently informative for the human eye, due to the lack of colour contrast in white-light mode. Autofluorescence imaging (AFI) is based on the property of short wavelengths to excite endogenous molecules in the gastrointestinal mucosa to emit fluorescence and exploits different fluorescent properties of neoplastic compared to normal tissue. Hence, AFI stands as a red-flag wide-field endoscopic technique for early cancer detection.
Early diagnosis and treatment can improve the outcomes of patients with gastrointestinal neoplasms. Although digestive endoscopy is considered as a best method to diagnose gastrointestinal neoplasms, some early stage, flat-type neoplasms may be overlooked by routine endoscopy. In recent years, endoscopic autofluorescence imaging (AFI) as a new technique, has been widely applied in clinical practice for enhancing the endoscopic diagnostic accuracy of gastrointestinal neoplasms, especially for early stage, flat-type neoplasms. This article reviewed the clinical application of AFI for diagnosis of gastrointestinal neoplasms. ©, 2014, Shanghai Institute of Digestive Diseases. All right reserved.
Objective:
Autofluorescence imaging (AFI) systems may allow better visualization of colorectal neoplasia than conventional methods. However, this is difficult to demonstrate objectively. Recently, a second-generation AFI system with a noise-reduction algorithm was developed. We aimed to objectively evaluate the visualization of colorectal neoplasia by using a second-generation AFI system and software to calculate the color-contrast index.
Material and methods:
We retrospectively reviewed 53 consecutive colorectal neoplasias examined using the second-generation AFI system. Color-contrast indices between the colorectal lesions and the surrounding normal mucosa in the WLI, AFI and NBI images were calculated. The WLI, AFI, NBI and CE images were also evaluated by endoscopists using questionnaire-based visualization scores.
Results:
The color-contrast index seen in the AFI images (33.74 ± 9.20) was significantly higher than that in either the WLI (11.14 ± 6.14) or NBI images (11.72 ± 7.12). There was no significant difference between the color-contrast indices of the WLI and NBI images. The mean AFI image visualization score (6.7 ± 1.8) was significantly higher than that of WLI (6.0 ± 1.7), and tended to be higher than that of the NBI images (6.1 ± 1.6) when assessed by less-experienced endoscopists.
Conclusions:
This study objectively demonstrates that compared to WLI and NBI, the second-generation AFI system enables superior visualization of colorectal neoplasms. The visualization scores were higher for the AFI images when evaluated by less-experienced endoscopists. These results indicate that the second-generation AFI system may aid less-experienced endoscopists in the detection of colorectal neoplasia.
