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SCAP: double layer of cells. The inner layer is composed of columnar cells, where decapitation secretion is observed, and the outer layer is formed by cuboidal cells. Stroma with infiltrate rich in inflammatory cells, mainly plasma cells. (Hematoxylin & eosin X40)
Source publication
Syringocystadenoma papilliferum and tubular apocrine adenoma are rare benign sweat gland tumors. Syringocystadenoma papilliferum occurs alone or in association with other tumors. Although it is rare, the association of tubular apocrine adenoma with syringocystadenoma papilliferum developing in a sebaceous nevus on the scalp is well documented. Howe...
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Clear cell hidradenoma (CCH), a rare yet benign finding, is a tumor that originates from sweat glands. It mainly presents as a slow-growing cystic nodule on the scalp or trunk. We report a case of a 60-year-old man who presented with an abdominal subcutaneous mass. This mass was excised and pathology confirmed the presence of CCH, with cytology neg...
Citations
... Paget's disease cells often exhibit nuclear pleomorphism and frequently test positive for HER2 and EMA [7]; (2) invasive ductal carcinoma, when NA presents a pseudo-in ltrative pattern, it may be confused with Invasive ductal carcinoma IDC , but NA has a double layer of epithelial and myoepithelial cells, while breast cancer lacks myoepithelium and shows marked cellular atypia, common mitotic gures, and tumor nest formation, with immunohistochemical markers P63,CK5/6 helping to differentiate; (3) syringomatous tumor, which feature ducts of teardrop, comma, and branching shapes, and exhibit in ltrative growth with desmoplastic stroma. These tumors may show perineural invasion but do not involve the epidermis; (4) SCAP-TAA, as NA can be associated with apocrine metaplasia, Our initial biopsy mistakenly identi ed the condition as SCAP-TAA, which presents as cystic invaginations of the infundibular epithelium projecting into the dermis, covered by a double cell layer; the innermost layer is composed of columnar cells with decapitation secretion, and the outermost layer is composed of cuboidal cells with papillary projections, with immunohistochemical positivity for carcinoembryonic antigen(CEA) and epithelial membrane antigen EMA helping to differentiate [14]. ...
Background：Nipple adenoma is a rare benign nipple tumor that is seldom seen in males and can be challenging to differentiate from Paget's disease.
Case report：We report the case of a boy with nipple adenoma who was initially misdiagnosed with Syringocystadenoma papilliferum combined with a tubular apocrine adenoma. Six months post-diagnosis, a nipple-areolar resection was conducted, followed by a purse-string suture technique to restore and reshape the nipple's appearance. Histopathological examination confirmed the diagnosis of nipple adenoma.
Conclusion：Nipple adenomas often prove difficult to alleviate without surgical intervention; surgical excision is deemed the gold standard for treatment. It is vital to establish a clear pathological diagnosis for nipple adenomas, as they are benign tumors, to prevent unnecessary overtreatment.
... 3,4 A rich and dense plasmacytic infiltrate is also present in the fibrovascular stroma. 1,4,9 Syringocystadenoma papilliferum is mainly a histopathological diagnosis, and the role of radiology has not been well-established. 6 In one of the rare reports on this topic, Kamakura et al have stated that magnetic resonance imaging may play a role in the diagnosis and differential diagnosis of syringocystadenoma papilliferum. ...
Out of all benign tumors of the ceruminous glands, syringocystadenoma papilliferum is the rarest and represents only 2% of cases. It is an extremely rare benign tumor that originates from modified apocrine sweat glands. The aim of this paper was to present, according to our findings, the 18th case of syringocystadenoma papilliferum in the external auditory canal, with a detailed review of its clinical, radiological and histomorphological characteristics. A 59-year-old man reported to our clinic due to a 5×5 mm papillomatous growth at the entrance to the right external auditory canal. Histopathology indicated, after an excisional biopsy, that it was a syringocystadenoma papilliferum. The resection lines were free of tumor tissue, and the patient has no signs of tumor recurrence. Although rare, it should be considered as a differential diagnosis of lesions in this region. Complete excision is mandatory in order to avoid recurrence and potential malignant alteration.
... SCAP was a benign skin adnexal tumor whose origin and pathogenesis are unknown. Some scholars believe that it originates from large and small sweat glands or pluripotent stem cells [4]. It was firstly reported by Petensen in 1982 (reference unavailable), and there are currently few reported clinical cases. ...
Background:
Syringocystadenoma papilliferum (SCAP) represents a rare, noncancerous adnexal tumor predominantly presenting at birth or in early childhood.
Case summary:
In this study, a 35-day-old girl was admitted to Kunming Children's Hospital in October 2019 due to a lesion in the right frontotemporal region since birth. The surface of the lesion was bright red, granular, and papillary and easily bled upon touch, with about 1.5 cm × 4 cm in size. A subcutaneous mass was felt at the base of the lesion, with a size of about 3 cm × 5 cm. Dermatoscopy showed that the skin lesion was lobular and crumby. The lesion center was reddish or white, while the edges were white or yellowish band-like. There were polymorphic vascular structures and white radial streaks in the lesion, with some vascular clusters scattered. Pathological examination showed papilloma-like hyperplasia of the epidermis, with the epidermis partly sinking into the dermis to form several cystic depressions. Combining clinical and histopathological features, the child was diagnosed with SCAP. Follow-up is ongoing, and surgical resection will be performed.
Conclusion:
This was a special clinical manifestation of SCAP, which complements the clinical manifestations of the disease and provides new insights for the diagnosis and differentiation of neonatal skin tumors.
Syringocystadenoma papilliferum (SCAP), tubular apocrine adenoma (TAA), and eccrine nevus are rare benign sweat gland tumors with varied clinical presentations but generally distinctive histomorphologic profiles. TAA and SCAP have been associated with other cutaneous hamartomas, most commonly with nevus sebaceus. Additionally, TAA and SCAP have uncommonly co‐occurred in the same lesion. In contrast to nevus sebaceus, eccrine nevus is considerably less common and is rarely associated with other benign adnexal lesions. Here we present an unusual case of a complex sweat gland hamartoma containing features of syringocystadenoma papilliferum, tubular apocrine adenoma, and eccrine nevus in a 7‐year‐old female. This article is protected by copyright. All rights reserved.
Résumé
But
Préciser les caractéristiques cliniques, histologiques, immunohistochimiques d’une grande série de cas d’hidradénomes papillifères et souligner les similitudes avec les tumeurs mammaires.
Méthodes
Nous avons effectué une étude anatomoclinique monocentrique rétrospective. Les cas d’hidradénomes papillifères du laboratoire de dermatopathologie de Strasbourg (1977–2017) ont été inclus et analysés en coloration hématoxyline-éosine et avec différents immunomarquages. Le diagnostic était retenu lorsqu’il existait des zones tubulaires et des zones papillaires, avec un revêtement constitué de cellules luminales cylindriques et de cellules périphériques myo-épithéliales.
Résultats
Nous avons inclus 32 cas concernant uniquement des femmes, d’âge moyen 49 ans. La localisation préférentielle était vulvaire (67 %) et péri-anale (25 %). La taille variait de 3 mm à 25 mm. Il s’agissait de tumeurs uniques habituellement non ulcérées, de couleur chair, pouvant mimer un kyste. Les lésions étaient localisées majoritairement dans le derme moyen. Nous avons identifié plusieurs variantes morphologiques à l’histologie. Trois HP avaient une architecture proche d’un adénome tubulaire apocrine, 3 d’un cystadénome apocrine ; 9 HP étaient connectés à l’épiderme, avec acanthose hyperplasique dans 3 cas et infiltrat inflammatoire dermique, se rapprochant d’un syringocystadénome papillifère. Seize HP ne comportaient pas d’atypies cytologiques ou architecturales. Des similitudes avec la pathologie tumorale mammaire se manifestaient par une hyperplasie des cellules luminales (6 cas), un taux de mitoses élevé (4 cas) et des atypies nucléaires (3 cas). Des glandes ano-génitales de type mammaire étaient trouvées à proximité de 10 HP. Les cellules myo-épithéliales exprimaient l’actine muscle lisse et p63, et les cellules luminales exprimaient CK7, CK8, EMA et de manière plus focale et inconstante Ber-EP4, CD117, PHLDA1 et les récepteurs aux androgènes.
Conclusion
Notre étude a mis en évidence une diversité d’architecture et de morphologie cellulaire, parfois au sein d’une même tumeur, identique à celle de la pathologie mammaire. Les caractéristiques immunohistochimiques des HP sont identiques à celles des glandes ano-génitales de type mammaire, ce qui justifie l’appellation d’« adénome des glandes ano-génitales de type mammaire ».
