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Results of the second bone marrow examination. (A) An aspirate smear showing increased number of blasts and dyserythropoiesis (arrow) (Wright staining, ×1,000). (B) An aspirate smear showing increased number of blasts and dysgranulopoiesis (arrow) (Wright staining, ×1,000).
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Human brucellosis is an important zoonotic disease and has a wide clinical spectrum. Nonspecific hematologic abnormalities related to brucellosis are frequently found, but pancytopenia is uncommon. Malignant diseases have been infrequently reported as a rare cause of pancytopenia in patients with brucellosis. We describe a patient with brucellosis...
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Brucellosis is a highly contagious and important zoonotic disease caused by different species of the genus Brucella, a small, facultative, gram negative, non-motile, non-spore forming, rod shaped (coccobacilli) bacteria. In goats and sheep, brucellosis is mainly caused by Brucella melitensis. Brucellosis may give rise to significant economic losses...
Citations
... It is caused by Brucella, a small, slow growing, intracellular Gram-negative coccobacillus that is transmitted to humans by direct contact with infected animals or intake of contaminat-ed raw animal products, such as unpasteurized milk [1,[4][5][6][7]. Brucellosis almost always causes fever, which may be associated with night sweats [5,8]. Common treatment includes doxycycline and aminoglycosides, although complicated cases, such as brucellosis combined with endocarditis, osteoarticulitis, or neurobrucellosis, may require stronger medicatinos administered for a longer duration [9][10][11]. ...
Brucellosis is a zoonotic infection that is usually transmitted from cattle to humans through ingestion of animal milk, direct contact with animal parts, or inhalation of aerosolized particles. In Korea, brucellosis seem to be transmitted through close contact with blood, fetus, urine, and placenta of domestic cow that has been infected by Brucella abortus, or inhalation of B. arbortus while examining or slaughtering cow. Brucella melitensis infection is rare in Korea and there have been no reported cases of B. melitensis originating from other countries until now. This report details a case of complicated brucellosis with infective spondylitis in a 48-year-old male construction worker recently returned from Iraq. Infection with B. melitensis was confirmed using 16s rRNA sequencing and omp31 gene analysis. The patient was successfully treated using a combination of rifampin, doxycycline, and streptomycin, in accordance with WHO guidelines. This is the first reported case of complicated brucellosis with infective spondylitis in Korea caused by B. melitensis originating from Iraq.
