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Results of MTT assay on (a) MCF7 cells, (b) HONE1 cells, (c) CNE2 cells, and (d) HSF98 cells upon treatment of the lectin for time intervals. Data represent mean ± SD (n=3). Data points marked with ∗ represent p<0.05.
Source publication
A lectin exhibiting antiproliferative activity on tumor cell lines but devoid of antifungal activity has been purified from
Phaseolus vulgaris
cv. Green Dragon no. 8 seeds. The lectin was a 60 kDa dimeric protein with two 30 kDa subunits. It was a glucosamine-specific lectin as implied from the inhibitory effect of glucosamine on hemagglutinating a...
Citations
... Hasil penelitian lainnya menyatakan bahwa buncis dapat diolah sebagai obat antidiabetes dikarenakan buncis kaya kandungan senyawa bioaktif yang mampu menghidrolisis enzim sehingga protein membentuk senyawa peptida bioaktif yang mengandung antioksidan yang yang tinggi sehingga usus tidak banyak menyerap glukosa dan merangsang sekresi insulin (de Souza Rocha et al., 2015;Maripa et al., 2019). Sayuran buncis dapat digunakan sebagai obat antikanker karena mengandung senyawa glucosamine (Chan et al., 2015). ...
Desa Meunasah Kulam terletak di Kabupaten Aceh Utara Provinsi Aceh dengan penghasilan utama masyarakatnya bersumber dari sektor pertanian yaitu bertani dan beternak. Di massa pandemi Covid-19 masyarakat diharuskan untuk melaksanakan kegiatan di rumah supaya dapat memutus mata rantai penyebaran Covid-19 akibatnya terjadi penurunan pendapatan di masyarakat. Solusi yang ditawarkan melalui kegiatan pengabdian kepada masyarakat ini adalah dengan melaksanakan pendampingan kegiatan usaha rumahan sehingga dapat meningkatkan penghasilkan keluarga. Usaha rumahan yang di dihasilkan yaitu produk crispy beans. Kegiatan dilaksanakan di rumah Geucik yang dihadiri oleh ibu – ibu rumah tangga. Tahapan kegiatan terdiri dari tahap persiapan, tahap pengolahan produk dan tahap pemasaran produk. Kesimpulan kegiatan pengabdian masyarakat ini adalah ibu – ibu menjadi lebih terampil dalam mengolah bahan makanan khususnya sayuran buncis menjadi produk yang lebih menarik dan lebih disukai masyarakat khusunya anak – anak sehingga dapat meningkatkan perekonomian keluarga terutama dimasa pandemi covid-19.
... µM), and 72 h (IC50 = 28.7 µM), preventing the cells from dividing and kept them at the G2/M phase. It also had an effect on nasopharyngeal carcinoma CNE2 cells, after 24 and 48 h treatment [93]. The EAPL showed antitumor activity against nasopharyngeal carcinoma (CNE-1, CNE-2, HNE-2) cell lines, breast cancer cells (MCF-7) e hepatocellular carcinoma (HepG2), inhibiting their proliferation in a dose dependent manner. ...
Lectins were discovered first in plants and later in other living things, and nowadays it is known that they are present in almost all many life forms. These proteins can bind to specific carbohydrates, which make them perform a number of biological activities and can be used as tools in the study of glycoconjugate structures present on the cell surface, being effective in medical research. Plant lectins, leguminosae lectins particularly, are among the most studied plant proteins. They are very versatile molecules, which show several interesting biological properties. Thus, the present paper reviewed the advances about the leguminosae lectins biological properties studies in the last ten years, taking into account their possible applications in the fields of Clinical Microbiology, Pharmacy and Cancerology through a search in the electronic databases, providing opportunity to exchange information about the theme. Leguminosae lectins can neutralize pathogenic organisms, be they viruses, prokaryotes and eukaryotes, in addition carcinogenic cells, besides decreasing oxidative stress, conditions which increases the possibility of alternative substances for the design of new drugs to be used in current therapeutic, expanding the possibilities of diseases cure. HIGHLIGHTS Leguminous lectins are proteins found in various parts of leguminous plants. Leguminous lectins are versatile in the carbohydrate binding specificity. Leguminous lectins have antimicrobial, antioxidant and antiproliferative features. Leguminous lectins are promising molecules for the design of new drugs. 2 De Souza Barbosa, P.P.; et al.
... µM), and 72 h (IC50 = 28.7 µM), preventing the cells from dividing and kept them at the G2/M phase. It also had an effect on nasopharyngeal carcinoma CNE2 cells, after 24 and 48 h treatment [93]. The EAPL showed antitumor activity against nasopharyngeal carcinoma (CNE-1, CNE-2, HNE-2) cell lines, breast cancer cells (MCF-7) e hepatocellular carcinoma (HepG2), inhibiting their proliferation in a dose dependent manner. ...
Abstract Lectins were discovered first in plants and later in other living things, and nowadays it is known that they are present in almost all many life forms. These proteins can bind to specific carbohydrates, which make them perform a number of biological activities and can be used as tools in the study of glycoconjugate structures present on the cell surface, being effective in medical research. Plant lectins, leguminosae lectins particularly, are among the most studied plant proteins. They are very versatile molecules, which show several interesting biological properties. Thus, the present paper reviewed the advances about the leguminosae lectins biological properties studies in the last ten years, taking into account their possible applications in the fields of Clinical Microbiology, Pharmacy and Cancerology through a search in the electronic databases, providing opportunity to exchange information about the theme. Leguminosae lectins can neutralize pathogenic organisms, be they viruses, prokaryotes and eukaryotes, in addition carcinogenic cells, besides decreasing oxidative stress, conditions which increases the possibility of alternative substances for the design of new drugs to be used in current therapeutic, expanding the possibilities of diseases cure.
... Beberapa penelitian yang membuktikan bahwa buah buncis dan buah pare terbukti dapat dijadikan sebagai obat antidiabetes yaitu senyawa bioaktif pada buncis menghidrolisis enzim sehingga protein akan membentuk peptida bioaktif dengan kapasitas antioksidan tinggi. Dengan cara ini akan mengurangi usus menyerap glukosa dan merangsang sekresi insulin (Thais et al, 2015), buncis juga mengandung glukosamin yang berfungsi sebagai antikanker (Chan, 2015). Isolat aktif yang berasal dari fraksi n-heksana ekstrak etanol buah pare (M. ...
This research was conducted to determine the quality of antidiabetic traditional medicines from beans and bitter melon after 6 months of storage. Beans and bitter melon contain bioactive compounds such as flavonoids, beta sitosterol, stigmasterol, alkaloids, saponins, and phenols which function as antidiabatic. However, environmental factors such as production processes, and environmental temperatures affect the storage process. So we need to test the quality of antidiabetic drugs after 6 months of storage. The tests are pH test, total plate number test, mold and yeast number test. Based on the test the following results are obtained. The pH obtained was 4.75, the plate number was 0.002 colonies / g, mold number and yeast 0.01 x103 colonies / g. Based on these results, the quality of antidiabetic traditional medicines from beans and bitter was kept in quality after 6 months of storageKeywords: Quality of storage, traditional medicine, beans, bitter melon
