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Immunomodulators can alter immune system and work specifically and non-specific. Traditionally Stachytarpetha jamaicensis herbs is used to modulate immune system. This study aims to determine the humoral and cellular immune system activity of water extract of S. jamaicensis herb through hemagglutination antibody titer test and delayed type hypersen...
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... of simplicia are very important to ensure the quality and indicate that the it has met the applicable requirements. The result of characterization of the simplicia can be seen in Table 1. The result of phytochemical screening of secondary metabolites from dried herbs and extract can be seen in Table 2. Specific immunomodulatory effect of water extract of S. jamaicensis was conducted with HA titre and delayed hypersensitivity test. ...Citations
... The biological activity is produced by the content of secondary metabolites such as alkaloids, flavonoids, phenols, steroids, and terpenoids [6]. The immunomodulatory effect of S. jamaicensis can be used for the treatment of autoimmune systemic lupus erythematosus [7,8], so this research is conducted to evaluate IOP Publishing doi:10.1088/1755-1315/1104/1/012008 2 the effect of extract of S. jamaicensis on animal models of psoriasis by measuring the hematological profile and ratio of organ to body weigt that play a role in psoriasis immune system. ...
Psoriasis is an autoimmune disease that occurs in the skin. An example of a drug that can induce psoriasis is imiquimod. This study aims to determine the effect of water extract of Stachytarpheta jamaicensis L. Vahl. leaves on haematological profile, spleen organ index and spleen histology in male Balb/c mice induced imiquimod. The extract was made by boiling water. The animals divided into 6 groups: normal, control, methotrexate 0.2 mg/kg BW, the extract at doses of 25, 50 and 100 mg/kg BW. Measurement of the haematological profile was carried out in the end of the srudy and the parameters were white blood cells, lymphocytes, mid-sized cells (MID), granulocytes, red blood cells, haemoglobin, haematocrit and platelets. The results showed that the extract at all doses can increase white blood cells including lymphocytes, MID, granulocytes, red blood cells, haemoglobin, haematocrit and platelets compared to control group (p<0.05). The result also showed that the extract at all dose can prevent enlargement of the spleen and reduce the level of lymphocyte infiltration in the spleen. It can be concluded that the water extract of S.jamaicensis leaves affects the haematological profile and spleen organ on animal induced imiquimod.
... 11 Efek imunomodulator tersebut dapat bekerja secara spesifik dan non spesifik dan aktivitas ini terdapat pada tanaman pecut kuda yang dapat mempengaruhi sistem imun humoral dan selular. 17 Tanaman pecut kuda juga diketahui memiliki aktivitas sebagai antiinflamasi dengan efek samping yang lebih kecil jika dibandingkan penggunaan obat antiinflamasi nonsteroid. Aktivitas ini bekerja terhadap model hewan dengan peradangan akut dan kronis yang memungkinkan terjadinya penghambatan pada siklooksigenase. ...
Psoriasis is an autoimmune disease that is characterized by the appearance of lesions on the skin. The current treatment aims to control the symptoms. The efficacy of Stachytarpheta jamaicensis (L.) Vahl’s for autoimmune rheumatoid arthritis and systemic lupus erythematosus has been tested in animal models. The aim of this research was to evaluate the effect of the water extract of S. jamaicensis leaves on psoriasis model animal (male Balb/c mice) induced topically by imiquimod. The water extract of S. jamaicensis leaves is made by boiling. The animal was divided into groups: normal, control, methotrexate 0.2 mg/kgBW, the extract (doses 25, 50 and 100 mg/kgBW). The measured parameters were the Psoriasis Area and Severity Index (PASI) score and skin histopathology. The results showed that all doses of the extract could reduce the PASI score when compared to the control group. Histological results showed that there was a decrease in keratin growth in test animals that were given the extract. Extracts at doses of 25 and 50 mg/kgBW can reduce the thickening of keratin in the epidermis of the back and ears. It can be concluded that the water extract of S. jamaicensis leaf has the most effective activity to prevent psoriasis recurrence in the dose range of 25 and 50 mg/kgBW.Keywords: Psoriasis, Stachytarpheta jamaicensis leaf water extract, PASI, keratin, imiquimod
... On the 11 th day, apart from the primary antibody examination, reinduction (second injection) was also carried out with 2% SRBC (0.1 mL/10 g bw) to induce the formation of secondary antibody (IgG). Secondary antibodies were determined on the 16 th day during the administration of the test extract (5 th day after the second injection) with the determination of secondary antibody titer as carried out in the determination of the primary antibody (Faradilla and Iwo, 2014;Vikasari, et al., 2021). ...
Immunostimulants are compounds that can stimulate an immune response by increasing the activity of non-specific and specific components of the immune system (humoral and cellular) against certain infections and diseases. The liverwort plant species Marchantia paleacea Bertol. has long been used as a source of nutrition and empirical medicine. However, scientifically there is still not much research data on immunomodulators in these plants. This study aims to determine the activity of immunomodulators in the ethanol extract of the herb Marchantia paleacea Bertol. in male mice of BALB/c strain. Bioactive compounds from this plant were extracted by maceration method using 96% ethanol. Extract characterization and phytochemical screening were determined according to WHO guidelines and standard procedures from previous studies. The immunomodulatory activity of the extract was tested by carbon clearance method and lymphoid organ index (non-specific responses), primary and secondary antibody titer tests (humoral specific responses), IL-2 cytokine levels and IFN-ɣ from serum secondary antibodies and delayed-type hypersensitivity reaction/DTH (cellular specific response). The results of qualitative phytochemical screening contained flavonoid compounds, saponins, phenolics, tannins and steroids/triterpenoids. The results of the non-specific immune response immunomodulator test showed that the dose of 52 mg/kg bw had the largest phagocytic index of 1.52 which included strong immunostimulation (K > 1.5) and the organ spleen index of 0.55 ± 0.11 which increased significantly compared to the control (p<0.05). The data on the acquisition of specific immune responses in the primary and secondary antibody titer test in the three test extracts resulted in increased titer levels compared to the control and at a dose of 52 mg/kg bw could significantly increase the levels of IL-2 cytokines in the control group (p<0,05). Meanwhile, in DTH test, doses of 13 and 26 mg/kg bw could significantly increase the thickness of the soles of mice compared to controls (p<0.05).
... The present findings agree with the previous studies on healthy rats administered with methanolic leaf extract of Moringa oleifera, [33] and the concoction of Coriandrum sativum and Coscinium fenestratum [38], and on mice using an extract of zapoteca portoricensis [34] which showed a significantly higher mean haemagglutinating antibody titer to sheep red blood cells. The current results are in disagreement with a previous study [39] in healthy mice administered with the aqueous extract of Stachytarpetha jamaicensis, which resulted in significantly higher haemagglutinating antibody titer compared with the control group. The effects of the aqueous LP extract doses on the DTH reaction induced by the GRBCs were used to evaluate the adaptive immune response. ...
... The present findings agree with the previous studies using the methanolic leaf extract of Moringa oleifera on rats [33], the aqueous methanolic LP extract on rats [15], and the extract of zapoteca portoricensis in mice [34] that showed a higher mean percentage of footpad puffiness compared with the respective controls. On the other hand, the current results are in disagreement with a previous study [39] in healthy mice administered with water extract of Stachytarpetha jamaicensis, which showed a lower mean hind footpad thickness compared to the control group. Both the LD and HD of the aqueous LP extracts led to lower mean BW and feed and water intakes. ...
In this study, a novel multifunctional intelligent/active packaging material fabricated by immobilizing Stachytarpheta jamaicensis extracted (SJE) anthocyanins in a polymer matrix consisting of chitosan (CS) and polyvinyl alcohol (PVA) is described. The addition of SJE enhanced the tensile strength, barrier, and antioxidant activity of the films, and by increasing the SJE content, the tensile strength of the film reached 38.79 ± 3.52%, and antioxidant activity was found to be 81.72 ± 2.73%. The minimum oxygen permeability was 3.185 ± 0.532 × 10⁻⁶ (cc m⁻¹ 24 h atm), and the minimum water vapor permeability was 18.39 ± 0.18 g m⁻¹ h⁻¹. The UV-vis light transmittance and elongation at break were reduced when different contents of SJE were incorporated into the CS/PVA (CP) matrix. The smooth SEM images revealed that the miscibility and compatibility of the CP matrix with SJE anthocyanins were tolerable. The color of the film changed from pink to dark yellow when pH increased from 1 to 13. TGA profile indicated that the addition of SJE to CP significantly enhanced the thermal stability of the film. The prepared composite film changed color from pink to dark yellow when the estimated volatile base nitrogen content in the meat was 21.71 ± 0.59 mg/100 g. Hence, the prepared film with SJE can be used for the chicken meat packaging in real-time freshness monitoring at room temperature.
