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Helianthus annuus seeds contain various chemical components and evaluate different biological activities. The present study was carried out to investigate the central nervous system (CNS) activity of methanolic extract of Helianthus annuus seeds in mice model. General behaviour, antidepressant activity and anxiolytic activity was observed. The resu...
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... increased the number of entries compared to control. The number of entries into the closed arms was reduced by H. annuus at doses of 100 and 200 mg/kg[83][84]. ...
Insomnia and anxiety are worldwide medical problems. Plant extracts possessed sedative and anxiolytic effect via different mechanisms included interactions with Na+ channels, γ-aminobutyric acid type A receptors, N-methyl-D-aspartate receptors and chatecholamines. In the current review, Web Science, PubMed, Scopus and Science Direct, were searched to investigate the plants with sedative and anxiolytic effects.
... The anti-obesity activity of the methanolic extract of Helianthus annuus L. seeds was studied in mice model. [29]. Extracted oil from dehulled seeds (chlorogenic acid, present in hulls, interferes with lipid metabolism) reduced serum and hepatic cholesterol in healthy women. ...
Gul-e-Aftabparst (Helianthus annuus) is used as food and medicine worldwide. It is cultivated basically for its seeds, which give the world's second most important source of edible oil. It is a source of various chemical constituents which are used for the treatment of many fatal or life threatening diseases. Phytochemical analysis showed the presence of carbohydrates, phenolics, flavanoids, tannins, alkaloids, saponins, phytosterols, steroids, triterpenoids and fixed oils in the plant. In Unani System of Medicine its flowers are used medicinally, especially for brain and cardiac disorders. It possessed many pharmacological effects include anti-inflammatory, analgesic , anti-ulcer, central nervous system effects, hepatoprotective, and cardio-protective effects. This review highlights the chemical constituents and pharmacological effects of Helianthus annuus and its medicinal uses in the light of Unani Medicine.
... H. annuus 200mg/kg, 78±1.3) as compared with Imipamine (60mg/kg, 30.2±0.64) and control (190.8±0.75) [77]. ...
The recent studies showed that many plants affected the central nervous system and exerted many pharmacological effects including sedative, anticonvulsant, antidepressant, antipsychotic, anxiolytic, anti-Parkinson, memory-enhancing, locomotor and neuroprotective effects. The current review discuss the central nervous effects of the medicinal plants with special focus on their mode of action.
The Asteraceae (formerly Compositae) family contains approximately 1600 genera, many of which are known for their phytochemistry and pharmacological properties. Helianthus annuus is one of the most important plants in this family, known for producing oil and playing an important role in the economies of countries. This plant’s traditional uses date back more than 3000 years. The plants are ethnomedicinally significant and contain a variety of alkaloids, terpenoids, carbohydrates, fixed oils, steroids, amino acids, and other compounds. An important point to emphasize in this book chapter is that plants are highly adaptable to various environmental conditions, making them easier to cultivate and yielding higher yields. There is a substantial literature on the plant, but as research-based knowledge grows, it must be updated, so we will attempt to update this plant’s information in terms of its traditional uses, phytochemistry, and pharmacology properties; the pharmacological properties of H. annuus were investigated using a variety of sources, including medicinal plant databases, ethnobotanical and ethnopharmacological books, and peer-reviewed papers. This book chapter delves deeply into the chemical, nutritional, and pharmacological properties of H. annuus.Keywords
Helianthus annuus
SunflowerAsteraceaeFatty acidsPhenolic acids
The literary review is devoted to one-year-old sunflower (Helianthus annuus L.) - an annual herbaceous plant of the genus Sunflower (Helianthus L.), widely cultivated in the USA, Argentina, Turkey, Romania, the Russian Federation, mainly with the aim of obtaining oil from seeds. Russia produces up to 20.3% of one-year-old sunflower, which is one of the country's main food and technical crops. It accounts for over 80% of the sown areas of oilseeds, which are concentrated mainly in the Altai Territory, the Volga Region, the North Caucasus and the Central Black Earth Region. The review summarizes the information of the scientific literature on the chemical composition, biological activity of biologically active substances contained in different parts of one-year sunflower (Helianthus annuus L.). The data presented in the review show a wide range of pharmacological effects of the plant Helianthus annuus L., including anti-inflammatory, analgesic, antibacterial, antiplasmodium, anti-ulcer, antihistamine, antidiarrheic, hypolipidemic, litholytic, nephrolytic, anxiolytic, antioxidant, anticancerogenic, A wide range of pharmacological activity is due to the rich chemical composition of roots, flowers, leaves of Helianthus annuus L., which are currently used mainly in folk medicine and are cheap, available raw materials, which are the waste of processing this actively cultivated agricultural crop in the Russian Federation, which provides prospects for developing quality standards of various parts of the plant Helianthus annuus L. and medicines based on them for implementation in the medical and pharmaceutical practice of our country.
The operation of the central nervous system (CNS) has been a mystery until recently when its structures are being linked to activity and/or pathologies. The drugs that influence the CNS were seen as spiritual manipulators, and often times they were used to invite the spirit into the human body. Researches have proven that these myths are unfounded and have provided explanations for the observed effect of the agents on the brain and human behavior. Most of the agents used to influence the brain in prescience ages were derived from plants. These actions of plant-related substances were termed as mystical. Science has unraveled the causes of the actions of plants on the CNS. The substances in plants that influence the brain are the biomolecules it contained. This chapter examines these biomolecules and their effects and mechanism of action. The biomolecules could produce stimulant, depressive, antidepressant, cognitive, toxic, and dependence effect on the brain. Substances like caffeine, cocaine, tobacco, ergot, opioids, etc., have been well studied to obtain an explanation for their effects on the brain and behavior. This review also revealed that biomolecules that influence the CNS does so by: acting as an agonist or antagonist at receptor sites, releasing neurotransmitters, inhibiting enzymes that are involved in neurotransmitter physiology, altering intracellular enzyme or protein levels, altering ion level in the brain, interacting with gamma aminobutyric acid receptors at different sites, or acting as precursor/false precursor for the synthesis of neurotransmitters. These effects could be beneficial or harmful to the human body. Some may result in the amelioration of disease or cure of CNS disease conditions. The beneficial effects of herbal biomolecules are indeed enormous and have contributed to the advancement of CNS science and the quantity of life of human race.
Medicinal plants can exert antidepressant activity by many mechanisms included neutralization of various stress mediators (regulate the activity of the hypothalamic-pituitary-adrenal axis and reduce CRF, and ACTH and corticosterone) [5], interaction with serotonergic systems (5-HT3, 5HT2A, 5-HT1A), noradrenergic (α1 and α2 receptors) and dopaminergic (D1 and D2) receptors [6],restoring monoamine transmitters and their receptors to normal limits in certain regions of the cortex, in addition to reducing of oxidative stress and amelioration of inflammatory mediators. The current review discussed the antidepressant activity of medicinal plants, with emphasis on their mechanisms of action.
Helianthus annuus was used as food and medicine worldwide. It was cultivated basically for its seeds, which give the world's second most important source of edible oil. Phytochemical analysis showed that Helianthus annuus contained carbohydrates, phenolics, flavanoids, tannins, alkaloids, saponins, phytosterols, steroids, triterpenoids and fixed oils. It possesed many pharmacological effects included antiinflammatory, analgesic, antimicrobial, anti-plasmodial, antidiabetic, anti-ulcer, antidiarrheal, antihistaminic, reproductive, anticancer, antioxidant, anti-obesity, central nervous system effects and hepato-, nephro-and cardio-protective effects. This review highlighted the chemical constituents and pharmacological effects of Helianthus annuus.
