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Representative images of lesion preparations with the (A) balloon-and (B) ablation-based techniques. (A-1) Angiography revealed stenosis with severe calcification (arrows in A-1') in the mid left anterior descending artery (LAD). The boxed area in A-1 is shown magnified in A-1' without contrast. (A-2) Pre-percutaneous coronary intervention (PCI) optical coherence tomography (OCT) cross-sectional image showing severe near-circumferential calcification in the target lesion. (A-3) After lesion preparation with a modified balloon (A-3'), retrograde Type C coronary dissection (arrows) with flow limitation occurred, originating from the balloon dilatation site to the proximal LAD. (A-4) Post-lesion preparation OCT cross-sectional image detected a large coronary dissection (double-headed arrow) involving the media, and the calcium plaque remained unscathed. (A-5) Coronary flow was restored with 2 drug-eluting stents sealing the entire dissected segment. (A-6) Post-PCI OCT cross-sectional image showing asymmetrical stent expansion in the direction opposite to the calcium plaque. (B-1) Angiography showed stenosis with severe calcification (arrows in B-1') in the mid LAD. (B-2) Pre-lesion preparation OCT cross-sectional image showing severe near-circumferential calcification in the target lesion. The boxed area in B-1 is shown magnified in B-1' without contrast. (B-3) Rotational atherectomy (RA) with a 2.0-mm burr was performed, followed by modified balloon dilatation (B-3'). (B-4) Post-lesion preparation OCT cross-sectional image showing a calcified plaque with a smooth concave surface ablated by RA (arrowheads). (B-5) Treatment of the target lesion was finished with a drug-coated balloon, and the lesion was opened wide without severe dissection. (B-6) Post-PCI OCT crosssectional image showing multiple calcium fractures (arrows); the maximum thickness of the calcium fracture was 1,000 μm.

Representative images of lesion preparations with the (A) balloon-and (B) ablation-based techniques. (A-1) Angiography revealed stenosis with severe calcification (arrows in A-1') in the mid left anterior descending artery (LAD). The boxed area in A-1 is shown magnified in A-1' without contrast. (A-2) Pre-percutaneous coronary intervention (PCI) optical coherence tomography (OCT) cross-sectional image showing severe near-circumferential calcification in the target lesion. (A-3) After lesion preparation with a modified balloon (A-3'), retrograde Type C coronary dissection (arrows) with flow limitation occurred, originating from the balloon dilatation site to the proximal LAD. (A-4) Post-lesion preparation OCT cross-sectional image detected a large coronary dissection (double-headed arrow) involving the media, and the calcium plaque remained unscathed. (A-5) Coronary flow was restored with 2 drug-eluting stents sealing the entire dissected segment. (A-6) Post-PCI OCT cross-sectional image showing asymmetrical stent expansion in the direction opposite to the calcium plaque. (B-1) Angiography showed stenosis with severe calcification (arrows in B-1') in the mid LAD. (B-2) Pre-lesion preparation OCT cross-sectional image showing severe near-circumferential calcification in the target lesion. The boxed area in B-1 is shown magnified in B-1' without contrast. (B-3) Rotational atherectomy (RA) with a 2.0-mm burr was performed, followed by modified balloon dilatation (B-3'). (B-4) Post-lesion preparation OCT cross-sectional image showing a calcified plaque with a smooth concave surface ablated by RA (arrowheads). (B-5) Treatment of the target lesion was finished with a drug-coated balloon, and the lesion was opened wide without severe dissection. (B-6) Post-PCI OCT crosssectional image showing multiple calcium fractures (arrows); the maximum thickness of the calcium fracture was 1,000 μm.

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Background: Percutaneous coronary intervention (PCI) of heavily calcified lesions remains challenging. This study examined whether calcified lesion preparation is better with an ablation-based than balloon-based technique. Methods and Results: Results of lesion preparations with and without atherectomy devices were compared in 121 patients undergoi...

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Context 1
... Preparation by Atherectomy technique in 62 (balloon group) and with the ablationbased technique in 59 (atherectomy group). Representative images of lesion preparations in the balloon and atherectomy groups are shown in Figure 1. Patient and angiographic lesion characteristics are presented in Table 1. ...
Context 2
... Preparation by Atherectomy technique in 62 (balloon group) and with the ablationbased technique in 59 (atherectomy group). Representative images of lesion preparations in the balloon and atherectomy groups are shown in Figure 1. Patient and angiographic lesion characteristics are presented in Table 1. ...

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Background: Plaque characteristics associated with effective intravascular lithotripsy (IVL) treatment of calcification have not been investigated. This study identified calcified plaque characteristics that favor the use of IVL. Methods and Results: Optical coherence tomography (OCT) was performed in 16 calcified lesions in 16 patients treated with IVL and coronary stenting. Cross-sectional OCT images in 262 segments matched across pre-IVL, post-IVL, and post-stenting time points were analyzed. After IVL, 66 (25%) segments had calcium fracture. In multivariable analysis, calcium arc (odds ratio [OR] 1.22; 95% confidence interval [CI] 1.13–1.32; P<0.0001), superficial calcification (OR 6.98; 95% CI 0.07–55.57; P=0.0182), minimum calcium thickness (OR 0.66; 95% CI 0.51–0.86; P=0.0013), and nodular calcification (OR 0.24; 95% CI 0.08–0.70; P=0.0056) were associated with calcium fracture. After stenting, stent area was larger for segments with fracture (8.0 [6.9–10.6] vs. 7.1 [5.2–8.9] mm²; P=0.004). Conclusions: Post-IVL calcium fracture is more likely in calcified lesions with lower thickness, a larger calcium arc, superficial calcification, and non-nodular calcification, leading to a larger stent area.