Figure 1 - uploaded by Catherine Charreyre
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Représentation schématique de la préparation d'un vaccin sous-unitaire multivalent nanoparticulaire en échafaudage biologique. Un système d'expression est utilisé pour générer des nanoparticules (NP) porteuses de SpyCatcher, qui s'auto-assemblent spontanément. Les NP sont mises au contact d'antigènes A et B porteurs de SpyTag, et les deux molécules complémentaires SpyCatcher et SpyTag forment rapidement des liaisons iso-peptidiques très solides. Par simple mélange, un vaccin multivalent est alors obtenu, avec des NP recouvertes d'échafaudages biologiques stables porteurs des antigènes A et B.
Source publication
New strategies for innovative vaccination and their applications in veterinary medecine.
For the last 100 years, vaccination has had a tremendous positive impact on the health of humans and animals. Looking at the recent advances in our understanding of immunological mechanisms, and taking into account the possibility to combine several different s...
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